Outcomes of Various Classes of Oral Antidiabetic Drugs on Nonalcoholic Fatty Liver Disease

JAMA Internal Medicine, Journal Year: 2024, Volume and Issue: 184(4), P. 375 - 375

Published: Feb. 12, 2024

Importance Several oral antidiabetic drug (OAD) classes can potentially improve patient outcomes in nonalcoholic fatty liver disease (NAFLD) to varying degrees, but clinical data on which class is favored are lacking. Objective To investigate OAD associated with the best NAFLD and type 2 diabetes (T2D). Design, Setting, Participants This retrospective nonrandomized interventional cohort study used National Health Information Database, provided population-level for Korea. involved patients T2D concomitant NAFLD. Exposures Receiving either sodium-glucose cotransporter (SGLT2) inhibitors, thiazolidinediones, dipeptidyl peptidase-4 (DPP-4) or sulfonylureas, each combined metformin 80% more of 90 consecutive days. Main Outcomes Measures The main were regression assessed by index composite liver-related outcome (defined as hospitalization, mortality, transplant, hepatocellular carcinoma) using Fine-Gray model regarding competing risks. Results In total, 80 178 (mean [SD] age, 58.5 [11.9] years; 43 007 [53.6%] male) followed up 219 941 person-years, 4102 experiencing regression. When compared SGLT2 inhibitors (adjusted subdistribution hazard ratio [ASHR], 1.99 [95% CI, 1.75-2.27]), thiazolidinediones (ASHR, 1.70 1.41-2.05]), DPP-4 1.45 1.31-1.59]) a higher likelihood when 1.40 1.12-1.75]) 1.30-1.62]). Only 0.37 0.17-0.82]), not significantly lower incidence rates adverse sulfonylureas. Conclusions Relevance results this suggest that physicians may lean towards prescribing preferred individuals T2D, considering their potential benefits incidences outcomes. observational should prompt future research determine whether practices might merit reexamination.

Language: Английский

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NLRP3 inflammasome pathway involved in the pathogenesis of metabolic associated fatty liver disease

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 23, 2024

Abstract The prevalence of Metabolic-associated fatty liver disease (MAFLD) has been steadily increasing worldwide, paralleling the global epidemic obesity and diabetes. It is estimated that approximately one-quarter population affected by MAFLD. Despite its high prevalence, MAFLD often goes undiagnosed due to lack specific symptoms in early stages. However, as progresses, it can lead more severe liver-related complications such fibrosis, cirrhosis, hepatocellular carcinoma. Therefore, we aimed investigate expression levels nucleotide-binding oligomerization domain, leucine-rich repeat (LRR)—containing proteins (NLR) family pyrin domain-containing protein 3 [NLRP3] inflammasome pathway components, NLRP3 interleukin 1β (IL-1β) genes patients with various degrees steatosis fibrosis. Participants were classified into two equal groups; group: consisted 120 different hepatic fibrosis based on fibro scan results. non-MAFLD group was comprised 107 participants. Molecular analysis IL-1β relative gene expressions performed blood all participants, using Real-time quantitative polymerase chain reaction (RT-qPCR). Patients post-MAFLD had significantly higher NLRP3; > 1.1 AUC 0.919, sensitivity 88.33, specificity 96.26, PPV 96.4, NPV 88 92.3 accuracy ( p value < 0.001). 1.33 a 97.5, 99.07, 99.2, 97.2, 98.3 an 0.991 0.001) predictors fibrosis.. A significant increase mean both found (F0-F1-2); 31.97 ± 11.8 6.76 2.18, respectively; compared advanced stages (F2-F3); 2.62 3.71 4.27 2.99 0.001 each). present study provides novel evidence for possible involvement metabolic-associated pathogenesis could be valid markers detection

Language: Английский

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Associations of Metabolic Dysfunction-Related Fatty Liver Disease and Dementia risk: A Prospective Study Based on the UK Biobank

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: unknown, P. 105845 - 105845

Published: March 1, 2025

Language: Английский

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Evaluation of Nomenclature of Fatty Liver Disease in Association with Hepatocellular Carcinoma: A 15.5-Year Cohort Study in Korea

Published: Jan. 1, 2024

Language: Английский

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Reply to: “Longitudinal changes in fatty liver index are associated with risk of hepatocellular carcinoma: A nationwide cohort study in Korea”

Journal of Hepatology, Journal Year: 2024, Volume and Issue: 80(5), P. e218 - e219

Published: Feb. 2, 2024

Language: Английский

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