iScience,
Journal Year:
2024,
Volume and Issue:
27(2), P. 108969 - 108969
Published: Jan. 21, 2024
Magnesium
(Mg)-based
conduits
have
gained
more
attention
in
repairing
peripheral
nerve
defects.
However,
they
are
limited
due
to
poor
corrosion
resistance
and
rapid
degradation
rate.
To
tackle
this
issue,
glial
cell
line-derived
neurotrophic
factor
(GDNF)-
Gelatin
methacryloyl
(Gel)/hydroxylapatite
(HA)-Mg
conduit
was
developed
implanted
sciatic
defect
model
Sprague-Dawley
(SD)
rats.
The
functional
index
measurement
showed
that
the
GDNF-Gel/HA-Mg
effectively
promoted
recovery
of
function.
pathological
examination
results
there
were
regenerated
tissues
group,
with
a
higher
number
regenerating
axons,
thickness
myelin
sheath
significantly
larger
than
control
group
(NC
group).
Immunofluorescence
revealed
expression
genes
associated
repair.
RNA-seq
molecular
test
indicated
might
be
involved
repair
defects
by
regulating
PPAR-γ/RhoA/ROCK
signaling
pathway.
Biological
sciences;
Neuroscience;
Molecular
neuroscience;
Techniques
neuroscience.
Journal of Magnesium and Alloys,
Journal Year:
2024,
Volume and Issue:
12(7), P. 2695 - 2710
Published: June 27, 2024
Traditional
designs
and
developments
of
bone
biomaterials
mostly
concentrate
on
the
positive
regulation
osteoblast
lineage
cells,
but
often
ignore
importance
immune
responses
equilibrium
between
resorption
mediated
by
osteoclasts
formation
osteoblasts.
Immune
dysregulation
is
associated
with
an
imbalance
pro-inflammatory
anti-inflammatory
processes,
which
may
influence
efficacy
therapy.
Therefore,
implanted
should
appropriately
precisely
modulate
subsequent
responses.
Magnesium
(Mg)
has
been
used
to
fabricate
various
Mg
alloys
for
repair
because
its
favorable
attributes
such
as
osteogenic
potential,
characteristics,
biodegradability,
biocompatibility.
Various
basic
research
clinical
trials
have
already
conducted
in
many
countries
explore
physical
properties
Mg-containing
implants
their
outcomes
fracture
defect
repair.
this
review
summarizes
response
implants,
further
organizes
current
development
progress
implants.
The
aims
offer
overview
knowledge
immunomodulation
future
challenges
application,
could
provide
insight
better
strategies
treatment
fracture.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101635 - 101635
Published: March 5, 2025
Magnesium-related
bone
implants
have
garnered
significant
attention
in
the
treatment
of
defects.
The
applications
magnesium
promoting
repair
mainly
include
degradable
magnesium-based
scaffolds
owing
to
its
special
physical
properties
and
composite
materials
modified
by
ions
because
biological
activity.
Although
numerous
studies
confirmed
unique
application
advantages
efficacy
repair,
some
obvious
shortcomings
persist,
including
rapid
degradation
scaffolds.
In
this
review,
deficiencies
alloys
construction
orthopedic
their
key
influencing
factors
were
summarized;
furthermore,
advanced
improvement
schemes
summarized
analyzed.
Additionally,
strategies
magnesium-modified
are
discussed.
Lastly,
review
incorporates
latest
research
discoveries
on
science,
comprehensively
exploring
mechanism
magnesium's
role
complex
microenvironment
defects
from
multiple
dimensions.
This
paper
provides
a
comprehensive
summary
analysis
cutting-edge
concepts
design
development
implants,
considering
various
perspectives
such
as
functions
magnesium.
iScience,
Journal Year:
2024,
Volume and Issue:
27(2), P. 108969 - 108969
Published: Jan. 21, 2024
Magnesium
(Mg)-based
conduits
have
gained
more
attention
in
repairing
peripheral
nerve
defects.
However,
they
are
limited
due
to
poor
corrosion
resistance
and
rapid
degradation
rate.
To
tackle
this
issue,
glial
cell
line-derived
neurotrophic
factor
(GDNF)-
Gelatin
methacryloyl
(Gel)/hydroxylapatite
(HA)-Mg
conduit
was
developed
implanted
sciatic
defect
model
Sprague-Dawley
(SD)
rats.
The
functional
index
measurement
showed
that
the
GDNF-Gel/HA-Mg
effectively
promoted
recovery
of
function.
pathological
examination
results
there
were
regenerated
tissues
group,
with
a
higher
number
regenerating
axons,
thickness
myelin
sheath
significantly
larger
than
control
group
(NC
group).
Immunofluorescence
revealed
expression
genes
associated
repair.
RNA-seq
molecular
test
indicated
might
be
involved
repair
defects
by
regulating
PPAR-γ/RhoA/ROCK
signaling
pathway.
Biological
sciences;
Neuroscience;
Molecular
neuroscience;
Techniques
neuroscience.
