Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
9
Published: Jan. 21, 2021
Wnt
signaling
is
one
of
the
key
pathways
that
govern
numerous
physiological
activities
such
as
growth,
differentiation
and
migration
during
development
homeostasis.
As
pathway
misregulation
has
been
extensively
linked
to
pathological
processes
including
malignant
tumors,
a
thorough
understanding
regulation
essential
for
effective
therapeutic
approaches.
A
prominent
feature
cancer
cells
they
significantly
differ
from
healthy
with
respect
their
plasma
membrane
composition
lipid
organization.
Here,
we
review
role
order
in
activation
by
tightly
regulating
formation
interactions
Wnt-receptor
complex.
We
also
discuss
detail
how
components,
particular
ligands,
(co)receptors
extracellular
or
membrane-bound
modulators,
are
affected
lung,
colorectal,
liver
breast
cancers
have
associated
abnormal
signaling.
complex
components
modulators
frequently
misexpressed
these
this
appears
correlate
metastasis
progression.
Thus,
organization
can
be
exploited
develop
new
anticancer
drugs
targeted
highly
specific
manner
complex,
rendering
more
outcome
possible.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2021,
Volume and Issue:
40(1)
Published: March 1, 2021
Abstract
Single-cell
RNA
sequencing
(scRNA-seq),
a
technology
that
analyzes
transcriptomes
of
complex
tissues
at
single-cell
levels,
can
identify
differential
gene
expression
and
epigenetic
factors
caused
by
mutations
in
unicellular
genomes,
as
well
new
cell-specific
markers
cell
types.
scRNA-seq
plays
an
important
role
various
aspects
tumor
research.
It
reveals
the
heterogeneity
cells
monitors
progress
development,
thereby
preventing
further
cellular
deterioration.
Furthermore,
transcriptome
analysis
immune
tissue
be
used
to
classify
cells,
their
escape
mechanisms
drug
resistance
mechanisms,
develop
effective
clinical
targeted
therapies
combined
with
immunotherapy.
Moreover,
this
method
enables
study
intercellular
communication
interaction
non-malignant
reveal
carcinogenesis.
provides
technical
means
for
development
research
is
expected
make
significant
breakthroughs
field.
This
review
focuses
on
principles
scRNA-seq,
emphasis
application
heterogeneity,
pathogenesis,
treatment.
Experimental & Molecular Medicine,
Journal Year:
2020,
Volume and Issue:
52(12), P. 1898 - 1907
Published: Dec. 1, 2020
Abstract
Hepatocellular
carcinoma
(HCC)
is
the
most
prevalent
primary
liver
cancer
and
a
leading
cause
of
cancer-related
deaths
worldwide.
Ninety
percent
HCC
cases
arise
from
cirrhosis,
during
which
cells
undergo
chronic
cycles
necrosis
regeneration.
The
complex
genomic
landscape
has
been
extensively
investigated
to
draw
correlations
between
recurrently
mutated
pathways
patient
prognosis.
However,
our
limited
success
with
targeted
therapy
shows
that
knowing
presence
somatic
mutations
alone
insufficient
for
us
gauge
full
spectrum
their
functional
consequences
in
context
tumor
evolution.
In
addition,
current
molecular
classification
offers
little
information
on
relationship
features
immunological
properties
tumors
immune
microenvironment.
This
review
introduces
challenges
advancements
made
surveillance,
diagnosis,
treatment.
We
also
discuss
suite
HCC-associated
genetic
changes
describe
recent
studies
provide
evidence
an
evolving
model
its
implications
understanding
targeting
progression.
Molecular Cancer,
Journal Year:
2020,
Volume and Issue:
19(1)
Published: Aug. 10, 2020
Abstract
Background
N6-methyladenosine
(m
6
A)
modification
is
an
emerging
layer
of
epigenetic
regulation
which
widely
implicated
in
the
tumorigenicity
hepatocellular
carcinoma
(HCC),
offering
a
novel
perspective
for
investigating
molecular
pathogenesis
this
disease.
The
role
AlkB
homolog
5
(ALKBH5),
one
m
A
demethylases,
has
not
been
fully
explored
HCC.
Here
we
clarify
biological
profile
and
potential
mechanisms
ALKBH5
Methods
Expression
its
correlation
with
clinicopathological
characteristics
HCC
were
evaluated
using
tissue
microarrays
online
datasets.
And
effects
determined
vitro
vivo.
Subsequently,
methylated
RNA
immunoprecipitation
sequencing
(MeRIP-seq)
combined
(RNA-seq),
following
dot
blot,
MeRIP-qPCR,
RIP-qPCR
or
dual
luciferase
reporter
assays
employed
to
screen
validate
candidate
targets
ALKBH5.
Results
We
demonstrated
that
was
down-regulated
HCC,
decreased
expression
independent
prognostic
factor
worse
survival
patients.
Functionally,
suppressed
proliferation
invasion
capabilities
cells
Mechanistically,
ALKBH5-mediated
demethylation
led
post-transcriptional
inhibition
LY6/PLAUR
Domain
Containing
1
(LYPD1),
could
be
recognized
stabilized
by
effector
IGF2BP1.
In
addition,
identified
LYPD1
induced
oncogenic
behaviors
tumors
contrast
Dysregulation
ALKBH5/LYPD1
axis
impelled
progression
Conclusion
Our
study
reveals
ALKBH5,
characterized
as
tumor
suppressor,
attenuates
via
A-dependent
manner
cells.
findings
enrich
landscape
A-modulated
malignancy,
provide
new
insights
into
biomarkers
therapeutic
treatment.
JHEP Reports,
Journal Year:
2022,
Volume and Issue:
4(6), P. 100479 - 100479
Published: March 26, 2022
Lipids
are
a
complex
and
diverse
group
of
molecules
with
crucial
roles
in
many
physiological
processes,
as
well
the
onset,
progression,
maintenance
cancers.
Fatty
acids
cholesterol
building
blocks
lipids,
orchestrating
these
metabolic
processes.
In
liver,
lipid
alterations
prevalent
cause
consequence
chronic
hepatitis
B
C
virus
infections,
alcoholic
hepatitis,
non-alcoholic
fatty
liver
disease
steatohepatitis.
Recent
developments
lipidomics
have
also
revealed
that
dynamic
changes
triacylglycerols,
phospholipids,
sphingolipids,
ceramides,
acids,
involved
development
progression
primary
cancer.
Accordingly,
transcriptional
landscape
metabolism
suggests
carcinogenic
role
increasing
sterol
synthesis.
However,
limited
mechanistic
insights
into
nature
hepatic
lipidome
so
far
hindered
effective
therapies.
Journal of Clinical Investigation,
Journal Year:
2022,
Volume and Issue:
132(4)
Published: Feb. 14, 2022
Deregulated
Wnt/β-catenin
signaling
is
one
of
the
main
genetic
alterations
in
human
hepatocellular
carcinoma
(HCC).
Comprehensive
genomic
analyses
have
revealed
that
gain-of-function
mutation
CTNNB1,
which
encodes
β-catenin,
and
loss-of-function
AXIN1
occur
approximately
35%
HCC
samples.
Human
HCCs
with
activation
pathway
demonstrate
unique
gene
expression
patterns
pathological
features.
Activated
synergizes
multiple
cascades
to
drive
formation,
it
functions
through
its
downstream
effectors.
Therefore,
strategies
targeting
been
pursued
as
possible
therapeutics
against
HCC.
Here,
we
review
oncogenic
roles
aberrant
during
hepatocarcinogenesis.
In
addition,
discuss
implication
this
diagnosis,
classification,
personalized
treatment.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
10(2)
Published: Nov. 28, 2022
Abstract
Tumor‐associated
macrophages
(TAMs)
play
an
essential
role
in
tumor
progression,
metastasis,
and
antitumor
immunity.
Ferroptosis
has
attracted
extensive
attention
for
its
lethal
effect
on
cells,
but
the
of
ferroptosis
TAMs
impact
progression
have
not
been
clearly
defined.
Using
transgenic
mouse
models,
this
study
determines
that
xCT‐specific
knockout
is
sufficient
to
limit
tumorigenicity
metastasis
HCC
achieved
by
reducing
TAM
recruitment
infiltration,
inhibiting
M2‐type
polarization,
activating
enhancing
activity
within
TAMs.
The
SOCS3‐STAT6‐PPAR‐
γ
signaling
may
be
a
crucial
pathway
macrophage
phenotypic
shifting,
activation
intracellular
associated
with
GPX4/RRM2
regulation.
Furthermore,
xCT‐mediated
significantly
increases
PD‐L1
expression
improves
efficacy
anti‐PD‐L1
therapy
unveiled.
constructed
Man@pSiNPs‐erastin
specifically
targets
protumoral
polarization
combining
treatment
exerts
substantial
efficacy.
xCT
tissues,
especially
CD68+
macrophages,
can
serve
as
reliable
factor
predict
prognosis
patients.
These
findings
provide
further
insight
into
targeting
regulating
infiltration
functional
achieve
precise
prevention
improve
therapeutic
