Deep insights into microsampling technologies for global lipidomic profiling of human whole blood using high-throughput LC-MS

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113760 - 113760

Published: April 1, 2025

Language: Английский

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LipidIN: a comprehensive repository for flash platform-independent annotation and reverse lipidomics

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 16, 2025

Improving annotation accuracy, coverage, speed and depth of lipid profiles remains a significant challenge in traditional annotation. We introduce LipidIN, an advanced framework designed for flash platform-independent LipidIN features 168.5-million fragmentation hierarchical library that encompasses all potential chain compositions carbon-carbon double bond locations. The expeditious querying module achieves speeds exceeding one hundred billion queries per second across mass spectral libraries. categories intelligence model is developed using three relative retention time rules, reducing false positive annotations predicting unannotated lipids with 5.7% estimated discovery rate, covering 8923 cross various species. More importantly, integrates Wide-spectrum Modeling Yield network regenerating fragment fingerprints to further improve accuracy coverage 20% recall boosting. demonstrate the utility multiple tasks biomarker clinical cohorts.

Language: Английский

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Lipidomics Unveils Critical Lipid Pathway Shifts in Alport Syndrome

Kidney International Reports, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Bone Fragility in Type 2 Diabetes Mellitus. Influence of Sex and Cardiovascular Disease in a Pilot Study using Metabolomics

Talanta Open, Journal Year: 2024, Volume and Issue: 10, P. 100381 - 100381

Published: Nov. 17, 2024

Language: Английский

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