Copper complexes induce haem oxygenase-1 (HMOX1) and cause apoptotic cell death in pancreatic cancer cells DOI Creative Commons

Zakeeya Jhetam,

Carla Martins-Furness,

Cathy Slabber

et al.

Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 264, P. 112815 - 112815

Published: Dec. 19, 2024

Language: Английский

Designing an anticancer Pd(II) complex as poly(ADP-ribose) polymerase 1 inhibitor DOI

Shuangshuang Gai,

Peng Cao,

Xuwei Zhong

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 297, P. 139885 - 139885

Published: Jan. 14, 2025

Language: Английский

Citations

1
Lactoferrin Nanoparticle-Vanadium Complex: A Promising High-Efficiency Agent against Glioblastoma by Triggering Autophagy and Ferroptosis DOI

Shuangshuang Gai,

Qiwei Yan,

Shan Li

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Glioblastoma represents the most aggressive type of brain cancer with minimal clinical advancements in recent decades attributed to absence efficient drug delivery strategies. In this study, we synthesized a series vanadium complexes (V1-V4) and then constructed lactoferrin (LF)-V4 nanoparticle (NP) system. The nanoplatform crossed blood-brain barrier by binding low-density lipoprotein receptor-associated protein-1 selectively targeted glioblastoma, ultimately inhibiting growth situ glioblastoma tumors. LF-V4 NPs induced autophagic cell death U87-MG cells generating reactive oxygen species (ROS) that damaged mitochondria. Further studies revealed triggered lipid peroxidation through accumulation ROS, depletion GSH, downregulation GPX4 SLC7A11, leading ferroptosis cells.

Language: Английский

Citations

1
Recent development of Schiff-base metal complexes as therapeutic agents for lung cancer DOI
Ming Jiang, Xiaoling Su,

Xuwei Zhong

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1318, P. 139403 - 139403

Published: July 22, 2024

Language: Английский

Citations

8
Development a stannum(IV) 8-quinolinecarbaldehyde thiosemicarbazone complex with remarkable anticancer activity via pyroptosis and apoptosis DOI
Xiaoling Wu, Jinhui Pang, Wenjuan Li

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142225 - 142225

Published: March 1, 2025

Language: Английский

Citations

0
RECENT ADVANCES IN THE DISCOVERY OF COPPER(II) COMPLEXES AS POTENTIAL ANTICANCER DRUGS DOI Creative Commons
Bartłomiej Rogalewicz, Agnieszka Czylkowska

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117702 - 117702

Published: April 1, 2025

Language: Английский

Citations

0
In vitro and In vivo anticancer activities of Bi(III) 2-thiazolecarboxaldehyde thiosemicarbazone complex DOI

Xiaoying Jia,

Jinhui Pang,

Yong Kyu Chu

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1318, P. 139389 - 139389

Published: July 23, 2024

Language: Английский

Citations

3
Recent advances of Schiff base metal complexes as potential anticancer agents DOI
Lin Lv, Tianpeng Zheng,

Lu Tang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 525, P. 216327 - 216327

Published: Nov. 20, 2024

Language: Английский

Citations

2
New metal complexes of 1H-benzimidazole-2-yl hydrazones: cytostatic, proapoptotic and modulatory activity on kinase signaling pathways DOI Creative Commons
Maria Argirova, Emiliya Cherneva, Rositsa Mihaylova

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 764, P. 110245 - 110245

Published: Nov. 29, 2024

Language: Английский

Citations

0
Synthesis, Crystal Structure, Formation Mechanism, Theoretical Studies, and Biological Evaluation of Azine‐Based Bismuth (III) Complex DOI Open Access

Fei‐Hong Yao,

Chen‐Xuan Tang,

X. Fan

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 39(1)

Published: Dec. 10, 2024

ABSTRACT The azine‐based bismuth (III) complex [Bi(H 2 L 1 )(NO 3 ) (H O) ]•H O( 1a was synthesized by an equivalent reaction between Schiff base and Bi (NO •5H O using mannitol as auxiliary agent. During the formation of ( ), containing 3‐methoxy group transformed into 3‐methoxysalicylaldehyde azine further coordinated with III ion to form a mononuclear ). Bismuth ions were unexpectedly found catalyze azines from bases derived pyrazinohydrazide, their mechanism studied. Theoretical studies involving thermodynamic electronic properties done density functional theory (DFT) B3LYP method. Furthermore, in vitro biological evaluation showed that antimicrobial cytotoxic activities much higher than those free ligands. obtained MIC IC 50 values almost close reference drugs.

Language: Английский

Citations

0
Copper complexes induce haem oxygenase-1 (HMOX1) and cause apoptotic cell death in pancreatic cancer cells DOI Creative Commons

Zakeeya Jhetam,

Carla Martins-Furness,

Cathy Slabber

et al.

Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 264, P. 112815 - 112815

Published: Dec. 19, 2024

Language: Английский

Citations

0