COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss

Human Reproduction Update, Journal Year: 2023, Volume and Issue: 30(2), P. 133 - 152

Published: Nov. 28, 2023

Abstract BACKGROUND Pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to experience preterm birth and their neonates be stillborn or admitted a neonatal unit. The World Health Organization declared in May 2023 an end the disease 2019 (COVID-19) pandemic as global health emergency. However, pregnant still becoming SARS-CoV-2 there is limited information available regarding effect of infection early pregnancy on outcomes. OBJECTIVE AND RATIONALE We conducted this systematic review determine prevalence loss SARS-Cov-2 compare risk without infection. SEARCH METHODS Our based prospectively registered protocol. search PregCov19 consortium was supplemented extra electronic specifically up 10 March PubMed, Google Scholar, LitCovid. included retrospective prospective studies infection, provided that they contained losses first and/or second trimester. Primary outcome miscarriage defined before 20 weeks gestation, however, reported 22 24 were also included. Additionally, we report occur at trimester specifying gestational age, for only when study presented stillbirths foetal separately from miscarriages. Data stratified into Secondary outcomes ectopic (any extra-uterine pregnancy), termination pregnancy. At least three researchers independently extracted data assessed quality. calculated odds ratios (OR) differences (RDs) corresponding 95% CI pooled using random effects meta-analysis. To estimate prevalence, performed meta-analysis proportions. Heterogeneity by I2. OUTCOMES 120 comprising total 168 444 infection; which 18 233 Evidence level considered low moderate certainty, mostly owing selection bias. did not find evidence association between (OR 1.10, 0.81–1.48; I2 = 0.0%; RD 0.0012, −0.0103 0.0127; 0%; 9 studies, 4439 women). Miscarriage occurred 9.9% (95% 6.2–14.0%; 68%; 46 1797 women) SARS CoV-2 1.2% 0.3–2.4%; 34%; 33 studies; 3159 proportion pregnancies 1.4% 0.02–4.2%; 66%; 14 950 Termination 0.6% 0.01–1.6%; 79%; 39 1166 WIDER IMPLICATIONS found no indication increases provide better estimates, well-designed needed include conception consider clinical manifestation severity loss, well potential confounding factors such previous loss. For practice, should advised take precautions avoid exposure receive vaccination.

Language: Английский

COVID-19 Pandemic Impact on the Maternal Mortality in Kazakhstan and Comparison with the Countries in Central Asia

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(3), P. 2184 - 2184

Published: Jan. 25, 2023

Maternal mortality ratio is one of the sensitive indicators that can characterize performance healthcare systems. In our study we aimed to compare maternal in Central Asia region from 2000 2020, determine its trends and evaluate association between countries’ total health expenditures. We also compared causes before during pandemic Kazakhstan. The data were derived public statistical collections each Asian country. During pre-pandemic period, nations had a downward trend mortality. countries decreased by 38% 47.3 per 100,000 live births 29.5 2020. Except for Uzbekistan, where this indicator decreased, all experienced sharp increase proportion indirect deaths Kazakhstan reached 76.3% There an their expenditures expressed national currency units (r max = −0.89 min −0.66, p < 0.01). revealed issue availability accessibility research region. findings suggest there must be additional efforts local authorities enhance preparedness systems new challenges improve accessibility.

Language: Английский

Gestational weight gain during pregnancy is the risk factor for Omicron infection: a retrospective case–control study

BMC Pregnancy and Childbirth, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 18, 2024

It remains unclear whether gestational weight gain (GWG) during pregnancy is associated with Omicron infection in pregnant women. To investigate an increased risk of infection. This a retrospective case-control study women from The Third Affiliated Hospital Sun Yat-sen University December 1 to 31, 2022. Pregnant infected were compared those uninfected using chi-square statistics for categorical variables and t-tests or ANOVA continuous variables. Multivariable logistic regression, along subgroup analyses, was used the association between Our included 369 who met eligibility criteria. proportion term, 113(30.6%) 256(69.4%). Classified according GWG pregnancy, above IOM significantly (P = 0.006). After adjusting demographic factors complications, this particularly notable (OR 2.55, 95%CI 1.35-4.85, P 0.004). pregestational BMI, normal-weight women, 0.01). 2.56, 1.24-5.31, Among normal weight, independent factor

Language: Английский