LEF1-AS1 Deregulation in the Peripheral Blood of Patients with Persistent Post-COVID Symptoms DOI Open Access
Alisia Madè,

Santiago Nicolas Piella,

Marco Ranucci

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4806 - 4806

Published: May 17, 2025

Long COVID denotes the persistence of symptoms after acute SARS-CoV-2 infection lasting for at least two months without another identifiable cause. Affecting an estimated 15% COVID-19 patients, long manifests in a wide range symptoms. Despite extensive research on its one-year effects, limited data exist beyond 12 months. Due to different manifestations COVID, diagnosis can be challenging. Identifying potential mechanistic contributors and biomarkers would highly valuable. Recent studies have highlighted noncoding RNAs (ncRNAs) as disease stratification COVID-19. Specifically, we recently identified miR-144-3p subset lncRNAs candidates assessing severity outcomes This nested case–control study extends such investigations 98 patients recruited 18 hospitalization, exploring relationship between circulating ncRNA expression persistent While miR-144-3p, HCG18, lncCEACAM21 did not differ symptomatic asymptomatic LEF1-AS1 was downregulated peripheral blood mononuclear cells (PBMCs) patients. Of note, multiple isoforms LEF1 sense transcript levels were reduced negatively correlated with relevant clinical markers. further are needed, our discoveries offer new perspectives management COVID.

Language: Английский

LEF1-AS1 Deregulation in the Peripheral Blood of Patients with Persistent Post-COVID Symptoms DOI Open Access
Alisia Madè,

Santiago Nicolas Piella,

Marco Ranucci

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4806 - 4806

Published: May 17, 2025

Long COVID denotes the persistence of symptoms after acute SARS-CoV-2 infection lasting for at least two months without another identifiable cause. Affecting an estimated 15% COVID-19 patients, long manifests in a wide range symptoms. Despite extensive research on its one-year effects, limited data exist beyond 12 months. Due to different manifestations COVID, diagnosis can be challenging. Identifying potential mechanistic contributors and biomarkers would highly valuable. Recent studies have highlighted noncoding RNAs (ncRNAs) as disease stratification COVID-19. Specifically, we recently identified miR-144-3p subset lncRNAs candidates assessing severity outcomes This nested case–control study extends such investigations 98 patients recruited 18 hospitalization, exploring relationship between circulating ncRNA expression persistent While miR-144-3p, HCG18, lncCEACAM21 did not differ symptomatic asymptomatic LEF1-AS1 was downregulated peripheral blood mononuclear cells (PBMCs) patients. Of note, multiple isoforms LEF1 sense transcript levels were reduced negatively correlated with relevant clinical markers. further are needed, our discoveries offer new perspectives management COVID.

Language: Английский

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