Macrophage polarization and its impact on idiopathic pulmonary fibrosis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 26, 2024

Idiopathic pulmonary fibrosis (IPF) is a lung disease that worsens over time, causing in the lungs and ultimately resulting respiratory failure high risk of death. Macrophages play crucial role immune system, showing flexibility by transforming into either pro-inflammatory (M1) or anti-inflammatory (M2) macrophages when exposed to different stimuli, impacting development IPF. Recent research has indicated polarization onset progression M1 secrete inflammatory cytokines agents early damage fibrosis, while M2 support tissue healing releasing cytokines. Developing novel treatments for IPF relies on thorough comprehension processes involved macrophage The review outlines regulation its impact IPF, with goal investigating possible therapeutic benefits advancement

Language: Английский

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Multi-omics and chemical profiling approaches to understand the material foundation and pharmacological mechanism of sophorae tonkinensis radix et rhizome-induced liver injury in mice

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 330, P. 118224 - 118224

Published: April 19, 2024

Language: Английский

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Role of pattern recognition receptors in the development of MASLD and potential therapeutic applications

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116724 - 116724

Published: May 17, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) has become one of the most prevalent diseases worldwide, and its occurrence is strongly associated with obesity, insulin resistance (IR), genetics, metabolic stress. Ranging from simple fatty to steatohepatitis (MASH), even severe complications such as fibrosis advanced cirrhosis or hepatocellular carcinoma, underlying mechanisms MASLD progression are complex involve multiple cellular mediators related signaling pathways. Pattern recognition receptors (PRRs) innate immune system, including Toll-like (TLRs), C-type lectin (CLRs), NOD-like (NLRs), RIG-like (RLRs), DNA receptors, have been demonstrated potentially contribute pathogenesis for MASLD. Their pathways can induce inflammation, mediate oxidative stress, affect gut microbiota balance, ultimately resulting in hepatic steatosis, inflammatory injury fibrosis. Here we review available literature regarding involvement PRR-associated signals pathogenic clinical features MASLD, vitro animal models We also discuss emerging targets PRRs drug developments that involved agent therapies intended arrest reverse progression, thus enabling refinement therapeutic accelerate development.

Language: Английский

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Exercise promotes peripheral glycolysis in skeletal muscle through miR-204 induction via the HIF-1α pathway

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 9, 2025

The mechanisms underlying exercise-induced insulin sensitization are of great interest, as exercise is a clinically critical intervention for diabetic patients. Some microRNAs (miRs) secreted from skeletal muscle after where they regulate sensitivity, and have potential diagnostic markers in miR-204 well-known its involvement development, cancer, metabolism; however, role glycemic control remains unclear. In the present study, endurance mice increased expression levels muscle. chronic model, were elevated along with glycolytic enzymes When muscular hypoxia was induced exercise, also upregulation hypoxia-inducible factor 1-alpha (HIF-1α). Furthermore, HIF-1α overexpression led to expression. Treatment mimic C2C12 cells significantly enhanced glycolysis rate mRNA enzymes. Notably, intravenous administration glucose clearance following refeeding. initially blood at an early stage refeeding but later promoted reduction continued. Additionally, upregulated muscles miR-204-injected mice. These findings suggest novel physiological promoting glycolysis, particularly situations action limited.

Language: Английский

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Advancing precision medicine in metabolic dysfunction-associated steatotic liver disease

Trends in Endocrinology and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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E2F2 Reprograms Macrophage Function By Modulating Material and Energy Metabolism in the Progression of Metabolic Dysfunction‐Associated Steatohepatitis

Advanced Science, Journal Year: 2024, Volume and Issue: 11(48)

Published: Oct. 28, 2024

Abstract Macrophages are essential for the development of steatosis, hepatic inflammation, and fibrosis in metabolic dysfunction‐associated steatohepatitis(MASH). However, roles macrophage E2F2 progression MASH have not been elucidated. This study reveals that expression is dramatically downregulated livers from mice humans, this adversely correlated with severity disease. Myeloid‐specific depletion aggravates intrahepatic stellate cell activation, hepatocyte lipid accumulation during progression. Mechanistically, can inhibit SLC7A5 transcription directly. deficiency upregulates to mediate amino acids flux, resulting enhanced glycolysis, impaired mitochondrial function, increased macrophages proinflammatory response a Leu‐mTORC1‐dependent manner. Moreover, bioinformatics analysis CUT &Tag assay identify direct binding Nrf2 promoter promote its nuclear translocation. Genetic or pharmacological activation effectively activates attenuate Finally, patients treated CDK4/6 inhibitors demonstrate reduced activity but PBMCs. These findings indicated suppresses by reprogramming acid metabolism via SLC7A5‐ Leu‐mTORC1 signaling pathway. Activating holds promise as therapeutic strategy MASH.

Language: Английский

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Processed Buthus martensii Karsch scorpions ameliorate diet-induced NASH in mice by attenuating Kv1.3-mediated macrophage activation

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118794 - 118794

Published: Sept. 6, 2024

Language: Английский

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Lipotoxicity-driven metabolic dysfunction-associated steatotic liver disease (MASLD)

Atherosclerosis, Journal Year: 2024, Volume and Issue: 400, P. 119053 - 119053

Published: Nov. 14, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a spectrum of lesions, ranging from simple steatosis to metabolic steatohepatitis (MASH), that may further progress cirrhosis. MASLD is estimated affect more than one third the general population and it represents risk factor for end-stage failure cancer, substantially contributing liver-related morbidity mortality. Although pathogenesis incompletely understood, known consist multifactorial process influenced by extrinsic intrinsic factors such as metabolic, environmental demographic features, gut microbiota genetics. Dysregulation both extracellular intracellular lipid composition promote generation toxic species, thereby triggering lipotoxicity cellular stress. These events ultimately lead activation distinct cell death pathways, resulting in inflammation, fibrogenesis and, eventually, carcinogenesis. In this manuscript, we provide comprehensive review role during pathogenesis, discussing most relevant species related molecular mechanisms, summarizing type-specific effects highlighting promising putative therapeutic strategies modulating metabolism MASLD.

Language: Английский

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Whole-Transcriptome Analysis Reveals Potential CeRNA Regulatory Mechanism in Takifugu rubripes against Cryptocaryon irritans Infection

Biology, Journal Year: 2024, Volume and Issue: 13(10), P. 788 - 788

Published: Oct. 1, 2024

Cryptocaryon irritans (C. irritans) is a proto-ciliate parasite that infects marine fishes, including the cultured species Takifugu rubripes (T. rubripes), causing disease and potential mortality. In host organisms, infection by parasites triggers an immune response modulated regulatory elements proteins non-coding RNAs. this study, whole transcriptome RNA sequencing of T. gill tissue before after with C. was performed to reveal competitive endogenous (ceRNA) network. Histomorphology revealed segment swelling parasitic invasion in infected group. The analysis identified 18 differentially expressed miRNAs (DEMs), 214 lncRNAs (DELs), 2501 genes (DEGs), 7 circRNAs (DECs) Gene Ontology (GO) enrichment these were notably enriched Wnt signaling pathway mTOR pathway. co-expression networks (lncRNA/circRNA-miRNA-mRNA) constructed based on correlation Further suggested LOC105418663-circ_0000361-fru-miR-204a-fzd3a ceRNA axis potentially involved regulation responses against infection. Finally, expression levels DEG, DEL, DEM validated. This study reveals mechanism candidate network, providing insights into rubripes’ irritans.

Language: Английский

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