The Brain Toxin Cleansing of Sleep Achieved During Wakefulness
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(3), P. 926 - 926
Published: Jan. 31, 2025
A
primary
purpose
of
sleep
for
humans
is
to
remove
toxins
and
metabolic
wastes
from
the
brain
(e.g.,
Aβ,
tau,
lactate)
that
would
otherwise
build
up
compromise
functionality.
There
are
currently
no
drugs
or
devices
have
been
clinically
shown
in
enhance
toxin
removal,
either
during
wakefulness.
This
perspective
article
focuses
on
a
recently
(re)discovered
major
route
drainage
human
through
meningeal
lymphatic
vessels
(mLVs)
enhancer
their
flow—the
cytokine
Vascular
Endothelial
Growth
Factor
(VEGF).
The
this
present
pre-clinical
clinical
evidence
relevant
new
bioengineered
technology
(Transcranial
Radiofrequency
Treatment;
TRFT)
appears
mLV
flow
increase
cleansing
In
being
both
safe
non-invasive,
TRFT
administered
in-home,
presently
device
called
“MemorEM”.
Two
months
daily
wakefulness
increased
typically
low
plasma/brain
levels
VEGF
Alzheimer’s
Disease
(AD)
subjects,
which
was
associated
with
Aβ
tau
removal
brains
wakefulness—ostensibly
VEGF-increased
flow.
Even
irrespective
baseline
levels,
by
AD
who
also
experienced
notable
reversal
cognitive
impairment
after
TRFT.
Additional
studies
nonetheless
required
firmly
establish
TRFT’s
abilities
performing
duty
sleep,
proposed
as
viable
intervention
counter
decline
nighttime
occurs
aging
multiple
diseases,
most
notably
Disease.
implications
insomnia
deprivation
discussed,
potential
extend
healthy
longevity.
Language: Английский
Lifestyle factors and plasma biomarkers of Alzheimer's disease: A narrative review
The Journal of Prevention of Alzheimer s Disease,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100130 - 100130
Published: March 1, 2025
Alzheimer's
disease
(AD)
is
a
neurodegenerative
disorder
characterised
by
amyloid-β
(Aβ),
tau
hyperphosphorylation
and
neurodegeneration.
Blood-based
biomarkers
are
emerging
as
minimally
invasive
tool
for
detection
monitoring.
This
review
depicts
the
relationships
between
modifiable
lifestyle
factors
(nutrition,
physical
activity
(PA),
sleep,
alcohol
consumption,
smoking,
social
isolation)
plasma
of
AD:
Aβ42,
Aβ40,
Aβ42/40,
phosphorylated
tau,
total
neurofilament
light
chain
(NfL)
glial
fibrillary
acidic
protein.
Limited
evidence
suggests
that
better
nutrition
associated
with
favourable
AD
biomarker
profiles
PA
less
NfL
Aβ,
whilst
poor
sleep
elevated
Aβ.
However,
lack
data
inconsistent
findings
highlight
need
further
investigation
to
substantiate
or
refute
these
trends.
Moreover,
future
research
should
include
analysis
on
according
gender,
metabolic
health
APOE
status.
Considering
growing
emphasis
preventing
delaying
dementia
onset
justified.
Language: Английский
Late‐midlife lifestyle and brain and cognitive changes in individuals on the AD versus non‐AD continuum
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring,
Journal Year:
2025,
Volume and Issue:
17(2)
Published: April 1, 2025
Abstract
INTRODUCTION
We
investigated
whether
a
composite
measure
of
late‐midlife
lifestyle
was
associated
with
(1)
longitudinal
brain
changes
and
(2)
cognitive
when
adjusting
for
these
changes.
METHODS
used
linear
mixed
models
to
examine
the
LIfestyle
BRAin
Health
(LIBRA)
index
in
tau,
white
matter
hyperintensity,
neurodegeneration,
cognition
were
similar
amyloid
positive
(A+;
>
17
Centiloids)
negative
participants.
RESULTS
included
324
individuals
from
Wisconsin
Registry
Alzheimer's
Prevention
(39%
apolipoprotein
E
[
APOE
]
4
carrier,
30%
A+,
prior
baseline
age
67
[50–75]).
The
LIBRA
not
biomarker
trajectories
or
primary
outcome
trajectory.
There
inconsistent
effects
on
secondary
domain‐specific
trajectories.
In
contrast,
tau
neurodegeneration
strongly
DISCUSSION
age‐range
disease‐range
studied,
did
exhibit
meaningful
effect
disease
vascular
accumulation
consistently
Highlights
this
age‐range,
Effects
lifestyle,
if
any,
may
take
more
time
manifest.
Language: Английский
Sleep in the elderly: Healthy sleep for healthy aging
Medicinski podmladak,
Journal Year:
2024,
Volume and Issue:
75(5), P. 13 - 22
Published: Jan. 1, 2024
Sleep
is
a
vital
physiological
process
in
which
humans
spend
almost
one
third
of
their
lives.
Contemporary
lifestyles,
shift
work,
social
jet
lag
and
environmental
blue
light
pollution
significantly
compromise
sleep
quality
all
age
groups,
especially
working
adults
the
elderly.
Poor
has
been
demonstrated
to
be
risk
factor
for
number
diseases,
from
cardiovascular
neurological
including
malignancies.
Aging
identified
connected
with
poor
quality,
making
elderly
people
more
vulnerable
development
somatic
mental
disorders.
Low
accelerates
aging
increases
aging-related
pathologies.
There
are
increased
societal
attempts
sustain
well-being
preserve
health
aged
population
concept
healthy
being
widely
promoted
accepted.
Healthy
recognized
as
pillars
aging,
policies
related
Decade
Aging.
One
major
sleep-related
issues
difficulty
distinguish
effects
on
patterns
those
disruptions
caused
by
primary
disorders,
other
diseases
or
medications.
impaired
hygiene
associated
an
various
chronic
diseases.
Moreover,
essential
cognitive
functions
prevention
decline
memory
impairments
The
relationship
between
neurodegenerative
disorders
seems
bidirectional,
extensively
studied
Parkinson's
disease.
Regular
physical
activity
should
considered
component
management
strategies
elderly,
but
also
preventive
strategy
aging.
Language: Английский