Antimicrobial resistance of Mycobacterium avium during the COVID-19 pandemic DOI Creative Commons
I. А. Vаsilyevа,

A.E. Panova,

Valentina Tinkova

et al.

Clinical Microbiology and Antimicrobial Chemotherapy, Journal Year: 2024, Volume and Issue: 26(4), P. 462 - 469

Published: Jan. 1, 2024

Objective. Conduct a comparative assessment of the frequency and spectrum antimicrobial resistance Mycobacterium avium isolated from patients phthisiopulmonology clinic in pre-Covid period (2018–2019) during COVID-19 pandemic (2020–2023). Materials Methods. The sensitivity M. isolates was determined to 8 drugs: amikacin, clarithromycin, linezolid, moxifloxacin, ciprofloxacin, doxycycline, rifabutin, rifampicin. Drug susceptibility testing performed using serial broth microdilution method according published CLSI guidelines, M24S, 2023. Interpretation results, classifying into one three categories: sensitive, intermediate, resistant, carried out based on comparison values minimum inhibitory concentrations (MIC) drugs with breakpoint these parameters complex breakpoints were used for moxifloxacin. For rifampicin, other slow-growing non-tuberculous mycobacteria (NTM) (M. kansasii marinum) rules section 2023 “Non-species related breakpoints”. Results. A analysis (2018– 2019) (2020–2023) showed an increase proportion resistant clarithromycin (from 1.1% 20.1%, p < 0.0001), moxifloxacin 11.0% 29.2%, = 0.0007) intermediate drug 5.6% 17.6%, 0.0080) pandemic. opposite trend is noteworthy – sensitive amikacin 55.5% 79.6%, 0.0001) decrease 36% 4.4%, 0.0001). In addition, there ciprofloxacin 18.8% 9.7%, 0.0288) linezolid 27.7% 17.2%, 0.039). Conclusions. data obtained this work occurrence main reserve antimicrobials requires search new that are effective against infection caused by avium. It necessary expand MIC existing develop reasonable criterion establishing clinical categories resistance, as well revise recommendations group tested NTM determine treatment regimens.

Language: Английский

COVID-19 drugs: a critical review of physicochemical properties and removal methods in water DOI

Z.H. Chen,

Jiani Xu, Cong Li

et al.

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: 13(1), P. 115310 - 115310

Published: Jan. 5, 2025

Language: Английский

Citations

1
Highly reproducible nanofilms assembled from quaternary ammonium polymer-functionalized graphene oxide and gold nanoparticles for sensitive SERS detection of antibiotics DOI

X. X. RONG,

Shanshan Gong, Jian Wei You

et al.

Applied Surface Science, Journal Year: 2025, Volume and Issue: unknown, P. 162390 - 162390

Published: Jan. 1, 2025

Language: Английский

Citations

0
Analysis and comparison of adverse events of colistin administered by different routes based on the FAERS database DOI Creative Commons

Pengtao Xu,

L. Xu,

Hui Ji

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 26, 2025

Objective: To analyze and compare the incidence of adverse events (AEs) associated with different administration routes colistin, aim providing a reference for its safe effective clinical use. Methods: Adverse event (AE) reports related to colistin were retrieved from FDA Event Reporting System (FAERS) database. The reporting trends analyzed, Odds Ratio (ROR) Proportional (PRR) colistin-associated AEs calculated. A comparative analysis was conducted examine occurrence under colistin. Results: total 13,043 AE extracted FAERS Further 176 key indicated significant increase in number after 2021. year country showed heterogeneity across routes. Intravenous (IV) highest proportion AEs, also observed types reported inhaled oral (PO) Conclusion: Compared PO routes, IV is more likely result such as nephrotoxicity drug ineffectiveness. Additionally, there are differences

Language: Английский

Citations

0
A Review on the Prevalence and Treatment of Antibiotic Resistance Genes in Hospital Wastewater DOI Creative Commons

Lihua Lan,

Zhaoran Wang, Yuxin Chen

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 263 - 263

Published: March 31, 2025

Antibiotic resistance is a global environmental and health threat. Approximately 4.95 million deaths were associated with antibiotic in 2019, including 1.27 that directly attributable to bacterial antimicrobial resistance. Hospital wastewater one of the key sources for spread clinically relevant genes (ARGs) into environment. Understanding current situation ARGs hospital great significance. Here, we review prevalence antibiotic-resistant bacteria (ARB) from other places treatment methods used. We further discuss intersection between COVID-19 during pandemic. This highlights issues dissemination critical It imperative implement more effective processes eliminate ARGs, particularly long period.

Language: Английский

Citations

0
GO and CNT template impact on the WO3/Bi2S3 photocatalytic activity for pharmaceutical active compounds removal DOI Creative Commons
Alexandru Eneşca

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 116387 - 116387

Published: March 1, 2025

Language: Английский

Citations

0
Kinetic Patterns of Antibiotic Consumption in German Acute Care Hospitals from 2017 to 2023 DOI Creative Commons

Birgitta Schweickert,

Niklas Willrich, Marcel Feig

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 316 - 316

Published: March 18, 2025

Background: Antimicrobial consumption (AMC) patterns, besides prescribing behaviors, reflect the changing epidemiology of infectious diseases. Routine surveillance data have been used to investigate development AMC from 2017 2023 and impact COVID-19 within context framing time periods. Methods: Data 112 hospitals, continuously participating in national system hospital antimicrobial based at Robert Koch Institute, were analyzed according WHO ATC (Anatomical Therapeutic Chemical)/DDD (Defined Daily Dose) method categorized AWaRe-classification. was quantified by density (CD) expressed DDD/100 patient days (PD) admissions (AD). The period subdivided into three phases: pre-pandemic phase (2017–2019), main pandemic (2020–2021) transition (2022–2023). Linear regression models determine presence an overall trend, change intra-phasic trends phase-specific mean levels over time. Results: From total antibiotic decreased 7% 57.1 52.9 PD. Four kinetic patterns emerged across different classes: Pattern 1 displays a decreasing which slowed down throughout exhibited second-generation cephalosporins fluoroquinolones. 2 reveals rising decelerated accelerated again aminopenicillins/beta-lactamase inhibitors, beta-lactamase sensitive pencillins, azithromycin first-generation cephalosporins. 3 shows elevated carbapenems, glycopeptides, linezolid third-generation 4 trend phase, reversed without achieving resistant penicillins, daptomycin, fosfomycin (parenteral) ceftazidime/avibactam. Conclusions: Kinetic classes might COVID-19-related effects associated changes co-circulating pathogens health care supply. Broad-spectrum antibiotics with persisting require special attention focused stewardship activities.

Language: Английский

Citations

0
Impact of COVID-19 pandemic on the implementation of transmission-based precautions DOI

K. L. Yap,

Kyaw Zaw Linn,

Allie Yin Lim

et al.

Journal of Hospital Infection, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
The Impact of the COVID-19 Pandemic on Pediatric Microbial Resistance Patterns and Abandonment Rates in Western Romania—An Interdisciplinary Study DOI Creative Commons
Dan Dumitru Vulcănescu, Iulia Cristina Bagiu,

Tiberiu Liviu Dragomir

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(4), P. 411 - 411

Published: April 16, 2025

Background: The COVID-19 pandemic in Romania exacerbated pediatric antimicrobial resistance (AMR). Overuse of broad-spectrum antibiotics may be related to increased multidrug-resistant bacteria. main aim this study was assess AMR trends and phenotypes, while a secondary objective investigate the potential links with hospital abandonment. Methods: This retrospective from Children’s Emergency Hospital “Louis Țurcanu”, Timișoara, focused on patterns 2019 pre-pandemic, 2021 pandemic, 2023 post-pandemic. following phenotypes were assessed: MRSA, MRCoNS, VRE, ESBL, CRO, MDR, XDR, PDR. Results: There 3530 total patients 6885 samples. 69.92% samples resistant at least one class, (72.69% 2019, 67.05% 2021, 69.16% 2023). Specifically, towards penicillins remained high across entire period (57.45–60.93%), classes presented elevated pandemic: cephalosporins (42.91%), combination therapies (40.95%), reserve (38.89%), cyclines (13.83%). As for MRSA MRCoNS peaked during (36.08% 81.43%, respectively) VRE relatively constant. Overall ESBL declined 14.45%, overall CRO (8.81%). MDR fell (64.47%), XDR (9.87%). No PDR cases observed. Pediatric abandonment an increasing concern, regional rising 5.42% (2019) 9.83% (2023). Compared general population, abandoned observed fluoroquinolones (50.00%), Aminogycolsides (60.00%), (70.00%), urinary (60.00%). Resistance (OR = 5.17, p 0.0304) 5.64, 0.0049) key predictors risk. Conclusions: influenced trends, notable peaks CRO. Post-pandemic suggest continued escalation resistance. association between infections highlights need robust stewardship social intervention policies.

Language: Английский

Citations

0
An umbrella systematic review of antibiotics therapy in COVID-19 patients: implications for antimicrobial resistance DOI Open Access
Omar Irfan, Aqsa Amjad,

Muskaan Abdul Qadir

et al.

International Journal of Community Medicine and Public Health, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Evidence from public health bodies describes extensive overuse of antibiotics during the COVID-19 pandemic worldwide, further worsening spread antimicrobial resistance (AMR). Umbrella review (CRD42024590181) SRs that investigated safety and efficacy antibiotic drug therapies for treatment in patients irrespective disease severity age was conducted. Comprehensive searches were conducted between July 30, 2024, October 26, covering PubMed Cochrane databases, other sources, such as, Coronavirus (COVID-19) resources, Google Scholar. The AMSTAR2 tool used to assess methodological quality included SRs. Review findings synthesized narratively. systematic search yielded a total 3624 records electronic databases search. Ten original SRs, with 1-42 studies each SR, finally included. Sample size per SR ranged 665-37,429 patients. Azithromycin most commonly administered therapy. Overall, this reported no difference all-cause mortality, time clinical recovery, length hospital stay, progression severe disease, viral clearance, rate co-infections or superinfections, adverse events among treated compared placebo/standard care. suggests use is not associated better outcomes. Further assessing prevalence AMR usage infection could aid improving stewardship practice.

Language: Английский

Citations

0
Phytochemical Composition, In Silico Molecular Docking Analysis and Antibacterial Activity of Lawsonia inermis Linn Leaves Extracts against Extended Spectrum Beta-Lactamases-Producing Strains of Klebsiella pneumoniae DOI Creative Commons
Adam Mustapha, Ahmed Nouri Alsharksi, Ukpai A. Eze

et al.

BioMed, Journal Year: 2024, Volume and Issue: 4(3), P. 277 - 292

Published: Aug. 26, 2024

Klebsiella pneumoniae is an opportunistic Gram-negative bacterium in the Enterobacteriaceae family associated with a wide range of diseases, such as pneumonia, bloodstream infections, meningitis and urinary tract infections. Infections caused by drug-resistant strains pose significant threat to effectiveness conventional antibiotics. Hence, this has led need explore alternative antimicrobial therapies, especially natural products derived from plant sources. This study assessed phytochemical composition antibacterial properties performed molecular docking analysis Henna leaves (Lawsonia inermis L.) extracts on pneumoniae. Crude ethanol methanol L. were prepared at different concentrations (25, 50, 75 100 mg/mL) tested extended spectrum beta-lactamases (ESBLs)-producing Phytocompounds identified using gas chromatography–mass spectrometry (GC-MS) further subjected virtual ligands screening DataWarrior (v05.02.01) AutoDock4.2 (v4.2.6). The active compounds determined analysis, including phytochemical, physicochemical, pharmacokinetics score. GC-MS 27 phytoconstituents, ethyl acetate, sclareol, 2-[1,2-dihydroxyethyl]-9-[β-d-ribofuranosyl] hypoxanthine, α-bisabolol 2-Isopropyl-5-methylcyclohexyl 3-(1-(4-chlorophenyl)-3-oxobutyl)-coumarin-4-yl carbonate. then screened for their physicochemical pharmacokinetic properties. results revealed that mg/mL showed significantly higher (p < 0.05) zones inhibition (13.7 ± 1.2 mm), while 50 lower (6.3 0.6 mm) compared all other treatments. out identified, only twelve (12) have drug-likeness activity. 12 determine binding energies CTX-M protein Only one compound [CID_440869; (2-[1,2-dihydroxyethyl]-9-[β-d-ribofuranosyl] hypoxanthine)] had best energy −9.76 kcal/mol; hence, it can be considered potentially suitable treatment infections ESBLs-producing demonstrated effects. Further research could potential applications many bacterial strains.

Language: Английский

Citations

2