A Case Report of a Boy With Clinically Mild Encephalopathy and a Reversible Splenial Lesion Associated With Severe Acute Respiratory Syndrome-Coronavirus 2 Infection DOI Open Access
Yuko Moriuchi,

Tatsuo Fuchigami,

Ichiro Morioka

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a high frequency of central nervous system abnormalities, particularly encephalopathy, in children. We report the case nine-year-old boy SARS-CoV-2-associated clinically mild encephalopathy reversible splenial lesion. The patient was admitted to our hospital fever, vomiting, and poor speech. tested positive for SARS-CoV-2 by polymerase chain reaction nasal swab sample. cerebrospinal fluid cell count normal. had low serum sodium level upon admission. Computed tomography brain revealed cerebral edema. Diffusion-weighted magnetic resonance imaging (MRI) transient abnormally signal intensity splenium corpus callosum. Electroencephalography generalized high-voltage slow waves. diagnosed lesion infection. discharged without any neurological sequelae. In conclusion, it useful perform MRI evaluations children impaired consciousness, speech, behavior, considering possibility that they may be early stages encephalopathy.

Language: Английский

Clinical Characteristics of Hospitalized Children With Coronavirus Disease 2019 After the Spread of the BA.5 Omicron Variants in Japan DOI
Jun Tachikawa, Yuta Aizawa, Tatsuki Ikuse

et al.

The Pediatric Infectious Disease Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Background: The spread of the BA.5 Omicron variant severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has increased number hospitalized children. However, impact new omicron subvariants in children remains poorly described. Methods: This prospective observational study evaluated clinical characteristics with coronavirus disease 2019 (COVID-19) 13 hospitals Niigata, Japan, during September 2022–February 2024. data were divided and compared across 3 periods based on dominant subvariants: BA.5/BF.5/BF.7 period (September 2022–April 2023), XBB/EG.5 (May–December 2023) BA.2.86/JN.1 (January–February 2024). In addition, COVID-19 vaccination rates patients those general population. Results: total, 298 period. patients’ median ages 4.7 years period, 1.2 2.4 peak monthly admissions decreased over time, 44, 32, 19 cases/mo respectively. Dehydration/oral intake failure (37.2%, 111/298) febrile seizures (16.8%, 50/298) predominant reasons for hospitalization. 5–11 age (11.1%) 12–15 (38.9%) significantly lower than population (41.5% 71.0%). Conclusions: Although diminished they continued to pose a risk. Continued efforts are needed protect from this evolving virus.

Language: Английский

Citations

1
IFN-γ signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice. DOI Creative Commons
Catherine M. Kerr,

Macie A. Proctor-Roser,

Srivatsan Parthasarathy

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

ABSTRACT Neurotropic viruses are a major public health concern as they can cause encephalitis and other severe brain diseases. Many of these viruses, including flaviviruses, herpesviruses, rhabdoviruses alphaviruses enter the through olfactory neuroepithelium (ONE) in bulbs (OB). Due to low percentage that occurs following infections, it’s thought OBs have specialized innate immune responses eliminate viruses. Murine hepatitis virus strain JHM (JHMV) is model coronavirus causes mice access sensory neurons. We’ve shown JHMV Mac1-mutant virus, N1347A, has decreased replication disease brains mice. Here we further show this replicates poorly OB. However, it unknown which factors restrict N1347A RNA seq analysis infected showed IFNγ was upregulated OB while IFN- β barely detectable at 5 days post-infection. To determine if IFN-γ restricts replication, utilized receptor (IFN-γR) knockout (KO) Surprisingly found WT replicated very whole both IFN-γR KO intranasal infection, though survival weight loss were unaltered. Furthermore, determined microglia primary cells producing during early stages infection. We conclude required for efficient

Language: Английский

Citations

0
Epidemiology and treatment trends for acute encephalopathy under the impact of SARS-CoV-2 pandemic based on a prospective multicenter consecutive case registry DOI Creative Commons

Shoichi Tokumoto,

Masahiro Nishiyama, Hiroshi Yamaguchi

et al.

Journal of the Neurological Sciences, Journal Year: 2025, Volume and Issue: 469, P. 123377 - 123377

Published: Jan. 4, 2025

Language: Английский

Citations

0
Two Chinese children with COVID-19 related acute encephalopathy with restricted diffusion DOI Creative Commons

Wing Ki CHAN,

Eric Kin Cheong YAU,

Ming Wai Kwan

et al.

Brain and Development Case Reports, Journal Year: 2025, Volume and Issue: 3(2), P. 100070 - 100070

Published: March 7, 2025

Language: Английский

Citations

0
A Case Report of a Boy With Clinically Mild Encephalopathy and a Reversible Splenial Lesion Associated With Severe Acute Respiratory Syndrome-Coronavirus 2 Infection DOI Open Access
Yuko Moriuchi,

Tatsuo Fuchigami,

Ichiro Morioka

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a high frequency of central nervous system abnormalities, particularly encephalopathy, in children. We report the case nine-year-old boy SARS-CoV-2-associated clinically mild encephalopathy reversible splenial lesion. The patient was admitted to our hospital fever, vomiting, and poor speech. tested positive for SARS-CoV-2 by polymerase chain reaction nasal swab sample. cerebrospinal fluid cell count normal. had low serum sodium level upon admission. Computed tomography brain revealed cerebral edema. Diffusion-weighted magnetic resonance imaging (MRI) transient abnormally signal intensity splenium corpus callosum. Electroencephalography generalized high-voltage slow waves. diagnosed lesion infection. discharged without any neurological sequelae. In conclusion, it useful perform MRI evaluations children impaired consciousness, speech, behavior, considering possibility that they may be early stages encephalopathy.

Language: Английский

Citations

0