The roles of TAF1 in neuroscience and beyond DOI Creative Commons
Elisa M. Crombie, Karen Cleverley, H. T. Marc Timmers

et al.

Royal Society Open Science, Journal Year: 2024, Volume and Issue: 11(9)

Published: Sept. 1, 2024

The transcriptional machinery is essential for gene expression and regulation; dysregulation of transcription can result in a range pathologies, including neurodegeneration, cancer, developmental disorders cardiovascular disease. A key component RNA polymerase II-mediated the basal factor IID, which formed TATA box-binding protein (TBP) 14 TBP-associated factors (TAFs), largest TAF1 protein, encoded on X chromosome (Xq13.1). dysregulated X-linked dystonia–parkinsonism congenital mutations are causative neurodevelopmental phenotypes; dysfunction also associated with cardiac anomalies cancer. However, how contributes to pathology unclear. Here, we highlight aspects function that may link regulation development, growth adult-onset motor impairment. We need experimentally investigate full messenger variants isoforms human mouse aid our understanding biology. Furthermore, nature -related diseases adds complexity phenotypes. Overall, shed light biology contribute disease areas could be addressed future research targeted therapeutics.

Language: Английский

Orchestrated centers for the production of proteins or “translation factories” DOI Creative Commons
Robert A. Crawford, Matthew Eastham, Martin Pool

et al.

Wiley Interdisciplinary Reviews - RNA, Journal Year: 2024, Volume and Issue: 15(4)

Published: July 1, 2024

The mechanics of how proteins are generated from mRNA is increasingly well understood. However, much less known about protein production coordinated and orchestrated within the crowded intracellular environment, especially in eukaryotic cells. Recent studies suggest that localized sites exist for specific proteins. These have been termed "translation factories" roles complex formation, localization, inheritance, translation regulation postulated. In this article, we review evidence supporting at these sites, details their mechanism likely functional significance. Finally, consider key uncertainties regarding elusive structures This article categorized under: Translation > Mechanisms RNA Export Localization Regulation.

Language: Английский

Citations

1
The roles of TAF1 in neuroscience and beyond DOI Creative Commons
Elisa M. Crombie, Karen Cleverley, H. T. Marc Timmers

et al.

Royal Society Open Science, Journal Year: 2024, Volume and Issue: 11(9)

Published: Sept. 1, 2024

The transcriptional machinery is essential for gene expression and regulation; dysregulation of transcription can result in a range pathologies, including neurodegeneration, cancer, developmental disorders cardiovascular disease. A key component RNA polymerase II-mediated the basal factor IID, which formed TATA box-binding protein (TBP) 14 TBP-associated factors (TAFs), largest TAF1 protein, encoded on X chromosome (Xq13.1). dysregulated X-linked dystonia–parkinsonism congenital mutations are causative neurodevelopmental phenotypes; dysfunction also associated with cardiac anomalies cancer. However, how contributes to pathology unclear. Here, we highlight aspects function that may link regulation development, growth adult-onset motor impairment. We need experimentally investigate full messenger variants isoforms human mouse aid our understanding biology. Furthermore, nature -related diseases adds complexity phenotypes. Overall, shed light biology contribute disease areas could be addressed future research targeted therapeutics.

Language: Английский

Citations

1