BMI gain and dietary characteristics are risk factors of MASLD in non-obese individuals DOI Creative Commons
Hirokazu Taniguchi,

Miho Ueda,

Yukio Kobayashi

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 21, 2025

Abstract This longitudinal observational study aimed to evaluate whether cardiometabolic factors and dietary characteristics are determinants of metabolic dysfunction-associated steatotic liver disease (MASLD) in non-obese individuals (body mass index [BMI] < 25 kg/m²). The was conducted at the Japanese Red Cross Society Kyoto Daiichi Hospital. Clinical data were longitudinally recorded annual health checks. diagnosis MASLD based on results abdominal ultrasonography criteria. Lifestyle behaviors assessed using a self-administered questionnaire. A total 4,100 middle-aged older participants (1,636 men 2,464 women) followed up for an average 6.44 ± 4.16 years. During follow-up period, there 410 new cases (25.1%) 484 women (19.6%). incidence rate higher (39.7 per 1,000 person-years) than (30.1 person-years). Multivariable-adjusted logistic regression analyses change year with standardized values found that BMI gain strongly associated onset both (OR: 1.90, 95% CI: 1.64–2.19) 1.95, 1.72–2.21). Increased waist circumference triglycerides also women. Lowering high-density lipoprotein cholesterol identified as risk factor Regarding characteristics, significantly negatively “often eating vegetables” 0.73, 0.57–0.93) soy products” 0.71, 0.58–0.88), even after adjusting other covariates. These findings suggest maintaining body weight favorable key prevention individuals.

Language: Английский

BMI gain and dietary characteristics are risk factors of MASLD in non-obese individuals DOI Creative Commons
Hirokazu Taniguchi,

Miho Ueda,

Yukio Kobayashi

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 21, 2025

Abstract This longitudinal observational study aimed to evaluate whether cardiometabolic factors and dietary characteristics are determinants of metabolic dysfunction-associated steatotic liver disease (MASLD) in non-obese individuals (body mass index [BMI] < 25 kg/m²). The was conducted at the Japanese Red Cross Society Kyoto Daiichi Hospital. Clinical data were longitudinally recorded annual health checks. diagnosis MASLD based on results abdominal ultrasonography criteria. Lifestyle behaviors assessed using a self-administered questionnaire. A total 4,100 middle-aged older participants (1,636 men 2,464 women) followed up for an average 6.44 ± 4.16 years. During follow-up period, there 410 new cases (25.1%) 484 women (19.6%). incidence rate higher (39.7 per 1,000 person-years) than (30.1 person-years). Multivariable-adjusted logistic regression analyses change year with standardized values found that BMI gain strongly associated onset both (OR: 1.90, 95% CI: 1.64–2.19) 1.95, 1.72–2.21). Increased waist circumference triglycerides also women. Lowering high-density lipoprotein cholesterol identified as risk factor Regarding characteristics, significantly negatively “often eating vegetables” 0.73, 0.57–0.93) soy products” 0.71, 0.58–0.88), even after adjusting other covariates. These findings suggest maintaining body weight favorable key prevention individuals.

Language: Английский

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