Ethnomedicine, antibacterial activity, antioxidant potential and phytochemical screening of selected medicinal plants in Dibatie district, Metekel zone, western Ethiopia

BMC Complementary Medicine and Therapies, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 21, 2024

Abstract Background Medicinal plants play a major role in the delivery of healthcare, particularly among rural population Ethiopia. Plant extracts and their bioactive compounds have been utilized for treatment several diseases. This study was aimed at evaluating antibacterial activity, antioxidant capacity, phytochemical content selected medicinal used Dibatie district, western Methods Study were collected, shade dried, pulverized, extracted by maceration 80% ethanol, subjected to antibacterial, antioxidant, tests. Minimum inhibitory concentration (MIC) determined using 96-well microplates nutrient broth microdilution. Antioxidant activity evaluated 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. Phytochemical screening conducted standard test methods. Results The ethanolic extract Polystachya steudneri Rchb.f. pseudobulbs most active against gram-negative Proteus mirabilis , Salmonella typhimurium Klebsiella pneumoniae Escherichia coli Shigella flexneri with MIC values 8 ± 0, 11 5, 3 1, 2 0 mg/mL, respectively. P. also effective gram-positive Staphylococcus aureus epidermidis Streptococcus agalactiae Enterococcus faecalis 16 Ethanolic Gnidia involucrata Steud. ex A.Rich. stems roots antioxidants, respective 50% DPPH concentrations (IC 50 ) 168.68 181.79 µg/mL, followed that = 203.11 µg/mL). contained alkaloids, anthocyanins, anthraquinones, cardiac glycosides, coumarins, flavonoids, phenols, saponins, steroids, tannins, terpenoids. Conclusions confirmed antibiotic, constituents investigated suggested further investigations may lead compounds.

Language: Английский

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Phytochemical screening of Bixa orellana and preliminary antidiabetic, antibacterial, antifibrinolytic, anthelmintic, antioxidant, and cytotoxic activity against lung cancer (A549) cell lines

Journal of King Saud University - Science, Journal Year: 2023, Volume and Issue: 35(5), P. 102683 - 102683

Published: April 17, 2023

Bixa orellana (B. Orellana) is a frequently utilized plant that has grown in significance pharmaceutical applications. The leaves extract of B. was used the current study for preliminary phytochemical analysis terms both quantitative and qualitative, which indicates presence phenols, alkaloids, flavonoids. Furthermore, demonstrated antifungal activity at 30 mm zone clearance against Candida albicans antibacterial 16 Bacillus nakamuria by well diffusion method different strains. showed MIC 20 µg/mL MBC 157.11 E. coli ELISA broth dilution method, respectively. To evaluate phytochemicals extract, further purification TLC, column chromatography, component GC–MS, reported 18 components, UV spectrum were performed. A number therapeutic applications observed, including antidiabetic (anti-glucosidase) 98.34% inhibition 100 µg/mL, anti-lipase 100% anti-amylase antioxidant (anti-DPPH activity) 59.74% anthelmintic 1 min 1000 antifibrinolytic secs cytotoxic A549 lung cell lines, wherein, viability below 40 % highest dose (100 µg/mL), with an IC50 value 39.9 µg/mL.

Language: Английский

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Evaluation of Antioxidants, Antibacterial and Antidiabetic Activities of Aqua-alcoholic Marjoram Extract

Baghdad Science Journal, Journal Year: 2024, Volume and Issue: 21(8), P. 2660 - 2660

Published: Jan. 19, 2024

تمتلك المستخلصات النباتية أهمية خاصة تجاه صحة الإنسان والأنشطة الحيوية لمجموعة واسعة من الأمراض. هدفت الدراسة الحالية إلى التحقق وجود مكونات فعالة في مستخلص أوراق البردقوش ، وتحديد مضادات الأكسدة المضادة للبكتيريا والفطريات و LD50 ونشاطها المضاد لمرض السكر. تم تحليل المكونات النشطة نوعيا خلال طرائق اختبار محددة. وتم قياس الأنشطة للأكسدة البكتريا بالطرائق القياسية. وحددت الفعالية للسكري عن طريق تقييم ارتفاع السكر وفرط شحميات الدم ووظائف الكبد الطيفية. اكدت النتائج على العديد الفعالة تتضمن مركبات الفلافونويد والقلويدات والتربينويدات والعفص والصابونين. كما أظهرت نتائج فعالية أن يمتلك نشاطًا مضادًا مشابهًا لحمض الأسكوربيك. وأظهرت الجرعة المسموح بها هي 12.5 ملغم / مل. أشارت مضادة لمدى واسع المرضية ولكن لا يوجد تأثير للمستخلص E. coli Staphylococcus aureus حتى عند التراكيز العالية. أظهر عاليًة المعالجته لمدة أسبوعين بـ 4 المستخلص يوميا. مع تحسن مستوى الدهون ومستويات هرمون التستوستيرون بعد العلاج مجموعة مرضى السكري مقارنة التحكم. يمكن الاستنتاج يحتوي عالية حيوية ضد ونشاط عال مضاد تعزيز كبير للخصوبة ومستوى عالٍ الجرعات وفقًا لقيمة LD50.

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Phenols, Flavonoids and Anthocyanins in Solanum lasiocarpum from Borneo: In Vitro Antioxidant Activity and Phytochemical Profiling via LCMS Q-TOF

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104966 - 104966

Published: Aug. 23, 2024

Language: Английский

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The rhizobacterial Priestia megaterium strain SH-19 mitigates the hazardous effects of heat stress via an endogenous secondary metabolite elucidation network and molecular regulation signalling

BMC Plant Biology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 4, 2024

Language: Английский

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A comparison of the antioxidant activity of Turkish Black Tea at various processing stages

Deleted Journal, Journal Year: 2025, Volume and Issue: 5(1), P. 7 - 15

Published: March 16, 2025

Objective: Türkiye is a country where many plants can grow due to its location and climate diversity. Rize, located in the Black Sea region, stands out notably tea cultivation high rainfall humidity. In recent years, studies this field have acquired momentum because of interest natural antioxidants. study, antioxidant properties different processing stages black grown Rize were comparatively examined. Methods: This study presents best combinations stirring time solvent obtain extracts from samples most efficient way. Five methods used for measurement activity, which are as follows: Cupric ion reducing capacity (CUPRAC) method, Ferric potential (FRAP) DPPH (1,1-diphenyl-2-picrylhydrazyl) scavenging activity Ferrous chelating (FIC) total phenolic content (TPC) method. Results: The results obtained CUPRAC, DPPH, TPC strongly support each other. other two also gave similar within themselves. When all examined, it was observed that last stage sample with highest properties, while first least properties. Conclusion: experimental points consumption beneficial helps body get

Language: Английский

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In Vivo and In Vitro Assessment of Marrubium vulgare: Chemical, Antioxidant and Anti-inflammatory Profiles

Arabian Journal for Science and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

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Heterocyclic Betanin from Opuntia stricta var. Dillenii: Purification, Stability, and Effects on Carbohydrate Digestion, Absorption, Metabolism, and Enzyme Inhibition in Obese Rats with Type 2 Diabetes

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106569 - 106569

Published: April 1, 2025

Language: Английский

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Analysis of phytochemical constituents using GC–MS, evaluation of antioxidants and antibacterial activities of Maerua oblongifolia root bark extracts

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(5)

Published: April 28, 2025

Language: Английский

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Chemometric Tools Associated with Quality Parameters for Evaluation of Mauritia flexuosa L.f. Oil in the State of Pará (Brazil)

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1585 - 1585

Published: April 30, 2025

Mauritia flexuosa L.f. oil has high added value due to its antioxidant activity. This study evaluated the quality of 50 samples from eight regions Pará, using analytical and chemometric methods. Total carotenoids, polyphenols, flavonoids, vitamin C, acidity, peroxide, saponification, fatty acid indices were analyzed. Samples with higher residual load identified by Mahalanobis distance. Principal component analysis (PCA) highlighted total carotenoids as most relevant parameter, identifying three groups different levels biological activity (low, medium, high) significant cumulative variance. ANOVA did not indicate differences between regarding acids, but oleic was predominant in five regions. Nine are suitable for food sector, while others can be directed applications. The maximum concentrations C 1899 μg/g, 161.69 GAE/100 g, 125.02 mg EC/100 24.17 mg/100 respectively. demonstrated usefulness tools control this bioinput, facing local bioeconomy.

Language: Английский

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