Metal-antimicrobial peptides combo: promising weapons to combat bacteria invaders DOI Creative Commons
Lucia Falcigno, Simone Braccia, Rosa Bellavita

et al.

Frontiers in Drug Discovery, Journal Year: 2024, Volume and Issue: 4

Published: Oct. 16, 2024

Antimicrobial resistance has significantly increased over the last 30 years, prompting scientists to continuously look for novel, effective ways combat drug-resistant bacteria and fungi. Due their broad range of effectiveness, ease synthesis, ability avoid resistance, antimicrobial peptides (AMPs) represent a potential approach. The direct investigation metal effects on peptide activity not received much attention. Divalent ions such as Zn(II), Cu(II), Ni(II), Fe(II) do, in fact, influence some AMPs, producing an effect mode action or function. Although precise process by which metals are involved microbial death is well understood, this review goes into detail several strategies enhance AMPs through synergy with metals. Important variables these interactions include individual sequence, type ion, capacity form chelates, softness ligand/metal complex. This article offers thorough summary alter structure boost sequester impact

Language: Английский

Investigation of Antimicrobial, Antioxidant, and Anticancer Properties of Substituted Phenethylamine-Based Imine and Metal Complexes DOI Creative Commons
Taha Yasin Bayram, Merve Yildirim, Elif Aksakal

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Abstract Imine is a bioactive molecule formed by the reaction of primary amine with aldehyde or ketone. Imines can form stable complexes metals due to C = N group in their structures. These have antibacterial, antifungal, anticancer, and antioxidant properties. Based on literature data, this study synthesized substituted phenethylamine-based imine compounds copper (Cu) zinc (Zn) metal complexes. The imine-metal complexes' antimicrobial, activities were evaluated. antimicrobial activity was tested against pathogens using disk diffusion method. No observed for anticancer investigated lung cancer cell line (A549) healthy dermal fibroblast (HDF) WST-8 SRB assay methods. results revealed dose-dependent A549 line, IC50 values ​​ranging from 43.65 99.36 µg/mL. Additionally, cytotoxic effects HDF cells. responses free radicals oxidative stress evaluated ABTS CUPRAC However, no detected these analyses, it predicted that may be potential candidates as agents.

Language: Английский

Citations

0
Modulating Copper(II) Coordination and Antimicrobial Activity: Effects of d-Amino Acid Substitution and Retro-Inverso Modification in Human Saliva MUC7 Peptide DOI Creative Commons
Joanna Wątły,

Klaudia Szarszoń,

Monika Sabieraj

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Fragments of MUC7, a salivary protein involved in nonimmune defense, arise from proteolytic cleavage saliva and exhibit antimicrobial properties. However, their therapeutic use is limited by low stability due to further degradation. To address this, native MUC7 fragment was modified using d-amino acids the retro-inverso strategy. Given role metal ions enhancing peptides, we analyzed bioinorganic chemistry these systems with Cu(II) assessed activity against fungal bacterial strains. This study first explore correlation between binding mode, structure, stability, peptides as well coordination such systems. A combination experimental techniques (potentiometry, mass spectrometry, UV–vis, circular dichroism, electron paramagnetic resonance, nuclear magnetic resonance spectroscopy) density functional theory calculations characterized chemistry. Our results demonstrate that "standard" enantiomeric exchange modifications have minimal effect on secondary structure biological studied complexes. significantly influence thermodynamic

Language: Английский

Citations

0
Antibacterial activity and underlying mechanism of action of paeonol against Sclerotium rolfsii DOI

Chunlan Shi,

Hongmei Li, Dewei Yang

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2025, Volume and Issue: unknown, P. 106436 - 106436

Published: May 1, 2025

Language: Английский

Citations

0
Bioinorganic Chemistry Meets Microbiology: Copper(II) and Zinc(II) Complexes Doing the Cha-Cha with the C-t-CCL-28 Peptide, Dancing till the End of Microbes DOI Creative Commons

Klaudia Szarszoń,

Natalia Baran,

Paulina Śliwka

et al.

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

The necessity to move away from conventional antibiotic therapy has sparked interest in antimicrobial peptides (AMPs). One fascinating example is human CCL-28 chemokine produced by acinar epithelial cells the salivary glands. It can also be released into oral cavity with saliva, playing a crucial role protection. C-terminal domain of possesses antifungal and antibacterial properties, which are likely linked membrane disruption enzyme leakage. Studies suggest that AMPs become more potent after they have bound Cu(II) or Zn(II). In many cases, these ions essential for maximizing effectiveness altering peptides' physicochemical such as their local charge structure. examined peptide binds Zn(II) very effectively, forming equimolar complexes. Metal ion binding affinity, coordination mode, activity strongly depend on pH environment. Coordination modes been proposed based results potentiometric titrations, spectroscopic studies (UV-visible, electron paramagnetic resonance circular dichroism at different path lengths), mass spectrometry. properties complexes fragment assessed against fungal bacterial strains, demonstrating exceptional

Language: Английский

Citations

1
Metal-antimicrobial peptides combo: promising weapons to combat bacteria invaders DOI Creative Commons
Lucia Falcigno, Simone Braccia, Rosa Bellavita

et al.

Frontiers in Drug Discovery, Journal Year: 2024, Volume and Issue: 4

Published: Oct. 16, 2024

Antimicrobial resistance has significantly increased over the last 30 years, prompting scientists to continuously look for novel, effective ways combat drug-resistant bacteria and fungi. Due their broad range of effectiveness, ease synthesis, ability avoid resistance, antimicrobial peptides (AMPs) represent a potential approach. The direct investigation metal effects on peptide activity not received much attention. Divalent ions such as Zn(II), Cu(II), Ni(II), Fe(II) do, in fact, influence some AMPs, producing an effect mode action or function. Although precise process by which metals are involved microbial death is well understood, this review goes into detail several strategies enhance AMPs through synergy with metals. Important variables these interactions include individual sequence, type ion, capacity form chelates, softness ligand/metal complex. This article offers thorough summary alter structure boost sequester impact

Language: Английский

Citations

1