Adlercreutzia equolifaciens Is an Anti-Inflammatory Commensal Bacterium with Decreased Abundance in Gut Microbiota of Patients with Metabolic Liver Disease

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12232 - 12232

Published: July 31, 2023

Non-alcoholic fatty liver disease (NAFLD) affects about 20-40% of the adult population in high-income countries and is now a leading indication for transplantation can lead to hepatocellular carcinoma. The link between gut microbiota dysbiosis NAFLD clearly established. Through analyses with shotgun metagenomics, we observe that compared healthy controls, Adlercreutzia equolifaciens depleted patients diseases such as NAFLD. Its abundance also decreases progresses eventually disappears last stages indicating strong association severity. Moreover, show A. possesses anti-inflammatory properties, both vitro vivo humanized mouse model Therefore, our results demonstrate severity presence its actions. Counterbalancing this bacterium may be promising live biotherapeutic strategy diseases.

Language: Английский

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Remnant cholesterol has a non-linear association with non-alcoholic fatty liver disease

Diabetes Research and Clinical Practice, Journal Year: 2023, Volume and Issue: 201, P. 110733 - 110733

Published: May 26, 2023

Language: Английский

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Increases and decreases in liver stiffness measurement are independently associated with the risk of liver-related events in NAFLD

Journal of Hepatology, Journal Year: 2024, Volume and Issue: 81(4), P. 600 - 608

Published: May 16, 2024

Language: Английский

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Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 24, 2024

Abstract A lasting imbalance between fatty acid synthesis and consumption leads to non-alcoholic liver disease (NAFLD), coupled with hepatitis insulin resistance. Yet the details of underlying mechanisms are not fully understood. Here, we unraveled that expression transcription factor Zbtb18 is markedly decreased in livers both patients murine models NAFLD. Hepatic knockout promoted NAFLD features like impaired energy expenditure oxidation (FAO), induced Conversely, hepatic overexpression alleviated hepato-steatosis, resistance, hyperglycemia mice fed on a high-fat diet (HFD) or diabetic mice. Notably, vitro vivo mechanistic studies revealed transcriptional activation Farnesoid X receptor ( FXR ) mediated FAO Clathrin Heavy Chain CLTC protein hinders NLRP3 inflammasome activity. This key mechanism by which hepatocyte’s alleviates consequent fibrosis was further verified FXR’ s deletion forced cultured mouse primary hepatocytes (MPHs). Moreover, significantly abrogated overexpression-driven inhibition activity macrophages. Altogether, transcriptionally activates -mediated expression, inhibits inflammasome’s alleviating inflammatory stress representing an attractive remedy for steatosis fibrosis.

Language: Английский

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MASLD/MASH and type 2 diabetes: Two sides of the same coin? From single PPAR to pan-PPAR agonists

Diabetes Research and Clinical Practice, Journal Year: 2024, Volume and Issue: 212, P. 111688 - 111688

Published: May 1, 2024

Language: Английский

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