Type‐Transformational BioHJzyme Enabled by Composition Modulation‐Mediated Energy Band Engineering for Diabetic Infectious Wound Healing

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract The dilemma of diabetic infectious wound healing lies in inhibiting the pathogenic colonization and regulating hyperglycemia. pivotal anti‐pathogenic efficiency is focused on confined gradually weaken reactive oxygen species (ROS) yield peculiar micromilieu owing to materials transformation/dissolution. There, type‐transformational bio‐heterojunction enzyme (BioHJzyme) with operando composition‐modulation proposed, which consisted by glucose oxidase (GOx) decorated type‐I FeSe 2 /Cu O heterojunction. It exhibits robust catalytic produce ROS. Followed, heterojunction can be transformed into dual Z‐scheme a composition /CuSe/Cu primed acid meliorative energy band. conducive NIR‐induced capabilities improve ROS yield. GOx consume H as an amplifier. combined followed enhanced powerfully remove colonization. On top that, sample downgrade Forkhead box (FoxO) signaling pathway regulate cell cycle, facilitate proliferation, further promote repairment. This work provides effective feasible antibacterial strategy way thinking for healing.

Language: Английский

---

Bioinspired Composite Hydrogels with Osteogenic, Angiogenic, and Antioxidant Properties for Enhanced Bone Repair

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

The increasing demand of advanced biomedical materials for bone repair and regeneration has spurred significant research in recent years. While traditional hydrogels offer promising biocompatibility easy fabrication, their application reconstruction is often impeded by inadequate structural integrity biological functions. Graphene oxide (GO) emerged as a transformative additive, renowned its exceptional mechanical chemical properties, well ability to enhance the hydrogels. In this study, incorporation GO into chitosan (CS) investigated, achieving bioinspired with enhanced strength stability, which are crucial supporting regeneration. Additionally, self‐assembled synthetic peptide nanofibers (PNFs) employed facilitate biomimetic mineralization hydrogels, critical process effective remodeling. This innovative composite hydrogel not only achieves but also exhibits osteogenic, pro‐angiogenic, antioxidant properties essential repair. novel method takes advantage distinctive GO, PNFs, biomass providing robust material solution potential significantly advance field tissue engineering.

Language: Английский

---

Jahn–Teller-Driven Electronic Modulation of Bio-Heterojunction for Wound Regeneration after Postoperative Tumor Resection

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Abundant ·OH, 1O2, and ·O2- provide an efficient methodology for rapid tumor bacteria killing, whereas a limitation focuses on the catalytic efficiency. Thus, Jahn-Teller-driven electronic modulation of bioheterojunction (bioHJ) platform is developed remedy in diabetic infectious wound regeneration after postoperative resection. The bioHJ composed MoTe2/MnO2 glucose oxidase (GOx). GOx depletes to H2O2, which intercepts their metabolism. H2O2 can be further converted into highly lethal ·OH owing peroxidase-mimetic activity via Jahn-Teller effect, while GSH consumed due its GPx-mimetic activity. Both amplified upon NIR irradiation as NIR-activatable enzyme-mimetic activities. In vivo studies subcutaneous model authenticate ability kill tumor, defeat bacterial infection, accelerate regeneration. This work enlightens powerful resection using engineered bioHJ.

Language: Английский

---

Self-degradable nanoparticles hybrid hydrogel with cascade thermal control and spontaneous ion release for complex bone defect regeneration

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162653 - 162653

Published: April 1, 2025

Language: Английский

---

Selective Metallization of Polyether Ether Ketone Based on UV Laser-Induced Wettability Regulation for 3D Electronics

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Language: Английский

---

Ultrasound-Driven Selenium Nanoparticles Realize Bone Defect Repair through Activating Selenoproteins to Regulate PI3K/AKT Signaling Pathway

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Excessive and variable inflammation in bone defects is a key factor that impedes effective repair. Herein, an ultrasound-controlled composite hydrogel (LNT-SeNPs@Gel) integrating gelatin-methacryloyl lentinan-decorated selenium nanoparticles (LNT-SeNPs) developed, exhibiting strong antioxidant anti-inflammatory properties to remodel the inflammatory microenvironment of defects. This serves as platform for bifunctional ultrasound (ultrasound modulation, USc repairing, USr), facilitating cascade treatment reducing overall period. During phase repair, remotely modulates LNT-SeNPs@Gel hydrogel, regulating release LNT-SeNPs inhibit overproduction reactive oxygen species (ROS) factors, ultimately remodeling microenvironment. Subsequently, USr could activate phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway regulated by selenoproteins enhance osteogenesis MC3T3-E1 cells, thereby accelerating repair process. Consequently, combination significantly improves outcomes reduces period rats. In conclusion, this study implies coordinated integration dual effects promising strategy handling complex lengthy

Language: Английский

---