Hepatic inflammatory responses in liver fibrosis

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 20(10), P. 633 - 646

Published: July 3, 2023

Language: Английский

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Cirrhosis-associated immune dysfunction

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2021, Volume and Issue: 19(2), P. 112 - 134

Published: Oct. 26, 2021

Language: Английский

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Animal models for liver disease – A practical approach for translational research

Journal of Hepatology, Journal Year: 2020, Volume and Issue: 73(2), P. 423 - 440

Published: April 21, 2020

Language: Английский

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Alcohol-associated liver disease

Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(3)

Published: Feb. 1, 2024

Alcohol-associated liver disease (ALD) is a major cause of chronic worldwide, and comprises spectrum several different disorders, including simple steatosis, steatohepatitis, cirrhosis, superimposed hepatocellular carcinoma. Although tremendous progress has been made in the field ALD over last 20 years, pathogenesis remains obscure, there are currently no FDA-approved drugs for treatment ALD. In this Review, we discuss new insights into therapeutic targets ALD, utilizing study multiomics other cutting-edge approaches. The potential translation these studies clinical practice therapy deliberated. We also preclinical models interplay metabolic dysfunction, alcohol-associated cancer, heterogeneity some translational research prospects

Language: Английский

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Macrophage plasticity: signaling pathways, tissue repair, and regeneration

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: Aug. 1, 2024

Abstract Macrophages are versatile immune cells with remarkable plasticity, enabling them to adapt diverse tissue microenvironments and perform various functions. Traditionally categorized into classically activated (M1) alternatively (M2) phenotypes, recent advances have revealed a spectrum of macrophage activation states that extend beyond this dichotomy. The complex interplay signaling pathways, transcriptional regulators, epigenetic modifications orchestrates polarization, allowing respond stimuli dynamically. Here, we provide comprehensive overview the cascades governing focusing on roles Toll‐like receptors, signal transducer activator transcription proteins, nuclear microRNAs. We also discuss emerging concepts metabolic reprogramming trained immunity, contributing their functional adaptability. Macrophage plasticity plays pivotal role in repair regeneration, macrophages coordinating inflammation, angiogenesis, matrix remodeling restore homeostasis. By harnessing potential novel therapeutic strategies targeting polarization could be developed for diseases, including chronic wounds, fibrotic disorders, inflammatory conditions. Ultimately, deeper understanding molecular mechanisms underpinning will pave way innovative regenerative medicine engineering approaches.

Language: Английский

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Cell senescence in liver diseases: pathological mechanism and theranostic opportunity

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(7), P. 477 - 492

Published: March 14, 2024

Language: Английский

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Immunopathobiology and therapeutic targets related to cytokines in liver diseases

Cellular and Molecular Immunology, Journal Year: 2020, Volume and Issue: 18(1), P. 18 - 37

Published: Nov. 17, 2020

Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases cirrhosis hepatocellular carcinoma. The progression of disease is controlled by a variety factors, including injury, inflammatory cells, mediators, cytokines, gut microbiome. In current review, we discuss recent data on large number cytokines that play important roles in regulating inflammation, fibrosis, regeneration, focus interferons T helper (Th) 1, Th2, Th9, Th17, interleukin (IL)-1 family, IL-6 IL-20 family cytokines. Hepatocytes also produce certain (such as IL-7, IL-11, IL-33), functions these are briefly summarized. Several have great therapeutic potential, some currently being tested targets clinical trials for treatment diseases, which described.

Language: Английский

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Leukocytes, Systemic Inflammation and Immunopathology in Acute-on-Chronic Liver Failure

Cells, Journal Year: 2020, Volume and Issue: 9(12), P. 2632 - 2632

Published: Dec. 8, 2020

Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with cirrhosis and characterized by acute decompensation, organ failure(s) high short-term mortality. ACLF frequently occurs close temporal relationship to precipitating event, such as alcoholic, drug-induced or viral hepatitis bacterial infection and, cases without events, probably related intestinal translocation of products. Dysbalanced immune function central its pathogenesis outcome an initial excessive systemic inflammatory response drives This hyperinflammatory state ultimately impairs the host defensive mechanisms cells, rendering immunocompromised more vulnerable secondary infections, therefore higher dysfunction In this review, we describe prevailing characteristics acutely decompensated developing ACLF, special emphasis on cells innate system (i.e., monocytes neutrophils), their triggers (pathogen- damage-associated molecular patterns [PAMPs DAMPs]), effector molecules (cytokines, chemokines, growth factors bioactive lipid mediators) consequences tissue immunopathology. addition, review includes chapter discussing new emerging therapies based modulation leukocyte administration pleiotropic proteins albumin, Toll-like receptor 4 antagonists, interleukin-22 stem cell therapy. Finally, importance finding appropriate intervention reduces inflammation inducing immunosuppression highlighted one main therapeutic challenges cirrhosis.

Language: Английский

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Interplay of cardiovascular mediators, oxidative stress and inflammation in liver disease and its complications

Nature Reviews Cardiology, Journal Year: 2020, Volume and Issue: 18(2), P. 117 - 135

Published: Sept. 30, 2020

Language: Английский

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Acute-on-chronic liver failure: A distinct clinical syndrome

Journal of Hepatology, Journal Year: 2021, Volume and Issue: 75, P. S27 - S35

Published: May 23, 2021

Language: Английский

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