Journal of Gastroenterology and Hepatology, Journal Year: 2020, Volume and Issue: 35(12), P. 2041 - 2050

Published: June 23, 2020

Lean non-alcoholic fatty liver disease (NAFLD) is a potentially metabolically unhealthy state that refers to NAFLD occurring in non-overweight/nonobese subjects. Yet its global epidemiology and metabolic characteristics are not extensively elucidated.PubMed, EMBASE, Web of Science Cochrane databases were searched for eligible studies until January 2020. Random-effects/fixed-effects models used estimate the prevalence lean compare clinical among non-NAFLD, NAFLD, overweight/obese "Lean" was defined by ethnic-specific body mass index measurements normal range. Meta-regression subgroup analyses performed determine potential sources heterogeneity.A total 33 observational included with 205 307 individuals from 14 countries. The 4.1% (95% confidence interval [CI]: 3.4-4.8%). In subjects, 9.7% CI: 7.7-11.8%). diabetes, hypertension, syndrome, dyslipidemia, or central obesity 0.6% 0.4-0.9%), 1.8% 1.2-2.5%), 1.4% 1.0-1.9%), 2.8% 1.9-3.7%), 2.0% 1.6-2.4%), respectively. showed an upward trend between 1988 2017. Asian had highest (4.8%, 95% 4.0-5.6%). Middle-aged people (45-59 years old) (4.4%, 3.2-5.5%). complications groups increased sequentially.Lean occurs uncommon condition. middle-aged

Language: Английский