Journal of Hepatology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
The
clinical
utility
of
thrombomodulin-modified
thrombin
generation
(TM-TG)
in
cirrhosis
is
uncertain.
We
conducted
a
prospective
study
to
evaluate
the
prognostic
value
TM-TG
cirrhosis.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 459 - 459
Published: Jan. 8, 2025
Low-grade
chronic
inflammation
may
impact
liver
disease.
We
investigated
the
extent
to
which
circulating
GlycA,
a
glycoprotein
biomarker
of
low-grade
inflammation,
and
high-sensitivity
C-reactive
protein
(hs-CRP)
are
altered
in
patients
with
cirrhosis
transplant
recipients
(LTRs)
examined
their
associations
all-cause
mortality.
Plasma
GlycA
(nuclear
magnetic
resonance
spectroscopy)
hs-CRP
(nephelometry)
were
assessed
129
on
waiting
list
for
transplantation
367
LTRs
(TransplantLines
cohort
study;
NCT03272841)
compared
4837
participants
from
population-based
PREVEND
cohort.
levels
lower,
while
higher
(p
<
0.001).
Notably,
increased,
but
decreased
after
transplantation.
In
LTRs,
both
than
Survival
was
impaired
highest
tertiles.
Cox
regression
analysis,
remained
associated
mortality
cirrhotic
adjusting
potential
confounders
(HR
per
1-SD
increment:
2.34
[95%
CI
1.07-5.13]),
association
lost.
also
(adjusted
HR:
1.60
CI:
1.2-2.14]
1.64
1.08-2.51],
respectively)
not
independent
each
other.
increases
decreases
Both
inflammatory
markers
be
seems
at
least
as
strong
that
hs-CRP.
