Insights into the antineoplastic activity and mechanisms of action of coumarin-coordinated 8-hydroxyquinoline ruthenium(II/III) compounds DOI

Ling-Qi Du,

Yan Yang, Li Ruan

et al.

Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 259, P. 112659 - 112659

Published: July 4, 2024

Language: Английский

Coordination complexes of Bipyridines (CCBs): Chemistry, bonding and applications DOI
Chandrabhan Verma, Ibrahim Y. Yaagoob,

Lipiar K.M.O. Goni

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 529, P. 216433 - 216433

Published: Jan. 13, 2025

Language: Английский

Citations

3
Preparation, characterization, single-crystal analysis, and cytotoxic assessment of complexes formed by Schiff base and 8-hydroxyquinoline co-ligand with Co(II), Ni(II), and Mn(II) metal ions DOI
Ahmet Oral Sarıoğlu,

Bahar Sürmelihindi,

Hatice Gamze Soğukömeroğulları

et al.

Polyhedron, Journal Year: 2024, Volume and Issue: 261, P. 117129 - 117129

Published: July 7, 2024

Language: Английский

Citations

4
Silver(I) complexes containing bioactive salicylic acid derivatives: Synthesis, characterization, antibacterial activity, and their underlying mechanism DOI
Chongyang Wu, Yuanyuan Shan, Jia Luo

et al.

Journal of Inorganic Biochemistry, Journal Year: 2025, Volume and Issue: 266, P. 112845 - 112845

Published: Feb. 4, 2025

Language: Английский

Citations

0
YTHDF1-mediated m6A modification promotes cisplatin resistance in ovarian cancer via the FZD7/Wnt/β-catenin pathway DOI

Jintian Miao,

Xinyan Jiang,

Siyun Wang

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

0
RECENT ADVANCES IN THE DISCOVERY OF COPPER(II) COMPLEXES AS POTENTIAL ANTICANCER DRUGS DOI Creative Commons
Bartłomiej Rogalewicz, Agnieszka Czylkowska

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 292, P. 117702 - 117702

Published: April 29, 2025

This review article offers a literature search of the most active, new copper (II) anticancer complexes based on nitrogen-containing ligands, reported in over past 5 years: from beginning 2019, until mid-2024. In modern world, cancer remains one deadliest diseases all. Although years ongoing research allowed us to better understand its nature, and thus aim more precisely at specific molecular targets pathways, many aspects remain unclear. Today, chemotherapy still forefront treatment. With ever-growing struggles overcome chemoresistance occurrence serious side effects, discovery new, selective active drugs is task an utmost importance. At same time, (II)-based compounds offer wide array biological activities valuable biochemical properties. provides update recent advances potential among five years.

Language: Английский

Citations

0
Innovative Approaches in the Synthesis and Optimization of Copper Complexes for Antitumor Therapies: A Comprehensive Review DOI Creative Commons
Clara Maria Faria Silva, Ricardo Campos Lino,

Mariana Cristina Teixeira de Moura

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(10), P. 2104 - 2104

Published: May 9, 2025

Cancer is the second leading cause of death worldwide. Late diagnosis, low drug selectivity, high toxicity, and treatment resistance are challenges associated with pharmacological interventions. The commonly used therapies include surgery, radiotherapy, hormonal therapy, immunotherapy, chemotherapy. Recently, Cu complexes have been studied owing to their biological functions effects on tumor angiogenesis. In this review, we examined 23 types cancer revealed use cell lines. synthesis ligands such as phenanthroline thiosemicarbazones has also reported. Such co-ligation promising because its cytotoxicity selectivity. Compared cisplatin, complexes, especially mixed showed better interactions DNA, generating reactive oxygen species inducing apoptosis. Nanoformulations adopted improve activity compounds. They enhance efficacy by targeting them tissue, thereby improving safety. Studies explored clinically relevant pharmacophores, suggesting a “hybrid chemotherapy” against resistant tumors. Overall, demonstrated therapeutic versatility, antitumor efficacy, reduced adverse effects, showing great potential alternatives conventional chemotherapy justifying future clinical investigations validate use.

Language: Английский

Citations

0
Anticancer mechanisms of β‐carbolines DOI
Shivam Mishra, Aditi Gupta, Shweta Jain

et al.

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 103(4)

Published: April 1, 2024

Abstract β‐Carboline nucleus is therapeutically valuable in medicinal chemistry for the treatment of varied number diseases, most importantly cancer. The potent and wide‐ranging activity β‐carboline has established them as imperative pharmacological scaffolds especially cancer treatment. Numerous derivatives such Tetrahydro β‐carbolines, metal complexed mono, di tri substituted β‐carbolines have been reported to possess dynamic anticancer activity. These different had shown mechanism action plays important role drug discovery development. review an update both synthetic natural origin acting through various targets against cancerous cells. In addition this, studies multitarget molecules designed by coupling along with other mechanisms neoplasm are also summarized.

Language: Английский

Citations

2
Anticancer activity of 8-hydroxyquinoline-triphenylphosphine rhodium(III) complexes targeting mitophagy pathways DOI
Xiaoqiong Huang,

Run-Chun Wu,

Jianmin Liang

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 272, P. 116478 - 116478

Published: May 4, 2024

Language: Английский

Citations

2
Four new ruthenium(II) coordination compounds bearing coumarin derivatives as anticancer agents DOI
Qi‐Pin Qin,

Xiaofeng Zhou,

Ling-Qi Du

et al.

Polyhedron, Journal Year: 2024, Volume and Issue: 263, P. 117192 - 117192

Published: Aug. 22, 2024

Language: Английский

Citations

1
Insights into the antineoplastic activity and mechanisms of action of coumarin-coordinated 8-hydroxyquinoline ruthenium(II/III) compounds DOI

Ling-Qi Du,

Yan Yang, Li Ruan

et al.

Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 259, P. 112659 - 112659

Published: July 4, 2024

Language: Английский

Citations

1