An Antibacterial Hydrogel Based on Silk Sericin Cross-Linking Glycyrrhizic Acid and Silver for Infectious Wound Healing DOI
Xiang Li, Yurong Li,

Akoumay Tehoungue

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Bioactive hydrogels are garnering increasing interest in wound management due to their porous structural features and versatile intrinsic biological activities. Importantly, the antibacterial capacity is a crucial requirement for hydrogel dressings chronically infected wounds. In this study, we report an constructed from silk sericin (SS) cross-linked with glycyrrhizic acid (GA) integrated silver ions (Ag+) accelerate healing of bacterial-infected The resultant sericin-glycyrrhizic acid-Ag+ (SGA) demonstrates favorable mechanical properties, effectively preventing secondary injury Moreover, vitro studies indicated that SGA possesses excellent swelling ratios, degradability, cytocompatibility, promoting cell growth proliferation. Notably, exhibited effective activity against both Gram-positive Gram-negative bacteria through release Ag+. Staphylococcus aureus-infected model, efficiently eradicated bacteria, thus repair. Overall, our work establishes novel strategy developing multifunctional based on natural materials managing bacteria-infected

Language: Английский

An Antibacterial Hydrogel Based on Silk Sericin Cross-Linking Glycyrrhizic Acid and Silver for Infectious Wound Healing DOI
Xiang Li, Yurong Li,

Akoumay Tehoungue

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Bioactive hydrogels are garnering increasing interest in wound management due to their porous structural features and versatile intrinsic biological activities. Importantly, the antibacterial capacity is a crucial requirement for hydrogel dressings chronically infected wounds. In this study, we report an constructed from silk sericin (SS) cross-linked with glycyrrhizic acid (GA) integrated silver ions (Ag+) accelerate healing of bacterial-infected The resultant sericin-glycyrrhizic acid-Ag+ (SGA) demonstrates favorable mechanical properties, effectively preventing secondary injury Moreover, vitro studies indicated that SGA possesses excellent swelling ratios, degradability, cytocompatibility, promoting cell growth proliferation. Notably, exhibited effective activity against both Gram-positive Gram-negative bacteria through release Ag+. Staphylococcus aureus-infected model, efficiently eradicated bacteria, thus repair. Overall, our work establishes novel strategy developing multifunctional based on natural materials managing bacteria-infected

Language: Английский

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