Discordance Between Triglycerides, Remnant Cholesterol and Systemic Inflammation in Patients with Schizophrenia DOI Creative Commons

Jeffrey Wang,

Maaike Kockx, Gabrielle J. Pennings

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2884 - 2884

Published: Dec. 18, 2024

Background/Objectives: Hypertriglyceridaemia and systemic inflammation are prevalent in patients with schizophrenia contribute to an increased risk of cardiovascular disease. Although elevated triglycerides (TGs) remnant cholesterol linked the general population individuals metabolic syndrome, whether they associated remains unclear. Methods: Fasting levels TG, (total (TC), low-density lipoprotein (LDL-C), high-density (HDL-C) cholesterol)), markers including high-sensitivity C-reactive protein (hsCRP), leukocyte counts their differentials (neutrophils, monocytes lymphocytes) were determined 147 diagnosed on long-term antipsychotic regimens compared 56 age- sex-matched healthy controls. Apolipoprotein B glycosylation acute phase reactant (GlycA) signatures assessed by NMR. Circulating cytokine measured a cytokine/chemokine multiplex assay. Results: Patients had markedly TG relative controls evidence circulating hsCRP, GlycA, leukocyte, neutrophil neutrophil-to-lymphocyte ratio (NLR). Unexpectedly did not correlate inflammatory schizophrenia, differences between persisted after adjusting for lipid profile. Interleukin (IL)-10 suggesting anti-inflammatory signature. Conclusions: The discordance suggests these likely independent contributors this population.

Language: Английский

Discordance Between Triglycerides, Remnant Cholesterol and Systemic Inflammation in Patients with Schizophrenia DOI Creative Commons

Jeffrey Wang,

Maaike Kockx, Gabrielle J. Pennings

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2884 - 2884

Published: Dec. 18, 2024

Background/Objectives: Hypertriglyceridaemia and systemic inflammation are prevalent in patients with schizophrenia contribute to an increased risk of cardiovascular disease. Although elevated triglycerides (TGs) remnant cholesterol linked the general population individuals metabolic syndrome, whether they associated remains unclear. Methods: Fasting levels TG, (total (TC), low-density lipoprotein (LDL-C), high-density (HDL-C) cholesterol)), markers including high-sensitivity C-reactive protein (hsCRP), leukocyte counts their differentials (neutrophils, monocytes lymphocytes) were determined 147 diagnosed on long-term antipsychotic regimens compared 56 age- sex-matched healthy controls. Apolipoprotein B glycosylation acute phase reactant (GlycA) signatures assessed by NMR. Circulating cytokine measured a cytokine/chemokine multiplex assay. Results: Patients had markedly TG relative controls evidence circulating hsCRP, GlycA, leukocyte, neutrophil neutrophil-to-lymphocyte ratio (NLR). Unexpectedly did not correlate inflammatory schizophrenia, differences between persisted after adjusting for lipid profile. Interleukin (IL)-10 suggesting anti-inflammatory signature. Conclusions: The discordance suggests these likely independent contributors this population.

Language: Английский

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