Liver cirrhosis contributes to the disorder of gut microbiota in patients with hepatocellular carcinoma DOI Creative Commons

Ruipeng Zheng,

Guoqiang Wang, Zhiqiang Pang

et al.

Cancer Medicine, Journal Year: 2020, Volume and Issue: 9(12), P. 4232 - 4250

Published: April 12, 2020

Abstract Background Gut microbiota (GM) of patients with liver cancer is disordered, and syet no study reported the GM distribution cirrhosis‐induced HCC (LC‐HCC) nonliver (NLC‐HCC). In this study, we aimed to characterize gut dysbiosis LC‐HCC NLC‐HCC elucidate role in pathogenesis HCC. Methods A consecutive series fecal samples hepatitis (24 patients), cirrhosis (75 patients: 35 infected by HBV, 25 HCV, 15 alcoholic disease), healthy controls (20 patients) were obtained sequenced on Illumina Hiseq platform. The group contains 52 23 NLC‐HCC. Bioinformatic analysis intestinal was performed QIIME MicrobiomeAnalyst. Results Alpha‐diversity showed that microbial diversity significantly decreased LC group, there significant differences 3 phyla 27 genera vs other groups (the healthy, hepatitis, groups). Beta‐diversity large between others. increased from Characterizing NLC‐HCC, found rather than Thirteen discovered be associated tumor size Three biomarkers ( Enterococcus , Limnobacter Phyllobacterium ) could used for precision diagnosis. We also HBV infection, HCV or ALD (alcoholic disease) not Conclusion Our results suggest disorders are more common LC‐HCC. butyrate‐producing decreased, while producing‐lipopolysaccharide (LPS) patients. Further studies may achieve early diagnosis new therapeutic approaches

Language: Английский

Metabolic reprogramming in the tumor microenvironment of liver cancer DOI Creative Commons
Jian Lin, Dongning Rao, Mao Zhang

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: Jan. 31, 2024

The liver is essential for metabolic homeostasis. onset of cancer often accompanied by dysregulated function, leading to rearrangements. Overwhelming evidence has illustrated that cellular metabolism can, in turn, promote anabolic growth and tumor propagation a hostile microenvironment. In addition supporting continuous survival, disrupted process also creates obstacles the anticancer immune response restrains durable clinical remission following immunotherapy. this review, we elucidate communication between cells their surrounding discuss how reprogramming impacts microenvironment efficacy We describe crucial role gut-liver axis remodeling crosstalk surveillance escape, highlighting novel therapeutic opportunities.

Language: Английский

Citations

41
Biomarkers for diagnosis and therapeutic options in hepatocellular carcinoma DOI Creative Commons

Yau-Tuen Chan,

Cheng Zhang, Junyu Wu

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 6, 2024

Language: Английский

Citations

38
Enhanced capacity of a leaf beetle to combat dual stress from entomopathogens and herbicides mediated by associated microbiota DOI
Yuxin ZHANG,

Handan XU,

Chengjie Tu

et al.

Integrative Zoology, Journal Year: 2024, Volume and Issue: 19(6), P. 1092 - 1104

Published: Feb. 20, 2024

Herbicides have demonstrated their impact on insect fitness by affecting associated microbiota or altering the virulence of entomopathogenic fungi toward insects. However, limited research has explored implications herbicide stress intricate tripartite interaction among insects, bacterial communities, and entomopathogens. In this study, we initially that bacteria confer a leaf beetle, Plagiodera versicolora, with capability to resist fungus Aspergillus nomius infection, sustained even under glyphosate stress. Further analysis revealed significant alteration in abundance composition due treatment. The dominant bacterium, post A. infection following combination treatments, exhibited strong suppressive effects fungal growth. Additionally, markedly inhibited pathogenic bacterium Pseudomonas though it P. versicolora's immunity, ultimately enhancing beetle's tolerance nomius. summary, our findings suggest bestow an augmented resilience against dual stressors both entomopathogen glyphosate. These results provide insight into residues interactions bacteria, fungi, holding for pest control ecosystem assessment.

Language: Английский

Citations

25
Cirrhosis: A Questioned Risk Factor for Hepatocellular Carcinoma DOI
Amanda Garrido, Nabil Djouder

Trends in cancer, Journal Year: 2020, Volume and Issue: 7(1), P. 29 - 36

Published: Sept. 8, 2020

Language: Английский

Citations

101
Liver cirrhosis contributes to the disorder of gut microbiota in patients with hepatocellular carcinoma DOI Creative Commons

Ruipeng Zheng,

Guoqiang Wang, Zhiqiang Pang

et al.

Cancer Medicine, Journal Year: 2020, Volume and Issue: 9(12), P. 4232 - 4250

Published: April 12, 2020

Abstract Background Gut microbiota (GM) of patients with liver cancer is disordered, and syet no study reported the GM distribution cirrhosis‐induced HCC (LC‐HCC) nonliver (NLC‐HCC). In this study, we aimed to characterize gut dysbiosis LC‐HCC NLC‐HCC elucidate role in pathogenesis HCC. Methods A consecutive series fecal samples hepatitis (24 patients), cirrhosis (75 patients: 35 infected by HBV, 25 HCV, 15 alcoholic disease), healthy controls (20 patients) were obtained sequenced on Illumina Hiseq platform. The group contains 52 23 NLC‐HCC. Bioinformatic analysis intestinal was performed QIIME MicrobiomeAnalyst. Results Alpha‐diversity showed that microbial diversity significantly decreased LC group, there significant differences 3 phyla 27 genera vs other groups (the healthy, hepatitis, groups). Beta‐diversity large between others. increased from Characterizing NLC‐HCC, found rather than Thirteen discovered be associated tumor size Three biomarkers ( Enterococcus , Limnobacter Phyllobacterium ) could used for precision diagnosis. We also HBV infection, HCV or ALD (alcoholic disease) not Conclusion Our results suggest disorders are more common LC‐HCC. butyrate‐producing decreased, while producing‐lipopolysaccharide (LPS) patients. Further studies may achieve early diagnosis new therapeutic approaches

Language: Английский

Citations

93