Viral Codetection and Clinical Outcomes of Infants Hospitalized With Bronchiolitis: A Multicenter Cohort Study DOI Creative Commons
Gregorio P. Milani, Andrea Ronchi, Carlo Agostoni

et al.

The Pediatric Infectious Disease Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Background: The simultaneous identification of multiple respiratory viruses is common in infants hospitalized with tract infections. Respiratory syncytial virus (RSV) one the main pathogens bronchiolitis, although codetection rhinovirus, influenza and other may occur about one-third cases. relevance viral on disease severity still controversial. This multicenter cohort study aimed to assess clinical outcomes under 24 months comparing those testing positive for RSV alone, plus another ≥2 distinct from RSV. Methods: Data were collected across 13 hospitals Lombardy, Italy, both prepandemic pandemic years. Random effect regression models also employed test association between 3 groups (infants no but than RSV) course adjusted potential confounders. Results: Among 1788 infants, 86.7% tested 6.9% 6.3% viruses. Significant differences found outcomes: non-RSV had shorter oxygen supplementation, intensive care hospital stay compared alone. Notably, was associated a higher risk radiologically confirmed pneumonia, whereas detection inversely pneumonia. Conclusions: These findings point out that milder courses alone bronchiolitis. On hand, patients are at pneumonia affected by Further research required understand underlying mechanisms optimize management strategies bronchiolitis

Language: Английский

Viral Codetection and Clinical Outcomes of Infants Hospitalized With Bronchiolitis: A Multicenter Cohort Study DOI Creative Commons
Gregorio P. Milani, Andrea Ronchi, Carlo Agostoni

et al.

The Pediatric Infectious Disease Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Background: The simultaneous identification of multiple respiratory viruses is common in infants hospitalized with tract infections. Respiratory syncytial virus (RSV) one the main pathogens bronchiolitis, although codetection rhinovirus, influenza and other may occur about one-third cases. relevance viral on disease severity still controversial. This multicenter cohort study aimed to assess clinical outcomes under 24 months comparing those testing positive for RSV alone, plus another ≥2 distinct from RSV. Methods: Data were collected across 13 hospitals Lombardy, Italy, both prepandemic pandemic years. Random effect regression models also employed test association between 3 groups (infants no but than RSV) course adjusted potential confounders. Results: Among 1788 infants, 86.7% tested 6.9% 6.3% viruses. Significant differences found outcomes: non-RSV had shorter oxygen supplementation, intensive care hospital stay compared alone. Notably, was associated a higher risk radiologically confirmed pneumonia, whereas detection inversely pneumonia. Conclusions: These findings point out that milder courses alone bronchiolitis. On hand, patients are at pneumonia affected by Further research required understand underlying mechanisms optimize management strategies bronchiolitis

Language: Английский

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