Chlamydia trachomatis upregulates lncRNA CYTOR to mediate autophagy through miR-206/MAPK1 axis DOI Creative Commons
Shan Cheng, Yi Liu,

Bei He

et al.

Pathogens and Disease, Journal Year: 2024, Volume and Issue: 82

Published: Jan. 1, 2024

Abstract Chlamydia trachomatis infection can be regulated by autophagy-related genes. LncRNA CYTOR has been proven to involved in autophagy. In this research, we investigated the role of autophagy induced C. and potential mechanisms. After infection, MAPK1 were up-regulated miR-206 was down-regulated, meanwhile, protein Beclin1 LC3-Ⅱ/LC3-Ⅰ ratio increased. Interference with or overexpression downregulated number autophagic spots LC3, decreased LC3-II/LC3-I, upregulated expression P62 protein. The luciferase reporter assay confirmed that acted as a sponge for target MAPK1. addition, promoted through MAPK1/ERK signaling pathway activation. Taken together, have identified novel molecular mechanism CYTOR/miR-206/MAPK1 axis regulation infection. This work provides an experimental basis elucidating pathogenesis treatment, prevention control related infectious diseases.

Language: Английский

Unraveling the landscape of m6A RNA methylation in wound healing and scars DOI Creative Commons
Qi Zhang, Liming Dong,

Song Gong

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Oct. 29, 2024

Abstract Wound healing is a complex process involving sequential stages of hemostasis, inflammation, proliferation, and remodeling. Multiple cell types factors, including underlying conditions like diabetes bacterial colonization, can influence outcomes scar formation. N6-methyladenosine (m6A), predominant RNA modification, plays crucial roles in gene expression regulation, impacting various biological processes diseases. m6A regulates embryonic skin morphogenesis, wound repair, pathophysiological inflammation angiogenesis. Recent studies have highlighted the role healing, formation, tissue Additionally, presents unique pattern pathological wounds scars, potentially influencing formation through modulating cellular signaling, thereby serving as potential biomarkers or therapeutic targets. Targeting modifications are strategies to enhance reduce This review aims explore mechanisms methylation discuss current challenges perspectives. Continued research this field will provide significant value for optimal repair treatment.

Language: Английский

Citations

2
N6-methyladenine RNA methylation epigenetic modification and diabetic microvascular complications DOI Creative Commons
Yuanyuan Wang,

Jiayun Zou,

Hua Zhou

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 4, 2024

N6-methyladensine (m

Language: Английский

Citations

2
Autophagy Modulation in Endothelial Hyperglycemia-Induced Wound-Healing Impairment DOI Creative Commons
Daniele Bergamaschi

Journal of Investigative Dermatology, Journal Year: 2024, Volume and Issue: 144(5), P. 929 - 930

Published: April 1, 2024

Language: Английский

Citations

0
Chlamydia trachomatis upregulates lncRNA CYTOR to mediate autophagy through miR-206/MAPK1 axis DOI Creative Commons
Shan Cheng, Yi Liu,

Bei He

et al.

Pathogens and Disease, Journal Year: 2024, Volume and Issue: 82

Published: Jan. 1, 2024

Abstract Chlamydia trachomatis infection can be regulated by autophagy-related genes. LncRNA CYTOR has been proven to involved in autophagy. In this research, we investigated the role of autophagy induced C. and potential mechanisms. After infection, MAPK1 were up-regulated miR-206 was down-regulated, meanwhile, protein Beclin1 LC3-Ⅱ/LC3-Ⅰ ratio increased. Interference with or overexpression downregulated number autophagic spots LC3, decreased LC3-II/LC3-I, upregulated expression P62 protein. The luciferase reporter assay confirmed that acted as a sponge for target MAPK1. addition, promoted through MAPK1/ERK signaling pathway activation. Taken together, have identified novel molecular mechanism CYTOR/miR-206/MAPK1 axis regulation infection. This work provides an experimental basis elucidating pathogenesis treatment, prevention control related infectious diseases.

Language: Английский

Citations

0