A Systematic Review of Delta-9-Tetrahydrocannabinol (∆9-THC) in Astrocytic Markers DOI Creative Commons
Christian Ramos-Jiménez,

Sarah Petkau,

Romina Mizrahi

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1628 - 1628

Published: Sept. 29, 2024

Background: Astrocytic reactivity in substance use disorders (SUDs) has been extensively studied, yet the molecular effect of delta-9-tetrahydrocannabinol (∆9-THC, main psychoactive compound cannabis) on glial cells, especially astrocytes, remains poorly understood. Exploring ∆9-THC’s impact astrocytic markers can provide insight into its effects brain functions such as homeostasis, synaptic transmission, and response to neuronal injury. This systematic review synthesizes findings from studies investigating markers. Methods: A was conducted using EMBASE, Medline, PsychoInfo via OvidSP platform. Studies reporting following ∆9-THC exposure animals humans were included. Data extracted twelve eligible full-text articles, risk bias assessed Systematic Review Center for Laboratory Animal Experimentation. Results: research identified several markers, including fibrillary acidic protein (GFAP), nestin, glutamate–aspartate transporter (GLAST). Both GFAP nestin expressions increased adulthood adolescence adult exposure. An increase GLAST expression also noted during early development after Conclusions: indicates varying levels across different developmental stages, adulthood. appears maturation, particularly exhibits sex-dependent effects.

Language: Английский

A Systematic Review of Delta-9-Tetrahydrocannabinol (∆9-THC) in Astrocytic Markers DOI Creative Commons
Christian Ramos-Jiménez,

Sarah Petkau,

Romina Mizrahi

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1628 - 1628

Published: Sept. 29, 2024

Background: Astrocytic reactivity in substance use disorders (SUDs) has been extensively studied, yet the molecular effect of delta-9-tetrahydrocannabinol (∆9-THC, main psychoactive compound cannabis) on glial cells, especially astrocytes, remains poorly understood. Exploring ∆9-THC’s impact astrocytic markers can provide insight into its effects brain functions such as homeostasis, synaptic transmission, and response to neuronal injury. This systematic review synthesizes findings from studies investigating markers. Methods: A was conducted using EMBASE, Medline, PsychoInfo via OvidSP platform. Studies reporting following ∆9-THC exposure animals humans were included. Data extracted twelve eligible full-text articles, risk bias assessed Systematic Review Center for Laboratory Animal Experimentation. Results: research identified several markers, including fibrillary acidic protein (GFAP), nestin, glutamate–aspartate transporter (GLAST). Both GFAP nestin expressions increased adulthood adolescence adult exposure. An increase GLAST expression also noted during early development after Conclusions: indicates varying levels across different developmental stages, adulthood. appears maturation, particularly exhibits sex-dependent effects.

Language: Английский

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