Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(12), P. 1192 - 1199
Published: Jan. 1, 2024
Language: Английский
Metabolites, Journal Year: 2024, Volume and Issue: 14(6), P. 324 - 324
Published: June 7, 2024
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common condition with heterogeneous outcomes difficult to predict at the individual level. Feared complications of advanced MASLD are linked clinically significant portal hypertension and initiated by functional mechanical changes in unique sinusoidal capillary network liver. Early vasoregulatory lead increased intrahepatic vascular resistance represent beginning hypertension. In addition, composition function gut microbiota distinctly different from healthy state, multiple lines evidence demonstrate association dysbiosis these changes. The involved biotransformation nutrients, production de novo metabolites, release microbial structural components, impairment intestinal barrier impact on innate immune responses, metabolism, inflammation, fibrosis, vasoregulation beyond. gut–liver axis conceptual framework which circulation primary connection between Accordingly, biochemical hemodynamic attributes may hold key better understanding predicting progression MASLD. However, many specific details remain hidden due limited access circulation, indicating major unmet need for development innovative diagnostic tools analyze metabolites explore their effect health disease. We also safely reliably monitor hemodynamics goal providing preventive curative interventions all stages Here, we review recent advances that link metabolomics altered allow new insights into
Language: Английский
Citations
4
Current Hepatology Reports, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 8, 2025
Language: Английский
Citations
0
Journal of Digestive Diseases, Journal Year: 2025, Volume and Issue: unknown
Published: March 2, 2025
Language: Английский
Citations
0
Zeitschrift für Gastroenterologie, Journal Year: 2025, Volume and Issue: unknown
Published: April 30, 2025
With the rapid development of endoscopic ultrasound (EUS), diagnostic and therapeutic platforms have emerged that are applicable in hepatology. New tools such as EUS-guided portal pressure measurement (in combination with liver biopsy) or variceal obliteration using coils glue present attractive procedures can potentially overcome limitations current gold standards. In this review article, we provide an overview these new 'endo-hepatology' techniques highlight their role treatment diseases.
Language: Английский
Citations
0
Therapeutic Advances in Gastroenterology, Journal Year: 2024, Volume and Issue: 17
Published: Jan. 1, 2024
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing public health concern worldwide. Liver biopsy the gold standard for diagnosing and staging MASLD, but it invasive carries associated risks. In recent years, there has been significant progress in developing noninvasive techniques evaluation. This review article discusses briefly current available assessments various including such as transjugular transcutaneous needle biopsy, intraoperative/laparoscopic evolving role of endoscopic ultrasound-guided biopsy. addition to discussing techniques, we state knowledge on histopathologic evaluation scoring systems used grade stage disease. We also explore alternative modalities evaluation, whole slide imaging utility immunohistochemistry. Overall, this provides comprehensive overview MASLD compares modalities. However, beyond clinical trials, practical application may be limited, ongoing advancements fibrosis are expected more effectively identify candidates treatment real-world settings.
Language: Английский
Citations
3
Journal of Hepatology, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(43), P. 4602 - 4608
Published: Oct. 31, 2024
Esophageal variceal bleeding is a severe complication often associated with portal hypertension, commonly due to liver cirrhosis. Prevention and treatment of this condition are critical for patient outcomes. Preventive strategies focus on reducing hypertension prevent varices from developing or enlarging. Primary prophylaxis involves the use non-selective beta-blockers, such as propranolol nadolol, which lower pressure by decreasing cardiac output thereby blood flow varices. Endoscopic ligation (EVL) may also be employed primary initial episodes. Once occurs, immediate essential. Initial management includes hemodynamic stabilization followed pharmacological therapy vasoactive drugs octreotide terlipressin control bleeding. intervention cornerstone treatment, techniques EVL sclerotherapy applied directly manage In cases where refractory endoscopic transjugular intrahepatic portosystemic shunt considered effectively reduce pressure. Long-term after an acute episode secondary using beta-blockers repeated sessions rebleeding, complemented monitoring managing function address underlying disease. light new scientific evidence, including findings study Peng et al , editorial aims review available prevention esophageal
Language: Английский
Citations
2
Digestive and Liver Disease, Journal Year: 2023, Volume and Issue: 56(7), P. 1185 - 1195
Published: Dec. 26, 2023
Language: Английский
Citations
6
Eurasian Journal of Medicine, Journal Year: 2024, Volume and Issue: 55(S1), P. 131 - 137
Published: Feb. 28, 2024
In recent years, significant advances have been made in endoscopic ultrasonography (EUS) processors, transducers, and the instruments used. parallel with these developments, importance of EUS diagnosis, treatment, management chronic liver diseases has increased considerably. One most important advantages is that ultrasound probe can examine area under examination from a very close distance. Additionally, provides ability to provide excellent spatial files realtime images; Doppler, elastography, contrast methods are also widely used increase diagnostic accuracy evaluations. Endoscopic ultrasound-guided procedures an alternative method when percutaneous approaches not feasible. ultrasound-based advanced applications such as EUSguided biopsy (LB), EUS-guided ascites assessment, use evaluation focal lesions liver, portal pressure gradient (EUS-PPG) measurements becoming increasingly common important. As result developments devices instruments, it possible perform all hepatology EUS. other words, imaging interventional hepatologist would require for diagnosis single session, without need any expertise than gastroenterologist (such radiologist, or surgeon). This called single-procedure approach, "all one" hepatology. From hepatologist's perspective, be thought "hepatologist's Swiss army knife."
Language: Английский
Citations
1
Diagnostics, Journal Year: 2024, Volume and Issue: 14(11), P. 1155 - 1155
Published: May 31, 2024
Background: Focal liver lesions (FLL) often require cytohistological evaluation. Endoscopic Ultrasound (EUS)-guided tissue acquisition (EUS-TA) is highly accurate in diagnosing pancreatic and gastrointestinal malignancies. The aim of our study was to evaluate the role EUS-TA characterization FLL. Methods: A retrospective analysis a prospective database patients who underwent for evaluation Diagnostic yield, adverse events factors associated with diagnostic yield were evaluated as endpoints. effect variables such needle size, lesion rapid on-site (ROSE) use cytological or histological needles analyzed. Results: total 114 cases included (mean age 68.05 ± 11.35 years, 64 male). correct diagnosis made using 100 (diagnostic 88%). additional extrahepatic during same EUS procedure increased 94%. No reported. Multivariate did not identify any factor influencing yield. Conclusions: safe technique differential FLL could be considered primary approach this setting.
Language: Английский
Citations
1