The intersection of endocrine signaling and neuroimmune communication regulates neonatal nociception DOI Open Access
Adewale Oluwaseun Fadaka, Adam J. Dourson,

Megan C. Hofmann

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 27, 2024

Neonatal pain is a significant clinical issue but the mechanisms by which produced early in life are poorly understood. Our recent work has linked transcription factor serum response downstream of local growth hormone (GH) signaling to incision-related hypersensitivity neonates. However, it remains unclear if similar contribute inflammatory We found that GH treatment inhibited neonatal myalgia appeared do so through unique signal transducer and activator (STAT) dependent pathway within sensory neurons. The STAT1 regulate peripheral inflammation itself modulation monocyte chemoattractant protein 1 (MCP1) release from Data suggests upregulation, signaling, contributes nociception during muscle novel neuroimmune loop involving cytokine primary afferents. Results could uncover new ways treat

Language: Английский

The intersection of endocrine signaling and neuroimmune communication regulates neonatal nociception DOI Open Access
Adewale Oluwaseun Fadaka, Adam J. Dourson,

Megan C. Hofmann

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 27, 2024

Neonatal pain is a significant clinical issue but the mechanisms by which produced early in life are poorly understood. Our recent work has linked transcription factor serum response downstream of local growth hormone (GH) signaling to incision-related hypersensitivity neonates. However, it remains unclear if similar contribute inflammatory We found that GH treatment inhibited neonatal myalgia appeared do so through unique signal transducer and activator (STAT) dependent pathway within sensory neurons. The STAT1 regulate peripheral inflammation itself modulation monocyte chemoattractant protein 1 (MCP1) release from Data suggests upregulation, signaling, contributes nociception during muscle novel neuroimmune loop involving cytokine primary afferents. Results could uncover new ways treat

Language: Английский

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