Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: July 12, 2024
Abstract
Pre-existing
mental
disorders
are
considered
a
risk
factor
for
severe
COVID-19
outcomes,
possibly
because
of
higher
vascular
burden.
Moreover,
an
unconventional
platelet
activation
characterizes
and
contributes
to
inflammatory
thrombotic
manifestations.
In
the
light
inflammation
theory
disorders,
we
hypothesized
that
patients
with
could
be
sensitive
SARS-CoV-2
elicited
activation.
We
investigated
in
141
survivors
at
one
month
after
clearance
virus,
comparing
subjects
or
without
established
pre-existing
diagnosis
disorder
according
DSM-5.
found
platelets
from
positive
history
psychiatric
underwent
more
frequently
than
conventional
no
all.
Such
preferential
was
not
detected
when
previous
were
studied.
When
testing
effects
age,
sex,
on
activation,
GLZM
multivariate
analysis
confirmed
significant
effect
only.
These
findings
suggest
during
acute
disorder,
mediated
by
mechanisms
associated
thromboinflammation.
This
event
have
contributed
outcome
population.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(3), P. 387 - 387
Published: Jan. 22, 2025
Breastfeeding
is
the
best
way
to
provide
newborns
with
crucial
nutrients
and
produce
a
unique
bond
between
mother
child.
Breast
milk
rich
in
nutritious
non-nutritive
bioactive
components,
such
as
immune
cells,
cytokines,
chemokines,
immunoglobulins,
hormones,
fatty
acids,
other
constituents.
Maternal
effects
during
gestation
lactation
can
alter
these
influencing
offspring
outcomes.
Chronic
inflammatory
maternal
conditions,
obesity,
diabetes,
hypertension,
impact
breast
composition.
from
obese
mothers
exhibits
changes
fat
content,
cytokine
levels,
hormonal
concentrations,
potentially
affecting
infant
growth
health.
Similarly,
diabetes
alters
composition
of
milk,
impacting
factors
metabolic
markers.
Other
pro-inflammatory
dyslipidemia
syndrome,
have
been
barely
studied.
Thus,
altered
tension
parameters
described
modifying
its
macronutrients
important
biomolecules,
likely
offspring’s
weight.
This
review
emphasizes
chronic
conditions
on
potential
implications
for
development
through
revision
full-access
original
articles.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 9082 - 9082
Published: Aug. 21, 2024
Kynurenic
acid
(KYNA)
is
an
antioxidant
degradation
product
of
tryptophan
that
has
been
shown
to
have
a
variety
cytoprotective,
neuroprotective
and
neuronal
signalling
properties.
However,
mammalian
transporters
receptors
display
micromolar
binding
constants;
these
are
consistent
with
its
typically
tissue
concentrations
but
far
above
serum/plasma
concentration
(normally
tens
nanomolar),
suggesting
large
gaps
in
our
knowledge
transport
mechanisms
action,
the
main
influx
characterized
date
equilibrative,
not
concentrative.
In
addition,
it
substrate
known
anion
efflux
pump
(ABCC4),
whose
vivo
activity
largely
unknown.
Exogeneous
addition
L-tryptophan
or
L-kynurenine
leads
production
KYNA
also
many
other
co-metabolites
(including
some
such
as
3-hydroxy-L-kynurenine
quinolinic
may
be
toxic).
With
exception
chestnut
honey,
exists
at
relatively
low
levels
natural
foodstuffs.
bioavailability
reasonable,
terminal
element
irreversible
reaction
most
pathways,
might
added
exogenously
without
disturbing
upstream
metabolism
significantly.
Many
examples,
which
we
review,
show
valuable
bioactivity.
Given
above,
review
potential
utility
nutraceutical,
finding
significantly
worthy
further
study
development.
OBM Neurobiology,
Journal Year:
2025,
Volume and Issue:
09(01), P. 1 - 12
Published: Feb. 28, 2025
Interactions
in
the
gut-brain
crosstalk
have
led
to
development
of
an
entirely
new
concept:
"microbiota-gut-brain
axis".
Microbiota
has
gained
considerable
attention
relation
disorders
a
more
neurological
nature,
such
as
neurodevelopmental
and
neuropsychiatric
illnesses
like
autism
spectrum
disorder,
anxiety,
mood
disorders.
This
review
aims
summarize
recent
trends
insights
into
role
consequences
gut
microbiota
brain
health
pediatric
Dysbiosis
may
be
associated
with
increased
risk
diseases
that
lead
different
disruptions
conditions,
including
mental
issues.
During
dysbiosis,
neuropsychological
stress
hormones
usually
affect
oxytocin
GABA
neurons
are
significantly
reduced.
Current
studies
report
major
depression,
cognitive
dysfunction
closely
dysbiosis.
In
last
few
years,
handful
clinical
emerged,
illustrating
potential
for
bidirectional
relationship
interactions
humans.
Perhaps
some
most
crucial
investigations
demonstrating
overlapping
relationships
human
axis
come
from
trials
focusing
on
modulating
noting
significant
correlates.
A
field
is
emerging
gene-editing
technology
could
represent
tool
improve
microbial
characteristics.
approach
particularly
relevant
neurodegenerative
brain-gut
linked
loss
species
and/or
high
pathobiont
load.
Biological Psychiatry Global Open Science,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100482 - 100482
Published: March 1, 2025
The
development
of
posttraumatic
stress
disorder
(PTSD)
is
attributable
to
the
interplay
between
exposure
severe
traumatic
events,
environmental
factors,
and
biological
characteristics.
Blood
brain
imaging
markers
have
been
associated
with
PTSD.
However,
our
knowledge,
no
study
has
systematically
investigated
genetic
relationship
PTSD,
metabolic
biomarkers,
brainwide
imaging.
We
integrated
genome-wide
data
informative
233
3935
imaging-derived
phenotypes
(IDPs).
Pleiotropy
was
assessed
by
applying
global
local
correlation,
colocalization,
genetically
inferred
causality.
observed
significant
overlap
PTSD
glycoprotein
acetyls
(GlycA)
(a
stable
inflammatory
biomarker)
in
2
independent
cohorts
(discovery
r
g
=
0.26,
p
1.00
×
10-4;
replication
0.23,
5.99
10-19).
Interestingly,
there
correlation
anxiety
GlycA
(p
.33).
were
both
correlated
median
T2∗
left
pallidum
(IDP-1444:
0.14,
1.39
10-5;
-0.38,
2.50
10-3,
respectively).
Local
7
regions
<
2.0
10-5),
mapping
genes
related
immune
response,
inflammation,
processes.
Furthermore,
we
identified
1
variant,
rs12048743,
evidence
horizontal
pleiotropy
linking
IDP-1444
(z
17.14,
z
-6.07,
theta
2.06
10-8).
Regional
colocalization
among
GlycA,
IDP-1444,
tissue-specific
transcriptomic
regulation
for
frontal
cortex
testis
(rs12048743-chr1q32.1;
posterior
probability
>
0.8).
While
also
tested
causality
metabolomic
IDPs,
these
not
consistent
across
different
informed
causal
inference
methods.
Our
findings
highlight
a
new
putative
pleiotropic
mechanism
that
links
systemic
inflammation
structure
European Journal of Immunology,
Journal Year:
2025,
Volume and Issue:
55(4)
Published: April 1, 2025
The
gut
microbiota
and
the
immune
system
are
closely
connected,
influencing
early-life
brain
development.
Brain-derived
neurotrophic
factor
(BDNF),
crucial
for
neuronal
development,
has
been
demonstrated
to
be
produced
by
certain
cells.
However,
modulation
of
BDNF
during
bacterial
antigen
metabolite
challenge
remains
elusive.
We
investigate
effects
bacterial-derived
antigens
metabolites
on
secretion
in
human
PBMCs.
Although
levels
were
altered
stimulation,
a
specific
cellular
origin
within
PBMCs
was
indeterminate.
Positive
magnetic
separation
monocytes
eliminated
both
stimulant-induced
reduced
monocyte-platelet
aggregates.
Conversely,
elevated
platelet
counts
significantly
increased
levels,
indicating
that
platelets,
when
interacting
with
exposed
antigens,
likely
dominant
source
PBMC
cultures.
As
previously
described,
platelets
circulating
peripheral
blood
BDNF.
Our
findings
emphasize
importance
interplay
between
immune-blood
cell
complexes
microbial
stimulation
regulating
levels.
This
highlights
necessity
investigating
such
interactions
better
understand
gut-brain
axis.
Seminars in Thrombosis and Hemostasis,
Journal Year:
2024,
Volume and Issue:
50(08), P. 1187 - 1190
Published: June 18, 2024
We
are
very
honored
that
our
2016
review
of
platelet
physiology[1]
is
one
the
top
three
most
downloaded
papers
in
Seminars
and
Thrombosis
Haemostasis
from
2014
to
2023.
But
why
study
physiology?
Because
these
remarkable
little
cells
play
key
roles
many
important
pathophysiological
processes,
including
thrombosis,
hemorrhage,
inflammation,
antimicrobial
host
defense,
wound
healing,
angiogenesis,
tumor
growth
metastasis.[2]
In
addition
primary
disorders
number
function,
platelets
have
a
critical
role
other
common
diseases,
coronary
artery
disease,
stroke,
peripheral
vascular
diabetes
mellitus.[2]
There
remain
incompletely
understood
aspects
physiology
its
relationship
few
examples
which
innate
adaptive
immunity,[3]
[4]
genetic
basis
thrombocytopenia,[5]
activation
coronavirus
disease
2019,[6]
liver
disease,[7]
novel
targets
for
antiplatelet
therapy.[8]
[9]
[10]
science
general,
particular,
can
sometimes
lead
researchers
an
unexpected
new
direction,
as
will
be
discussed
this
commentary
focused
on
between
function
sudden
infant
death
syndrome
(SIDS).
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: May 15, 2024
Abstract
Sudden
infant
death
syndrome
(SIDS)
is
the
leading
cause
of
post-neonatal
mortality,
but
underlying
cause(s)
are
unclear.
A
subset
SIDS
infants
has
abnormalities
in
neurotransmitter,
serotonin
(5-hydroxytryptamine
[5-HT])
and
adaptor
molecule,
14–3–3
pathways
regions
brain
involved
gasping,
response
to
hypoxia,
arousal.
To
evaluate
our
hypothesis
that
is,
at
least
part,
a
multi-organ
dysregulation
5-HT,
we
examined
whether
blood
platelets,
which
have
5-HT
signaling
similar
neurons,
abnormal
SIDS.
We
also
studied
platelet
surface
glycoprotein
IX
(GPIX),
cell
adhesion
receptor
physically
linked
14–3–3.
In
dying
compared
known
causes,
found
significantly
higher
intra-platelet
lower
GPIX.
Serum
plasma
were
elevated
controls.
The
presence
both
brainstem
suggests
global
these
potential
for
platelets
be
used
as
model
system
study
interactions
Platelet
serum
biomarkers
may
aid
forensic
determination
predictive
risk
living
infants.
