Vestnik Moskovskogo universiteta Seria 16 Biologia,
Journal Year:
2024,
Volume and Issue:
79(№4, 2024), P. 315 - 321
Published: Jan. 1, 2024
Systemic
chronic
inflammation
(SCI)
can
develop
due
to
diabetes
mellitus,
coronary
artery
disease,
atherosclerosis,
autoimmune
diseases,
kidney,
liver,
and
lung
pathologies,
cancer,
etc.
During
the
COVID-19
pandemic,
there
was
clear
evidence
showing
that
damages
endothelial
cells
of
vascular
wall,
leading
impaired
microcirculation.
Currently,
mechanisms
causing
pathological
changes
in
brain
amid
SCI
are
still
unclear.
In
this
work,
we
investigated
how
systemic
affects
vasodilatory
function
cerebral
arteries.
modeled
using
well-established
cecal
ligation
puncture
model,
which
involves
tying
off
cecum
below
ileocecal
valve
puncturing
it
with
a
needle.
For
characterizing
model
animals,
recorded
body
weight,
blood
pressure,
analyzed
levels
leukocytes,
ESR,
hematocrit,
erythrocyte
aggregation
arterial
blood,
number
desquamated
venous
blood.
The
density
network
pial
membrane
reactivity
studied
vivo
microvascular
imaging.
vessels
per
unit
area
diameter
under
influence
vasoactive
substances
–
aminoguanidine
(an
inducible
NO-synthase
inhibitor)
acetylcholine
were
measured.
From
7
days
3
months
after
onset
SCI,
leukocyte
rat
increased
by
2.1–1.7
times
compared
control
group.
1.8
control.
Erythrocyte
rose
an
average
1.3
times.
decreased
1.7
constrictions
arteries
induced
1.5
3.7
expanded
response
4.9
Thus,
over
period
three
leads
decrease
deterioration
vasomotor
Journal of Clinical and Translational Hepatology,
Journal Year:
2024,
Volume and Issue:
000(000), P. 000 - 000
Published: Sept. 30, 2024
Early
determination
of
prognosis
in
patients
with
acute-on-chronic
liver
failure
(ACLF)
is
crucial
for
optimizing
treatment
options
and
allocation.
This
study
aimed
to
identify
risk
factors
associated
ACLF
develop
new
prognostic
models
that
accurately
predict
patient
outcomes.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(12), P. e0315619 - e0315619
Published: Dec. 26, 2024
Background
&
aims
Acute-on-chronic
liver
failure
is
a
syndrome
characterized
by
organ
and
high
short-term
mortality.
The
lack
of
reliable
biomarkers
for
the
early
detection
acute-on-chronic
significant
challenge.
Endothelial
dysfunction
plays
key
role
in
development
failure.
Serum
endocan
potential
new
biomarker
endothelial
dysfunction.
Therefore,
this
study
aimed
to
assess
association
between
28-day
mortality
patients
with
cirrhosis.
Methods
Hospitalized
cirrhosis
without
were
prospectively
enrolled
according
criteria
European
Association
Study
Liver-Chronic
Liver
Failure
consortium.
comparative
performances
serum
endocan,
procalcitonin,
interleukin-6
diagnosing
predicting
studied.
Results
included
116
hospitalized
cirrhosis,
55
whom
had
on
admission.
Patients
significantly
higher
levels
than
those
it.
At
cut-off
value
15.8
ng/mL,
showed
sensitivity
63.6%
specificity
67.2%
diagnosis
failure,
an
area
under
receiver
operating
characteristic
curve
0.65,
which
comparable
procalcitonin
interleukin-6.
Multivariate
analysis
identified
creatinine,
total
bilirubin
as
independent
factors
who
died
within
28
days
baseline
survived.
hospital-acquired
infection,
mechanical
ventilator
use,
≥37
pg/mL
predictors
Conclusion
associated
risk
factor
Vestnik Moskovskogo universiteta Seria 16 Biologia,
Journal Year:
2024,
Volume and Issue:
79(№4, 2024), P. 315 - 321
Published: Jan. 1, 2024
Systemic
chronic
inflammation
(SCI)
can
develop
due
to
diabetes
mellitus,
coronary
artery
disease,
atherosclerosis,
autoimmune
diseases,
kidney,
liver,
and
lung
pathologies,
cancer,
etc.
During
the
COVID-19
pandemic,
there
was
clear
evidence
showing
that
damages
endothelial
cells
of
vascular
wall,
leading
impaired
microcirculation.
Currently,
mechanisms
causing
pathological
changes
in
brain
amid
SCI
are
still
unclear.
In
this
work,
we
investigated
how
systemic
affects
vasodilatory
function
cerebral
arteries.
modeled
using
well-established
cecal
ligation
puncture
model,
which
involves
tying
off
cecum
below
ileocecal
valve
puncturing
it
with
a
needle.
For
characterizing
model
animals,
recorded
body
weight,
blood
pressure,
analyzed
levels
leukocytes,
ESR,
hematocrit,
erythrocyte
aggregation
arterial
blood,
number
desquamated
venous
blood.
The
density
network
pial
membrane
reactivity
studied
vivo
microvascular
imaging.
vessels
per
unit
area
diameter
under
influence
vasoactive
substances
–
aminoguanidine
(an
inducible
NO-synthase
inhibitor)
acetylcholine
were
measured.
From
7
days
3
months
after
onset
SCI,
leukocyte
rat
increased
by
2.1–1.7
times
compared
control
group.
1.8
control.
Erythrocyte
rose
an
average
1.3
times.
decreased
1.7
constrictions
arteries
induced
1.5
3.7
expanded
response
4.9
Thus,
over
period
three
leads
decrease
deterioration
vasomotor
