Exploring therapeutical targets and innovative treatments for ischemic stroke: a comprehensive review DOI Creative Commons
Lidija Radenović

Exploration of Neuroprotective Therapy, Journal Year: 2024, Volume and Issue: unknown, P. 459 - 484

Published: Nov. 20, 2024

This review focuses on the current advances in field of therapeutic targets and treatments for stroke. Stroke is a major health problem worldwide, with significant impacts morbidity mortality, considerable burden medical socio-economic systems. provides comprehensive overview state knowledge acute targets. Current stroke like recanalization therapies focus mainly restoring blood flow to brain, reducing cell death, preventing further damage, but have limitations terms efficacy long-term outcomes. Besides (mobile units, telerehabilitation) targets, longer-term such as neuroprotection neuroregeneration. Neuroprotective strategies target mechanisms underlying energy failure, cellular acidosis, mitochondrial dysfunction, endoplasmic reticulum stress, excitotoxicity, calcium channels dysregulation, oxidative neuroinflammation, blood-brain barrier disruption, apoptosis, ischemia-reperfusion injury. Neuroregenerative approaches include stem therapy, gene growth factors, rehabilitation techniques that promote rewiring neuronal circuits brain. Non-pharmacological neurostimulation bioengineering are also presented. Additionally, we highlight challenges future directions translating these into clinical practice. Overall, treatment ischemic complex multifaceted process requires combination measures well brain repair recovery. The has made progress recent years development new ongoing research improve outcomes patients. However, before can be successfully integrated routine practise, needed establish standardised protocols, overcome methodological limitations, challenges. By deepening our understanding pathophysiology developing innovative treatments, quality life survivors.

Language: Английский

Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection DOI Creative Commons
Marine Fleury, Lawrence P. Binding, Peter N. Taylor

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 15, 2025

Abstract Approximately 40% of individuals undergoing anterior temporal lobe resection for epilepsy experience episodic memory decline. There has been a focus on early network changes; longer-term plasticity and its impact function are unclear. Our study investigates neural mechanisms recovery over nearly decade post-surgery. We assess changes, from 3–12 months to 10 years postoperatively, in 25 patients (12 left-sided resections) relative healthy matched controls, using longitudinal task-based functional MRI standard neuropsychology assessments. observe key adaptive changes networks predominantly seizure-free cohort. Ongoing neuroplasticity posterior medial regions contralesional cingulum or pallidum contribute long-term verbal visual recovery. Here, we show the potential sustained cognitive improvement importance strategic approaches treatment, advocating conservative surgeries use rehabilitation ongoing

Language: Английский

Citations

0
Exploring therapeutical targets and innovative treatments for ischemic stroke: a comprehensive review DOI Creative Commons
Lidija Radenović

Exploration of Neuroprotective Therapy, Journal Year: 2024, Volume and Issue: unknown, P. 459 - 484

Published: Nov. 20, 2024

This review focuses on the current advances in field of therapeutic targets and treatments for stroke. Stroke is a major health problem worldwide, with significant impacts morbidity mortality, considerable burden medical socio-economic systems. provides comprehensive overview state knowledge acute targets. Current stroke like recanalization therapies focus mainly restoring blood flow to brain, reducing cell death, preventing further damage, but have limitations terms efficacy long-term outcomes. Besides (mobile units, telerehabilitation) targets, longer-term such as neuroprotection neuroregeneration. Neuroprotective strategies target mechanisms underlying energy failure, cellular acidosis, mitochondrial dysfunction, endoplasmic reticulum stress, excitotoxicity, calcium channels dysregulation, oxidative neuroinflammation, blood-brain barrier disruption, apoptosis, ischemia-reperfusion injury. Neuroregenerative approaches include stem therapy, gene growth factors, rehabilitation techniques that promote rewiring neuronal circuits brain. Non-pharmacological neurostimulation bioengineering are also presented. Additionally, we highlight challenges future directions translating these into clinical practice. Overall, treatment ischemic complex multifaceted process requires combination measures well brain repair recovery. The has made progress recent years development new ongoing research improve outcomes patients. However, before can be successfully integrated routine practise, needed establish standardised protocols, overcome methodological limitations, challenges. By deepening our understanding pathophysiology developing innovative treatments, quality life survivors.

Language: Английский

Citations

1