Trace elements in freshwater killifish, Aphanius stoliczkanus, from Oman: a food safety issue

Toxicology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102023 - 102023

Published: April 1, 2025

Freshwater killifish, Aphanius stoliczkanus, were collected from industrial and non-industrial areas in Oman to assess trace element levels muscle liver tissues estimate potential human health risks using the Estimated Daily Intake (EDI) Target Hazard Quotient (THQ). Samples obtained Al Amarart, Khawd, Surur analyzed Atomic Absorption Spectroscopy. Fish Amarart exhibited significantly higher concentrations of toxic elements, particularly arsenic (As), cadmium (Cd), lead (Pb), suggesting a strong influence activities. In contrast, fish Khawd lower, reflecting reduced anthropogenic inputs. almost all sites, most metals accumulated at than muscle, indicating increased bioavailability for essential elements or detoxifying function metals. Despite variation contamination levels, THQ values remained below threshold concern (THQ < 1), that individual exposure through consumption does not pose immediate risks. Similarly, calculated cancer risk (CR) As was within acceptable limits sites. However, while direct A. stoliczkanus appears low, cumulative effects multiple dietary environmental sources should be overlooked. Bioaccumulation trophic transfer water other food may long-term concerns. Overall, these findings highlight as valuable bioindicator regions. Continued monitoring stricter pollution control measures are recommended mitigate ensure safety. Further studies explore temporal trends additional toxicity biomarkers provide more comprehensive understanding ecological

Language: Английский

Chemical Pollutant Exposure in Neurodevelopmental Disorders: Integrating Toxicogenomic and Transcriptomic Evidence to Elucidate Shared Biological Mechanisms and Developmental Signatures

Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 282 - 282

Published: April 8, 2025

Rapid industrialization has introduced a range of chemicals into the environment, posing significant risks to fetal and child brain development. Using Comparative Toxicogenomics Database (CTD), we constructed chemical exposome frameworks for seven neurodevelopmental disorders (NDDs) identified pollutants epidemiological concern, including air (n = 8), toxic elements 14), pesticides related compounds 18), synthetic organic 16), solvents 5). Gene set enrichment analysis validated revealed toxicogenomic associations between these NDDs, autism spectrum disorder (ASD) (12 pollutants, proportional reporting ratio (PRR) 3.56–7.21) intellectual disability (ID) (9 PRR 3.13–5.59). Functional annotation pollutant-specific gene sets highlighted shared biological processes, such as metabolic processes (e.g., xenobiotic process, catabolic cytochrome P450 pathway) ASD cognitive cognition, social behavior, synapse assembly) ID (Bonferroni-corrected p-values < 0.05). Time trajectory developmental transcriptomic data from BrainSpan database (275 genes) (93 three distinct expression patterns chemical-pollutant-associated genes—higher prenatal, postnatal, perinatal expression—indicating common divergent underlying mechanisms across critical windows pollutant exposure.

Language: Английский