International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8225 - 8225
Published: July 27, 2024
A
total
hip
arthroplasty
(THA)
can
improve
quality
of
life,
but
loosening
the
prosthesis
is
a
complex
problem
in
which
vitamin
D
may
also
play
role.
The
Vitamin
Receptor
(VDR)
involved
response
cells
to
action
D,
and
its
genetic
variability
raises
question
whether
individual
differences
could
influence
risk
loosening.
aim
this
study
was
investigate
relationship
between
VDR
single
nucleotide
polymorphisms
(SNPs)
(ApaI,
BsmI,
FokI
TaqI)
serum
25(OH)D
levels
three
groups
patients:
(1)
arthroscopy
patients
after
THA
without
(CA—Control
Arthroplasty),
(2)
with
loosened
prostheses
(L—Loosening)
(3)
control
group
(C—Control).
Our
results
suggest
that
genotypes
tt
TaqI,
BB
FF
effect
protheses.
showed
ACAC
haplotype
(AtBF)
over
two
times
more
frequent
L
than
CA
+
C:
OR
=2.35
[95%
CI
1.44–3.83;
p
=
0.001].
There
no
significant
correlation
levels,
there
were
studied
groups.
Acta Biochimica et Biophysica Sinica,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
Hypertrophic
scar
(HS)
is
a
pathological
characterized
by
excessive
dermal
fibrosis.
Aberrant
m
6A
modification
patterns
have
been
identified
in
HS;
however,
the
expression
of
methyltransferase,
along
with
its
function
and
molecular
mechanisms
HS,
remains
unclear.
In
this
study,
we
find
that
both
protein
level
METTL3
m6A
methylation
are
upregulated
HS
compared
normal
skin.
To
investigate
role
knock
down
HS-derived
fibroblasts
(HSFBs)
via
shRNA.
knockdown
reduces
expressions
collagen
types
I
III
(COL
I/III)
α-SMA,
inhibits
cell
proliferation
migration,
induces
cycle
arrest
G1
phase.
MeRIP-seq
analysis
reveals
sites
on
pri-miR-31.
Our
data
indicate
pri-miR-31
elevated
METTL3-knockdown
HSFBs,
whereas
mature
miR-31-5p
reduced.
Notably,
transfection
mimic
into
HSFBs
partially
counteracts
inhibitory
effects
inhibitors
cycloleucine
STM2457
(a
specific
inhibitor
METTL3)
fibrosis
cellular
proliferation.
Additionally,
confirm
ZBTB20
downstream
target
fibroblast
Collectively,
our
findings
elucidate
epigenetic
mechanism
METTL3/m
6A/pri-miR-31/ZBTB20
fibrosis,
providing
potential
therapeutic
for
HS.
F1000Research,
Journal Year:
2025,
Volume and Issue:
14, P. 17 - 17
Published: March 24, 2025
Background
Honey,
a
natural
product
with
diverse
bioactive
compounds,
has
been
increasingly
explored
for
its
potential
anticancer
properties.
This
study
aims
to
comprehensively
analyze
the
scientific
literature
on
relationship
between
honey
and
breast
cancer.
Methods
A
bibliometric
analysis
was
conducted
using
ScienceDirect
database
identify
publications
from
2014
2024.
Data
publication
trends,
author
collaboration,
keyword
were
extracted
gain
insight
into
research
landscape.
Keyword
identified
nine
distinct
clusters,
indicating
directions
regarding
role
of
in
cancer
treatment.
Results
In
Key
journals
such
as
Journal
Ethnopharmacology
Food
Chemistry
have
at
forefront
disseminating
findings
this
domain,
demonstrating
strongly
interdisciplinary
approach
that
bridges
traditional
medicine
modern
inquiry.
The
increasing
interest
properties
honey,
evidenced
by
growing
number
studies,
underlines
promising
agent
prevention
Conclusions
provides
comprehensive
overview
current
knowledge
landscape
highlights
emerging
issues
require
further
exploration.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(7), P. 2410 - 2410
Published: April 1, 2025
Background:
Vitamin
D
plays
a
crucial
role
in
immune
system
function,
and
its
deficiency
has
been
associated
with
an
increased
risk
of
infections.
This
study
investigates
the
relationship
between
vitamin
severity
purulent
oropharyngeal
infections,
considering
need
for
surgical
interventions
duration
hospitalization.
Materials
Methods:
retrospective
included
patients
diagnosed
peritonsillar
phlegmons,
laterocervical
abscesses,
abscesses.
Patients
were
categorized
based
on
their
levels:
(<30
ng/mL)
optimal
levels
(≥30
ng/mL).
The
clinical
parameters,
length
hospitalization,
type
treatment
analyzed.
Statistical
analyses
Student's
t-test,
chi-square
test,
ANOVA
to
assess
differences
groups.
Results:
(25(OH)D3)
had
significantly
longer
hospital
stay
(8.50
days
vs.
3.24
days,
p
=
0.001)
required
more
frequent
(55.6%
27.8%,
0.002)
compared
those
levels.
A
trend
toward
complex
regimens
was
also
observed,
although
this
not
statistically
significant
(p
>
0.05).
Conclusions:
These
findings
suggest
that
may
contribute
severe
course
increasing
invasive
treatments
prolonging
highlights
importance
monitoring
potential
benefits
supplementation
preventing
managing
upper
respiratory
tract
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8632 - 8632
Published: Aug. 8, 2024
Vitamin
D
plays
a
role
in
inflammatory
skin
disease,
but
the
exact
mechanisms
and
clinical
significance
remain
unclear.
According
to
free
hormone
hypothesis,
it
is
concentration
of
25-hydroxy
vitamin
(25(OH)D)
that
biologically
active.
D-binding
protein
(DBP)
acts
as
major
transporter
circulation,
DBP
defines
25(OH)D
levels.
levels
are
elevated
various
conditions,
including
psoriasis.
Narrowband-ultraviolet
B
(NB-UVB)
most
widely
used
phototherapy
an
established
first-line
treatment
for
psoriasis
atopic
dermatitis
(AD),
often
before
proceeding
systemic
treatment.
The
aim
this
study
was
investigate
influence
NB-UVB
on
high-sensitivity
C-reactive
(hsCRP)
levels,
markers
inflammation,
disease.
Thirty
adults
(psoriasis
(n
=
20)
AD
10))
were
treated
with
NB-UVB.
Serum
DBP,
hsCRP,
total
25(OH)D,
1,25-dihydroxy
(1,25(OH)2D)
measured
after
Disease
severity
assessed
Psoriasis
Area
Severity
Index
(PASI),
SCORing
Atopic
Dermatitis
(SCORAD),
Visual
Analogue
Scale
(VAS).
decreased
patients
varied
no
clear
trend
patients.
HsCRP
both
groups,
did
not
reach
statistical
significance.
PASI,
SCORAD,
VAS
improved,
increased
Sub-analysis
indicated
better
response
deficiency
insufficiency
compared
D-sufficient
decrease
suggests
potential
anti-inflammatory
effect
phototherapy.
Measurement
may
potentially
serve
tool
identify
who
would
derive
greatest
benefit
from
