Single cell landscape of sex differences in the progression of multiple sclerosis DOI Creative Commons

Soler-Sáez Irene,

Gómez-Cabañes Borja,

Grillo-Risco Rubén

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract Background One of the major challenges in addressing multiple sclerosis is to understand its progression trajectory. The pathological process transitions from acute phases predominantly driven by inflammation progressive clinical profiles where neurodegeneration takes precedence. factors mediating this heterogeneity remain unresolved. However, it known that sex plays a crucial role; females are two three times more likely suffer sclerosis, while males rapid with greater severity. Results We profiled 48,919 central nervous system and 336,934 peripheral immune cells, covering spectrum. generated cell-type specific landscapes, including gene signatures differentially expressed genes, functional profiling, pathway activation, cell-cell communication networks for females, males, their differential profiles. Among our findings, we revealed female neurons may exhibit protective mechanisms against neurodegeneration. In inflammatory-predominant forms, cells present an inflammatory core AP-1 transcription factor, male adaptive higher mitochondrial impairment. Conversely, larger differences reported CD8 + T exhibiting cytolytic promote Complete results can be explored user-friendly interactive webtool https://bioinfo.cipf.es/cbl-atlas-ms/. Conclusions identified brain vary spectrum progression. consider molecular description valuable resources future targeted approaches considering individual.

Language: Английский

Fluimucil as a neuroprotective, is there anything new? Bibliometric study from 1996 to 2024 DOI Creative Commons
ARMAN YURISALDI SALEH, Tirta Darmawan Susanto,

Riezky Valentina

et al.

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 46 - 46

Published: Jan. 8, 2025

Introduction Fluimucil, also known as N-acetylcysteine (NAC), has been used a medicinal drug for treating Alzheimer’s and Parkinson’s disease. Recent research shown NAC’s potential neuroprotective agent, preventing oxidative damage promoting neurodegenerative treatment. This study conducted bibliometric analysis of articles related to NAC use, identifying trends, current correlations between institutions. The findings can help identify unpublished guide future strategies. not only provides public interest in but offers valuable insights research. Methods In this work, literature review methodology is employed gather data from the Scopus database using keywords fluimucil, nac, n-acetylcystein, neuroprotective. Data were analyzed Biblioshiny VOSviewer software produce visualizations maps. We quantitative qualitative analysis. Results trend found are Documents by Year, Author, Affiliations, country or territory, funding sponsor, Factorial Map Of With Highest Contributes, Subject Area, Network Visualization, Overlay visualization scopus Vosviewer, Density Thematic Map, Qualitative Analysis. Conclusions Research on effects (NAC) fluimucil several limitations strengths. It uses trends mechanisms action. However, may be biased differ. significant research, particularly diseases like Parkinson Alzheimer. contributes understanding mechanisms.

Language: Английский

Citations

1
Phosphodiesterase 2 (PDE2) inhibitors: an updated patent review (2017–present) DOI
Bei Zhang, Mei-Yan Jiang,

Weihao Luo

et al.

Expert Opinion on Therapeutic Patents, Journal Year: 2024, Volume and Issue: 34(11), P. 1105 - 1119

Published: Oct. 9, 2024

PDE2 is a dual-specific enzyme that hydrolyzes two intracellular substrates, cAMP and cGMP. mainly distributed in the brain, which indicates can serve as potential target for central nervous system diseases without causing other peripheral side effects. Discovery of new mechanisms inhibitors expected to bring opportunities treatment diseases.

Language: Английский

Citations

1
Single cell landscape of sex differences in the progression of multiple sclerosis DOI Creative Commons

Soler-Sáez Irene,

Gómez-Cabañes Borja,

Grillo-Risco Rubén

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract Background One of the major challenges in addressing multiple sclerosis is to understand its progression trajectory. The pathological process transitions from acute phases predominantly driven by inflammation progressive clinical profiles where neurodegeneration takes precedence. factors mediating this heterogeneity remain unresolved. However, it known that sex plays a crucial role; females are two three times more likely suffer sclerosis, while males rapid with greater severity. Results We profiled 48,919 central nervous system and 336,934 peripheral immune cells, covering spectrum. generated cell-type specific landscapes, including gene signatures differentially expressed genes, functional profiling, pathway activation, cell-cell communication networks for females, males, their differential profiles. Among our findings, we revealed female neurons may exhibit protective mechanisms against neurodegeneration. In inflammatory-predominant forms, cells present an inflammatory core AP-1 transcription factor, male adaptive higher mitochondrial impairment. Conversely, larger differences reported CD8 + T exhibiting cytolytic promote Complete results can be explored user-friendly interactive webtool https://bioinfo.cipf.es/cbl-atlas-ms/. Conclusions identified brain vary spectrum progression. consider molecular description valuable resources future targeted approaches considering individual.

Language: Английский

Citations

0