High bacterial coinfection rates and associated mortality among hospitalized older adults with laboratory-confirmed respiratory syncytial virus infection DOI Creative Commons

Yuchang Fu,

Ting‐Wei Lai,

Yuhua Su

et al.

Journal of Microbiology Immunology and Infection, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Emerging evidence highlights that respiratory syncytial virus (RSV) poses a significant risk to older adults. However, detailed clinical data on elderly patients hospitalized with RSV remains limited. This study investigates the characteristics and outcomes of adults (aged ≥50 years) infection. retrospective cohort included aged years symptoms laboratory-confirmed infection at China Medical University Hospital between January 1, 2011, December 31, 2023. Data demographic presentations were collected. infection-related analyzed across various subgroups. 36 patients, most prevalent comorbidities being diabetes mellitus (47.2 %), immunocompromised status (36.1 chronic lung disease (30.6 %). Pneumonia was identified in 72.2 % while 41.7 required invasive mechanical ventilation, hospital mortality rate 33.3 %. Non-survivors had higher rates comorbidities, particularly (66.7 vs. 12.5 %, p = 0.002), severity, elevated procalcitonin levels, more likely develop septic shock acute distress syndrome. A bacterial coinfection observed, experiencing pneumonia or showing poorer outcomes. Moreover, exhibited significantly worse day-28 survival (log-rank < 0.001). The burden is amplified by such as disease, coinfections further worsening Our findings highlight need for comprehensive understanding effective preventive strategies protect this vulnerable population.

Language: Английский

High bacterial coinfection rates and associated mortality among hospitalized older adults with laboratory-confirmed respiratory syncytial virus infection DOI Creative Commons

Yuchang Fu,

Ting‐Wei Lai,

Yuhua Su

et al.

Journal of Microbiology Immunology and Infection, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Emerging evidence highlights that respiratory syncytial virus (RSV) poses a significant risk to older adults. However, detailed clinical data on elderly patients hospitalized with RSV remains limited. This study investigates the characteristics and outcomes of adults (aged ≥50 years) infection. retrospective cohort included aged years symptoms laboratory-confirmed infection at China Medical University Hospital between January 1, 2011, December 31, 2023. Data demographic presentations were collected. infection-related analyzed across various subgroups. 36 patients, most prevalent comorbidities being diabetes mellitus (47.2 %), immunocompromised status (36.1 chronic lung disease (30.6 %). Pneumonia was identified in 72.2 % while 41.7 required invasive mechanical ventilation, hospital mortality rate 33.3 %. Non-survivors had higher rates comorbidities, particularly (66.7 vs. 12.5 %, p = 0.002), severity, elevated procalcitonin levels, more likely develop septic shock acute distress syndrome. A bacterial coinfection observed, experiencing pneumonia or showing poorer outcomes. Moreover, exhibited significantly worse day-28 survival (log-rank < 0.001). The burden is amplified by such as disease, coinfections further worsening Our findings highlight need for comprehensive understanding effective preventive strategies protect this vulnerable population.

Language: Английский

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