Journal of Hepatology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Eurosurveillance, Journal Year: 2025, Volume and Issue: 30(12)
Published: March 27, 2025
BackgroundRat hepatitis E virus (ratHEV) is an emerging causing acute and chronic in humans. Rats are the main natural reservoir of this pathogen. Large-scale studies assessing ratHEV circulation rodents Spain lacking.AimWe aimed to determine prevalence rats evaluate potential transmission risk humans.MethodsWe designed a cross-sectional nationwide study where black (Rattus rattus) Norway (R. norvegicus) were collected analysed between 2022 2023 for infection using real-time (RT)-qPCR testing liver tissue. Sequencing analysis shedding faeces carried out positive animals.ResultsRatHEV was detected 125 481 analysed, supposing 26.0% (95 CI%: 22.3-30.1). Positive found urban (25.6%), farm (29.8%) settings. Black (31.3%) had 1.5 times higher odds being infected by than (22.5%) (p = 0.049). Significantly sampled from southern (31.9%) northern (17.8%) 0.003). Viral RNA 45.5% rats. Phylogenetic evidenced wide genetic diversity sequences, some showing high homology with strains patients Spain.ConclusionsCirculation appears be heterogeneous endemic among rat populations Spain, highlighting possible zoonotic country.
Language: Английский
Citations
0
Emerging Microbes & Infections, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
We previously observed a notable discrepancy in the distribution of HEV-3 subtypes between wastewater and clinical samples Sweden. To confirm this observation comprehensively elucidate circulation patterns across humans, animals, environmental waters Sweden, we analyzed HEV genetic diversity archived late 2016 early 2018, cases 2012 2024, all available Swedish sequences from NCBI Virus database. RNA was detected samples, with subtype 3c being only identified. In typed cases, 3f (45/126) (44/126) were nearly equally distributed, though regional dominance varied. When incorporating human other studies, became dominant (75/168). Analysis revealed that (113/136) Sus scrofa (pigs wild boars), while (30/33) waters. These findings highlight complex transmission dynamics The near-absence domestic pigs boars, despite its high proportion raises question about source infection. addition, near-exclusive detection suggests potential differences viral shedding, disease severity subtypes, or alternative host sources. This study emphasizes importance integrated One Health surveillance to track reservoirs.
Language: Английский
Citations
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Journal of Hepatology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Hepatology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0