Organotin(IV)-tetraphenylethylene acylhydrazone compounds with aggregation-induced emission property and application in anticancer therapy

Dyes and Pigments, Journal Year: 2024, Volume and Issue: 223, P. 111963 - 111963

Published: Jan. 21, 2024

Language: Английский

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Antituberculosis, antimicrobial, antioxidant, cytotoxicity and anti-inflammatory activity of Schiff base derived from 2,3-diaminophenazine moiety and its metal(II) complexes: structural elucidation, computational aspects, and biological evaluation

Reviews in Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract Enticed by the present scenario of infectious diseases, four new Co(II), Ni(II), Cu(II), and Cd(II) complexes Schiff base ligand were synthesized from 6,6′-((1E-1′E)(phenazine-2,3-dielbis(azanylidene)-bis-(methanylidene)-bis-(3-(diethylamino)phenol)) ( H 2 L ) to ascertain as effective drug for antituberculosis, anti-inflammatory, antioxidant, cytotoxic antimicrobial activities. The organic its metal(II) characterized numerous physical spectroscopic methods, which showed that have a general formula, [ ML ], (where M = Co(II) C1 ), Ni(II) C2 Cu(II) C3 C4 )), metal been proposed square planar geometry, are amorphous in nature, thermally stable. Data highlight obtained activity testing against tuberculosis, inflammation, oxidants all compounds significantly active these symptoms. Also, was evaluate effectiveness various bacterial fungal strains. Specifically, strains Bacillus subtilis , Staphylococcus aureus Escherichia coli Pseudomonas aeruginosa two Aspergillus flavus Candida albicans tested compared results some standard drugs. revealed compound more than comparison In addition, found be most antibiotics fungi, while other moderate antifungal activity. Moreover, support vitro results, certain computational studies molecular docking studies, DFT, MESP, AMEDT also conducted confirm an tuberculosis. These is tuberculosis has desirable effects such absorption, no degradation hepatotoxicity, etc.

Language: Английский

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Organotin(IV) from Simple Complexes to Macromolecules: A Review Inspired by the Late Professor Charles Carraher

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: 34(7), P. 2855 - 2892

Published: June 19, 2024

Language: Английский

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Synthesis, crystal structure, and anticancer activity of organotin(IV) complexes based on chlorine substituted aryl ligands

Medicinal Chemistry Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Language: Английский

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The crystal structure of N′,N″-[1,2-bis(4-chlorophenyl)ethane-1,2-diylidene]bis(furan-2- carbohydrazide), C₂₄H₁₆Cl₂N₄O₄

Zeitschrift für Kristallographie - New Crystal Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract C 24 H 16 Cl 2 N 4 O , monoclinic, P 1 / n (no. 14), a = 10.2264(4) Å, b 16.1772(6) c 13.8429(6) β 102.463(5)°, V 2236.13(16) Å 3 Z 4, R gt ( F ) 0.0574, wR ref 0.1588, T 220(2) K.

Language: Английский

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Organotin(IV) complexes: Emerging Frontiers in anticancer therapeutics and bioimaging applications

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216582 - 216582

Published: March 13, 2025

Language: Английский

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Design, synthesis and mechanistic studies of novel arylformylhydrazone butylphenyltin complexes as potential anticancer agents

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 149, P. 107502 - 107502

Published: May 26, 2024

Language: Английский

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Design, synthesis, crystal structure and anticancer activity of organotin(IV)-rhein carboxylates

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1318, P. 139341 - 139341

Published: July 20, 2024

Language: Английский

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Studies of Anticancer Activities In Vitro and In Vivo for Butyltin(IV)–Iridium(III) Imidazole–Phenanthroline Complexes with Aggregation-Induced Emission Properties

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(31), P. 14641 - 14655

Published: July 25, 2024

Organotin(IV) and iridium(III) complexes have shown good application potential in the field of anticancer; however, aggregation-caused quenching (ACQ) effect induced by high concentration or dose has limited research on their targeting anticancer mechanism. Then, a series aggregation-induced emission (AIE)-activated butyltin(IV)–iridium(III) imidazole-phenanthroline were prepared this study. Complexes exhibited significant fluorescence improvement aggregated state because restricted intramolecular rotation (RIR), accompanied an absolute quantum yield up to 29.2% (IrSn9). demonstrated vitro antiproliferative antimigration activity against A549 cells, following lysosomal–mitochondrial apoptotic pathway. Nude mouse models further confirmed that had favorable vivo antitumor comparison cisplatin. Therefore, possess as substitutes for platinum-based drugs.

Language: Английский

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Synthesis, crystal structure and antitumor activity of trialkyltin (IV) 9,10-anthraquinone-2-carboxylate

Journal of Organometallic Chemistry, Journal Year: 2023, Volume and Issue: 1006, P. 122997 - 122997

Published: Dec. 20, 2023

Language: Английский

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