Rapid diagnosis and severity scale of post-COVID condition using advanced spectroscopy DOI Creative Commons

Paula Antelo-Riveiro,

Manuel Vázquez‐Carrera,

María Jesús Domínguez-Santalla

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 328, P. 125474 - 125474

Published: Nov. 24, 2024

The COVID-19 pandemic has resulted in a persistent health challenge known as Post-COVID Condition (PCC), characterized by symptoms lasting at least three months after the initial SARS-CoV-2 infection and potentially persisting for several years. While studies on PCC using lipidomics proteomics have been conducted, these methods are costly time-consuming. comprehensive analysis of UV-VIS-NIR-MIR spectroscopy is explored here an alternative rapid cheap diagnosis quantification severity PCC. Blood samples from 65 patients, previously analyzed lipidomic proteomic studies, along with new were examined to develop model that quantifies based solely spectrophotometric data. Significant spectral variability was observed UV-VIS region, particularly between 297 600 nm, correlating strongly patient symptoms. Unsupervised clustering algorithms this region effectively differentiated asymptomatic symptomatic achieving Jaccard similarity score 0.667 when compared clinical symptom classifications. Comparative indicated captures clinically relevant biochemical information. results developed work quantify demonstrated robustness data, underscoring method's potential rapid, non-invasive, cost-effective diagnostic tool. This study highlights strengths spectroscopic techniques, suggesting their suitability widespread application diagnosing monitoring PCC, emphasizes need further refinement integration into healthcare practice, implementation portable devices.

Language: Английский

Utility of Protein Markers in COVID-19 Patients DOI Open Access
Alicia López-Biedma, María Ángeles Onieva-García, Desirée Martín‐García

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 653 - 653

Published: Jan. 14, 2025

COVID-19 has been a challenge at the healthcare level not only in early stages of pandemic, but also subsequent appearance long-term COVID-19. Several investigations have attempted to identify proteomic biomarkers an attempt improve clinical care, guide treatment and predict possible patient outcomes. Proteins such as C-reactive protein (CRP) or interleukin 6 (IL-6) are clear markers severe disease, many others proposed that could help risk stratification prediction specific complications. This review aims bring together most relevant studies this regard, providing information notable relation found date.

Language: Английский

Citations

0
Rapid diagnosis and severity scale of post-COVID condition using advanced spectroscopy DOI Creative Commons

Paula Antelo-Riveiro,

Manuel Vázquez‐Carrera,

María Jesús Domínguez-Santalla

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 328, P. 125474 - 125474

Published: Nov. 24, 2024

The COVID-19 pandemic has resulted in a persistent health challenge known as Post-COVID Condition (PCC), characterized by symptoms lasting at least three months after the initial SARS-CoV-2 infection and potentially persisting for several years. While studies on PCC using lipidomics proteomics have been conducted, these methods are costly time-consuming. comprehensive analysis of UV-VIS-NIR-MIR spectroscopy is explored here an alternative rapid cheap diagnosis quantification severity PCC. Blood samples from 65 patients, previously analyzed lipidomic proteomic studies, along with new were examined to develop model that quantifies based solely spectrophotometric data. Significant spectral variability was observed UV-VIS region, particularly between 297 600 nm, correlating strongly patient symptoms. Unsupervised clustering algorithms this region effectively differentiated asymptomatic symptomatic achieving Jaccard similarity score 0.667 when compared clinical symptom classifications. Comparative indicated captures clinically relevant biochemical information. results developed work quantify demonstrated robustness data, underscoring method's potential rapid, non-invasive, cost-effective diagnostic tool. This study highlights strengths spectroscopic techniques, suggesting their suitability widespread application diagnosing monitoring PCC, emphasizes need further refinement integration into healthcare practice, implementation portable devices.

Language: Английский

Citations

0