Metformin attenuated sepsis-related liver injury by modulating gut microbiota DOI Creative Commons

Huoyan Liang,

Heng Song, Xiaojuan Zhang

et al.

Emerging Microbes & Infections, Journal Year: 2022, Volume and Issue: 11(1), P. 815 - 828

Published: Feb. 22, 2022

Increased evidence shows that gut microbiota acts as the primary regulator of liver; however, its role in sepsis-related liver injury (SLI) elderly is unclear. This study assessed whether metformin could attenuate SLI by modulating septic-aged rats. Cecal ligation and puncture (CLP) was used to induce aged Fecal transplantation (FMT) validate roles these pathologies. The composition analysed 16S rRNA sequencing. Moreover, colon tissues were histopathology, immunofluorescence, immunohistochemistry, reverse transcription polymerase chain reaction (RT-PCR). Metformin improved damage, barrier dysfunction sepsis-induced inflammation damage under microbiota. Importantly, FMT assay showed rats gavaged with faeces from metformin-treated displayed less severe dysfunctions than those among sham-operated, CLP-operated different. In particular, proportion Klebsiella Escherichia_Shigella higher sham-operated rats; while increase Bifidobacterium, Muribaculaceae, Parabacteroides_distasonis Alloprevitella Additionally, correlated positively inflammatory factors liver. Our findings suggest may improve regulating alleviating rats, which be an effective therapy for SLI.

Language: Английский

Multidimensional Impact of Mediterranean Diet on IBD Patients DOI Creative Commons
Fabio Chicco, Salvatore Magrì, Arianna Cingolani

et al.

Inflammatory Bowel Diseases, Journal Year: 2020, Volume and Issue: 27(1), P. 1 - 9

Published: May 22, 2020

Abstract Background & Aims Malnutrition with the accumulation of fat tissue and nonalcoholic fatty liver disease (NAFLD) are conditions associated inflammatory bowel (IBD). Visceral NAFLD-related dysfunction can both worsen intestinal inflammation. Because Mediterranean diet (Md) has been shown to ameliorate obesity NAFLD, aim this study was analyze impact Md on nutritional state, steatosis, clinical activity, quality life (QoL) in IBD patients. Methods Patients IBD, Crohn’s (CD) ulcerative colitis (UC), followed for 6 months. Their body mass index (BMI), composition, steatosis function, serum lipid profile, biomarkers (C-reactive protein fecal calprotectin) were collected at baseline (T0) compared those obtained after months (T180) evaluate Md. Results One hundred forty-two patients, 84 UC 58 CD, At T180, diet-adherent CD improved BMI (UC −0.42, P = 0.002; −0.48, 0.032) waist circumference −1.25 cm, 0.037; −1.37 0.041). Additionally, number patients affected by any grade significantly reduced groups T0 31 [36.9%] vs T180 18 [21.4%], 0.0016; 27 [46.6%] [31.0%], < 0.001) dietary intervention. Finally, diet, fewer stable therapy had active 14 59 [23.7%] 4 [6.8%], 0.004; 9 51 [17.6%] 2 [3.0%], 0.011) elevated biomarkers. QoL but neither profile nor function modified diet. Conclusions A significant reduction malnutrition-related parameters observed short-term intervention based adoption Md, a spontaneous improvement activity markers.

Language: Английский

Citations

199
Gut Microbiota: An Important Player in Type 2 Diabetes Mellitus DOI Creative Commons
Zheng Zhou, Bao Sun, Dongsheng Yu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Feb. 15, 2022

Type 2 diabetes mellitus (T2DM) is one of the common metabolic diseases in world. Due to rise morbidity and mortality, it has become a global health problem. To date, T2DM still cannot be cured, its intervention measures mainly focus on glucose control as well prevention treatment related complications. Interestingly, gut microbiota plays an important role development diseases, especially T2DM. In this review, we introduce characteristics population, animal models, diabetic addition, describe molecular mechanisms linking host T2DM, including molecules that induce dysbiosis, immune inflammatory responses, microbial metabolites involved pathogenesis. These findings suggest can treat complications by remodeling through interventions such drugs, probiotics, prebiotics, fecal transplantation (FMT) diets.

Language: Английский

Citations

195
Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment DOI
Josep M. Llovet, Catherine E. Willoughby, Amit G. Singal

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 20(8), P. 487 - 503

Published: March 17, 2023

Language: Английский

Citations

195
Identification of a choroid plexus vascular barrier closing during intestinal inflammation DOI
Sara Carloni, Alice Bertocchi, Sara Mancinelli

et al.

Science, Journal Year: 2021, Volume and Issue: 374(6566), P. 439 - 448

Published: Oct. 22, 2021

Up to 40% of patients with inflammatory bowel disease present psychosocial disturbances. We previously identified a gut vascular barrier that controls the dissemination bacteria from intestine liver. Here, we describe in brain choroid plexus (PVB) is modulated response intestinal inflammation through bacteria-derived lipopolysaccharide. The induces PVB closure after opening by up-regulation wingless-type, catenin-beta 1 (Wnt/β-catenin) signaling pathway, rendering it inaccessible large molecules. In model genetically driven endothelial cells, observed deficit short-term memory and anxiety-like behavior, suggesting may correlate mental deficits. Inflammatory disease–related symptoms thus be consequence deregulated gut–brain axis.

Language: Английский

Citations

191
Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease DOI Open Access
Francesco Violi, Vittoria Cammisotto,

Simona Bartimoccia

et al.

Nature Reviews Cardiology, Journal Year: 2022, Volume and Issue: 20(1), P. 24 - 37

Published: July 15, 2022

Language: Английский

Citations

191
Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity? DOI Creative Commons
Judith Aron‐Wisnewsky, Moritz V. Warmbrunn, Max Nieuwdorp

et al.

Gastroenterology, Journal Year: 2020, Volume and Issue: 158(7), P. 1881 - 1898

Published: Feb. 8, 2020

Language: Английский

Citations

186
Microplastic: A potential threat to human and animal health by interfering with the intestinal barrier function and changing the intestinal microenvironment DOI

Zhuizui Huang,

You Weng,

Qichen Shen

et al.

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 785, P. 147365 - 147365

Published: April 27, 2021

Language: Английский

Citations

176
Microbiota and Fatty Liver Disease—the Known, the Unknown, and the Future DOI Creative Commons
Sonja Lang, Bernd Schnabl

Cell Host & Microbe, Journal Year: 2020, Volume and Issue: 28(2), P. 233 - 244

Published: Aug. 1, 2020

Language: Английский

Citations

175
Gut–liver axis: barriers and functional circuits DOI
Oliver Pabst, Mathias W. Hornef, Frank G. Schaap

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 20(7), P. 447 - 461

Published: April 21, 2023

Language: Английский

Citations

166
Immunological mechanisms and therapeutic targets of fatty liver diseases DOI Creative Commons
Hua Wang, Wajahat Z. Mehal, Laura E. Nagy

et al.

Cellular and Molecular Immunology, Journal Year: 2020, Volume and Issue: 18(1), P. 73 - 91

Published: Dec. 2, 2020

Abstract Alcoholic liver disease (ALD) and nonalcoholic fatty (NAFLD) are the two major types of chronic worldwide. Inflammatory processes play key roles in pathogeneses diseases, continuous inflammation promotes progression alcoholic steatohepatitis (ASH) (NASH). Although both ALD NAFLD closely related to inflammation, their respective developmental mechanisms differ some extent. Here, we review multiple immunological therapeutic targets associated with diseases differences ASH NASH. Multiple cell liver, including macrophages, neutrophils, other immune hepatocytes, involved inflammation. In addition, microRNAs (miRNAs), extracellular vesicles (EVs), complement also contribute inflammatory process, as does intertissue crosstalk between intestine, adipose tissue, nervous system. We point out that plays important promoting repair controlling bacterial infections. Understanding complex regulatory process disrupted homeostasis during development may lead improved targeted intervention strategies.

Language: Английский

Citations

155