Unleashing potent antimicrobial synergy: Carnosic acid and caffeic acid tackle multidrug-resistant MRSA

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106650 - 106650

Published: April 1, 2025

Language: Английский

Phytochemical Composition and Bioactivities of Some Hydrophytes: Antioxidant, Antiparasitic, Antibacterial, and Anticancer Properties and Mechanisms

Plants, Journal Year: 2024, Volume and Issue: 13(15), P. 2148 - 2148

Published: Aug. 2, 2024

Few researches have explored the production of pharmaceuticals from aquatic plants. Therefore, this study explored, for first time, phytochemical composition and bioactivities ten Aquatic plant shoots various Nile River canals were collected, dried, ground aqueous extract preparation. Phytochemical antioxidant capacity assessed using DPPH assays. Extracts tested antiparasitic, antibacterial, anti-biofilm, anticancer activities through standard in vitro assays, measuring IC50 values, evaluating mechanisms action, including cell viability high-content screening The results showed that plants rich pharmaceutical compounds. these extracts exceeded vitamin C. promising antiparasitic activity against pathogens like Opisthorchis viverrini Plasmodium falciparum, with values between 0.7 2.5 µg/mL. They also demonstrated low MICs pathogenic bacteria, causing DNA damage, increased plasma membrane permeability, 90% biofilm inhibition. In terms activity, effective a panel cancer lines, Ludwigia stolonifera exhibiting highest efficacy. Its ranged 0.5 µg/mL pancreatic, esophageal, colon cells to 1.5 gastric cells. Overall, all below 6 µg/mL, showing significant apoptotic nuclear intensity, mitochondrial cytochrome c release, outperforming doxorubicin. This highlights potential as sources new, safe, drugs strong properties.

Language: Английский

Synthesis, kinetics, mechanisms, and bioactivity evaluations of a novel Zn(ii) complex

RSC Advances, Journal Year: 2024, Volume and Issue: 14(39), P. 28693 - 28702

Published: Jan. 1, 2024

Zn( ii )-based anticancer drugs can be suitable alternatives to conventional Pt( because of the unique chemical properties ) and low toxicity.

Language: Английский