Green Synthesis of Silver Nanoparticles from Alhagi graecorum Leaf Extract and Evaluation of Their Cytotoxicity and Antifungal Activity

Journal of Nanomaterials, Journal Year: 2022, Volume and Issue: 2022(1)

Published: Jan. 1, 2022

Green synthesis of silver nanoparticles (AgNPs) using different plant parts has shown a great potential in medicinal and industrial applications. In this study, AgNPs were vitro green synthesized A. graecorum , its antifungal antitumoractivities investigated. Scanning electron microscopy (SEM) image result indicated spherical shape with size range 22‐36 nm by Image J program. The functional groups Fourier‐transform infrared spectroscopy (FTIR) represented the involved reduction ion into nanoparticles. Alhagi inhibited MCF‐7 breast cancer cell line growth increased concentration depend manner, significant differences at 50, 100, 150 μ g/ml concentrations compared to control. Strong activity against Candida species ( C. albicans. glabrata parapsilosis tropicales krusei ) was observed inhibition zone from 14‐22 mm 0.01 mmol/ml 17‐27 0.02 mmol/ml. Based on our findings, it is concluded that can be used as antitumor agent for various therapeutical

Language: Английский

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Anticariogenic Effect of Selenium Nanoparticles Synthesized Using Brassica oleracea

Journal of Nanomaterials, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 9

Published: July 9, 2021

Selenium is a trace element in the human body present various enzymes with antioxidant activities and several functional proteins. This study aimed at synthesizing selenium nanoparticles using Brassica oleracea (broccoli) characterizing assessing antimicrobial effectiveness against cariogenic microorganisms. UV-visible spectrum displayed peak 370 nm which confirms formation of SeNPs. TEM images synthesized showed polydisperse nanoparticles, spherical. The size particles ranged from 10 to 25 nm, average particle obtained was $15.2\pm 1.9\text{nm}$ . SEM were spherical 28 nm. SeNPs effective activity pathogens. extract can be incorporated toothpaste, gums, mouthwashes that are cost-effective biocompatible used for prevention dental caries.

Language: Английский

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Recent Developments in Metallic Nanomaterials for Cancer Therapy, Diagnosing and Imaging Applications

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(2), P. 435 - 435

Published: Feb. 17, 2022

Cancer continues to represent a global health concern, imposing an ongoing need research for better treatment alternatives. In this context, nanomedicine seems be the solution existing problems, bringing unprecedented results in various biomedical applications, including cancer therapy, diagnosing, and imaging. As numerous studies have uncovered advantageous properties of nanoscale metals, review aims present metal-based nanoparticles that are most frequently employed applications. This paper follows description relevant made metal derivatives, hybrids, alloys, further discussing more detail their potential applications management, ranging from delivery chemotherapeutics, vaccines, genes ablative hyperthermia therapies theranostic platforms.

Language: Английский

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Current trends in bio-waste mediated metal/metal oxide nanoparticles for drug delivery

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 71, P. 103305 - 103305

Published: April 8, 2022

Nanoparticles have received much attention in biomedical applications due to their unique physicochemical properties. The metal/metal oxide nanoparticles are involved various applications, including drug delivery, therapy, and diagnosis. Subsequently, many hazardous chemicals organic solvents were utilized synthesize the metallic nanoparticles. Therefore, green synthesis came into limelight overcome economic environmental burden. represents production of that reduce or terminate use materials encourages safety. frequently numerous nanoparticle syntheses include microbes, plants, fruits, other food sources. However, burden on global security limited natural resources creates distress over sustainability. Thus, adopting bio-waste produce highly efficient, biocompatible, economic, eco-friendly could support waste valorization lead present review focuses adopted We thoroughly discussed potential chemicals-mediated different delivery such as tumor targeting, brain stimuli-responsive release followed by large molecules delivery. Consequently, this can open a new road for researchers explore using mediated synthesized Finally, cytotoxicity aspects meticulously compared chemically counterparts.

Language: Английский

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Anticancer Activity of TiO2/Au Nanocomposite Prepared by Laser Ablation Technique on Breast and Cervical Cancers

Optics & Laser Technology, Journal Year: 2022, Volume and Issue: 149, P. 107828 - 107828

Published: Jan. 5, 2022

Language: Английский

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Biogenic synthesis of gold nanoparticles using red seaweed Champia parvula and its anti-oxidant and anticarcinogenic activity on lung cancer

Particulate Science And Technology, Journal Year: 2022, Volume and Issue: 41(2), P. 241 - 249

Published: May 19, 2022

The biocompatible gold nanoparticles (AuNPs) have great potential in the development of next-generation anti-cancer medicine. Here, AuNPs were synthesized through a biogenic method using red marine algae Champia parvula. Cp-AuNPs characterized and confirmed by various spectroscopic techniques. UV spectroscopy analysis found Surface Plasmon Resonance (SPR) peak at 550 nm. accurate size morphology identified Transmission Electron Microscope (TEM) Scanning (SEM) to be 20 nm round shape. crystal nature was X-ray Diffraction (XRD) spectrum. FTIR analytical tool used determine presence organic compounds extract Cp-AuNPs. showed excellent anti-oxidant free radical scavenging ability due anti-oxidant-rich components. Anti-cancer activity investigated on lung cancer (A549) cells demonstrated high potential. Our findings suggested that significant therapeutic for cancer.

Language: Английский

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Galangin-Loaded Gold Nanoparticles: Molecular Mechanisms of Antiangiogenesis Properties in Breast Cancer

International Journal of Breast Cancer, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 14

Published: Feb. 16, 2023

Angiogenesis is important for tissue during normal physiological processes as well in a number of diseases, including cancer. Drug resistance one the largest difficulties to antiangiogenesis therapy. Due their lower cytotoxicity and stronger pharmacological advantage, phytochemical anticancer medications have advantages over chemical chemotherapeutic drugs. In current study, effectiveness AuNPs, AuNPs-GAL, free galangin an agent was evaluated. Different physicochemical molecular approaches been used characterization, cytotoxicity, scratch wound healing assay, gene expression VEGF ERKI MCF-7 MDA-MB-231 human breast cancer cell line. Results obtained from MTT assay show growth reduction time- dose-dependent aspect; also, comparison individual treatment, synergistic impact indicated. CAM results demonstrated galangin-gold nanoparticle capacity suppress angiogenesis chick embryo. Additionally, altering recorded. Taken together, all can conclude that galangin-conjugated gold nanoparticles be promising supplemental drug treatment.

Language: Английский

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Tackling breast cancer with gold nanoparticles: twinning synthesis and particle engineering with efficacy

Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(11), P. 2766 - 2812

Published: Jan. 1, 2024

From HAuCl 4 , nano-gold is synthesized via physical, chemical and green techniques. Systematic engineering with different functionalities shapes into a sword multimodal applicability against breast cancer, but what are the consequences?

Language: Английский

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Advances in Gold Nanoparticles: Synthesis, Functionalization Strategies, and Theranostic Applications in Cancer

Critical Reviews in Therapeutic Drug Carrier Systems, Journal Year: 2024, Volume and Issue: 41(6), P. 1 - 56

Published: Jan. 1, 2024

Cancer is among the leading causes of mortality and morbidity in world. Metallic nanoparticles, especially gold nanoparticles (AuNPs) have emerged to be attractive systems circumvent associated adverse effects. By virtue their unique properties tunable size, shape, composition, optical properties, biocompatibility, minimal toxicity, multivalency, fluorescence-luminescence property surface plasmon resonance; AuNPs potential used as drug delivery systems. It vital ensure that reaches target site action for selective kill cancer cells without harm healthy cells. These can easily functionalized with a wide array ligands like peptides, oligonucleotides, polymers, carbohydrates active targeting specific reduced systemic been in-vestigated carriers gene delivery, or photothermal therapy, diagnosis based on radiation spectroscopy. They theranostic approach overall management superior benefit risk features. In this review, we discussed synthesis different (nanorods, spherical hollow AuNPs), functionalization strategies applications biomedical domain. Various research studies clinical trials application therapeutics are highlighted.

Language: Английский

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Bonding states of gold/silver plasmonic nanostructures and sulfur-containing active biological ingredients in biomedical applications: a review

Physical Chemistry Chemical Physics, Journal Year: 2024, Volume and Issue: 26(23), P. 16407 - 16437

Published: Jan. 1, 2024

As one of the most instrumental components in architecture advanced nanomedicines, plasmonic nanostructures (mainly gold and silver nanomaterials) have been paid a lot attention.

Language: Английский

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