The Amyloid Beta Aggregation Inhibition Properties of New Pt (II) Complexes and Their Potential in Alzheimer's Treatment

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(5)

Published: April 10, 2025

ABSTRACT In this study, N‐phenylortho‐phenylenediamine and N‐phenyl ethylenediamine were utilized as amines, two novel ligands, benzimidazole (LI) Schiff base (LII), synthesized through condensation reactions with 3‐methoxy‐4‐benzyloxybenzaldehyde. Furthermore, using these same LIII (benzimidazole) 3‐phenoxybenzaldehyde LIV (Schiff base) 4‐benzyloxybenzaldehyde in accordance the literature. Then, Pt (II) complexes (Ia, Ib, II, III, IV) prepared it was determined that Ia Ib are geometric isomers. The ligands characterized 1 H‐NMR, 13 C‐NMR, FT‐IR, elemental analysis methods. cytotoxic effects of evaluated on SH‐SY5Y neuronal cells. Low‐toxicity Ia, IV then tested for their ability to inhibit amyloid beta (Aβ 1–42 ) aggregation. Thioflavin T fluorescence analysis, AFM imaging, MALDI‐TOF mass spectrometry demonstrated complexes, particularly at a 1:1 complex‐to‐amyloid molar ratio, effectively inhibited Aβ These findings suggest containing may be effective against Alzheimer's disease by alleviating toxicity.

Language: Английский

Impedimetric Detection of Amyloid Beta (1–42) on Curcumin‐Copper Complex Electropolymerized Graphite Electrode

Electroanalysis, Journal Year: 2025, Volume and Issue: 37(5)

Published: May 1, 2025

In the study, curcumin (Cur) electropolymerization on surface of disposable pencil graphite electrode (PGE) was carried out using cyclic voltammetry (CV) technique. The interaction electropolymerized PGE with aluminum (Al), nickel (Ni), and copper (Cu) metals investigated differential pulse (DPV) It observed that highest between curcumin–metal complexes occurred in presence Cu (II). Electrochemical characterization poly (Cur)‐Cu (II)/PGE by electrochemical impedance spectroscopy (EIS) CV measurements. detection (II) different concentration ratios EIS A β (1–42) peptide is known to play a significant role pathogenesis Alzheimer's disease (AD). immobilization at temperatures its various optimized accordingly, impedimetric results were recorded. limit for analysis calculated over linear range 1–20 µM found be 0.99 µM. onto performed (Cur)/PGE, (II)/PGE, as well PGE. According these results, obtained (II)/PGE. biointeraction curcumin‐Cu complex offers promising opportunities development approaches potential drugs diagnosis AD. determination curcumin‐Cu(II) based method holds promise new molecules treatment

Language: Английский