Biotransformation of phytochemicals: Way forward to gut microbial, nutraceuticals and herbal therapeutics advancements

Functional Food Science - Online ISSN 2767-3146, Journal Year: 2024, Volume and Issue: 4(3), P. 96 - 118

Published: March 25, 2024

Mammalian gastrointestinal tract is inhabited by trillions of symbiotic microbiotas representing viruses, bacteria, archaea and eukaryotes including yeasts, fungi protozoa. Compared to humans, the herbivores harbor a complex metabolically efficient microbes which not only detoxify inadvertently consumed anti-nutritional phytochemicals, but also convert ingested tannin-polyphenols, saponins, phytoestrogens alkaloids into metabolites are more available bioactive than their precursors. Some toxicants eliminate them from body. The resulting display range nutritional therapeutic benefits besides direct impact on enhancing diversity functioning gut microbiome. Metabolically active microbiota generated might be futuristic alternative biotherapeutics develop nutraceuticals plant-based health formulations primarily for ‘metabotype 0’ individuals. Further insights novel microbial species, modes biotransformation phytochemicals botanicals will pave way non-antibiotic interventions avert infections boost human veterinary health. Keywords: Gut microbiome; Phytochemicals; Biotransformation; Biotherapeutics Highlights: dietary prevent host against chronic diseases infections. Little known about metabolism action GI herbal supplements. having anti-inflammatory, anti-oxidative anti-carcinogenic properties therapeutics.

Language: Английский

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The Potential Therapeutic Role of Curcumin in Osteoporosis Treatment Based on Multiple Signaling Pathways

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(2), P. 19 - 24

Published: June 7, 2024

Osteoporosis is a common bone disease that occurs when the body makes too little bone, loses much or both. This bones weak and more likely to break. Scientists are studying how treat osteoporosis using natural substances found in food medicine. One of these curcumin, which comes from roots plants ginger family. Curcumin has different components like phenols, terpenes, flavonoids. Research shows curcumin can help by affecting cells grow change. It also interfere with signals tell make break down bone. helps prevent multiple ways. Studying works against us find new ways this condition.

Language: Английский

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Protective effects of arecanut seed phenols in retinoic acid induced osteoporosis and the potential mechanisms explored by network pharmacology

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 10, 2024

Arecanut seed is an important traditional medicine in Southeast Asia. It has been presented a clinical formula to treat osteoporosis (OP) China. abundant phenols. However, most of current studies mainly focused on estrogen-deficient model arecanut phenols (ASP), there still lack roundly research about molecular mechanism ASP therapy OP and its influence drug-induced bone loss.

Language: Английский

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Role of cacao (Theobroma cacao L.) extracts in alveolar bone remodeling in diabetic rats during orthodontic tooth movements

Journal of Advanced Pharmaceutical Technology amp Research, Journal Year: 2024, Volume and Issue: 15(4), P. 309 - 314

Published: Oct. 1, 2024

Orthodontic tooth movement (OTM) in diabetes can increase alveolar bone resorption and decrease formation. Cacao beans contain several bioactive compounds that osteoblast differentiation mineralization inhibit osteoclastogenesis to maintain stability. We explored the role of cacao extracts on remodeling diabetic rats during OTM. were assayed for phytochemical screening antioxidant capacity. Twenty-five divided into nondiabetes, diabetes, 125, 250, 125 groups. Diabetes was induced by injecting with streptozotocin 5 days. An orthodontic device inserted between maxillary incisors, extract administered orally. Furthermore, enzyme-linked immunosorbent assay methods used analyze alkaline phosphatase (BALP) receptor activators nuclear factor kappa-B ligand (RANKL) levels. Tartrate-resistant acid (TRAP) expression analyzed using immunohistochemical staining, osteoclast/osteoblast ratio observed through hematoxylin–eosin staining. The data analysis variance post hoc tests, P < 0.05 being statistically significant. contained 7.27% phenolic, 0.02% flavonoid, 1.63% tannin content, 147.47 µg/g half-maximal inhibitory concentration. Approximately 250 mg/kg body weight significantly increased BALP levels decreased RANKL levels, TRAP expression, group ( 0.05). promote OTM reducing increasing deposition.

Language: Английский

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Polyphenols and Functionalized Hydrogels for Osteoporotic Bone Regeneration

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Osteoporosis induces severe oxidative stress and disrupts bone metabolism, complicating the treatment of defects. Current therapies often have side effects require lengthy regeneration periods. Hydrogels, known for their flexible mechanical properties degradability, are promising carriers drugs bioactive factors in tissue engineering. However, they lack ability to regulate local pathological environment osteoporosis expedite repair. Polyphenols, with antioxidative, anti‐inflammatory, metabolism‐regulating properties, emerged as a solution. Combining hydrogels polyphenols, polyphenol‐based can metabolism while providing support adhesion, promoting osteoporotic regeneration. This review first provides brief overview types polyphenols mechanisms facilitating antioxidant, modulation modulating osteoporosis. Next, this examines recent advances defects, including use angiogenesis, modulation, drug delivery, stem cell therapy. Finally, it highlights latest research on polyphenol defect Overall, aims facilitate clinical application

Language: Английский

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Anti-Osteoclastogenesis Potential of Cocoa Pod Husk (Theobroma cacao L.) Extract: In Silico and In Vivo Study

Brazilian Dental Journal, Journal Year: 2024, Volume and Issue: 35

Published: Jan. 1, 2024

Abstract Periodontitis is a common chronic inflammatory disease characterized by alveolar bone loss. The high polyphenol content in cocoa pod husk (Theobroma cacao L) has the potential to influence metabolism and contribute inhibition of resorption. aim this study was analyze anti-osteoclastogenesis L.) both silico vivo study. An analysis T. bioactive compounds conducted using molecular docking simulations. Thirty male Wistar rats (Rattus novergicus) were randomly assigned control negative groups (placebo gel), positive (2% doxycycline treatment (10% (CPH) extract with measurements taken on days 7 14. induced 0.05 ml P. gingivalis at concentration 2x109 CFU/ml intrasulcularly maxillary molar achieved periodontitis. number osteoclasts observed hematoxylin eosin staining, level TNF-α assessed enzyme-linked immunosorbent assay, expression RANKL evaluated immunohistochemical staining. Data analyzed One-way ANOVA examine differences between groups. showed that catechin, epicatechin, quercetin, procyanidin B2 had strong binding affinity for RANKL. Administration 10% CPH reduced (p<0.05), 14 day (p<0.05) experimental Administering inhibited osteoclastogenesis periodontitis rats.

Language: Английский

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Correlation and mediation analysis between plasmapheresis donation behavior and bone mineral density and bone metabolism biomarkers: a cross-sectional study based on plasmapheresis donors at high risk of osteoporosis in China

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e18589 - e18589

Published: Dec. 19, 2024

Background As a group of more than 3.67 million people, the bone health Chinese plasmapheresis donors, which main population is also risk osteoporosis (OP), has raised concerns. Therefore, this article investigates relationship between mineral density (BMD), metabolism indicators, and donation behavior among some high-risk donors for OP in China, further explores mediating factors through reasonable statistical methods. Methods Recruiting long-term highly active new to measure total calcium, albumin (ALB), 25-hydroxy vitamin D (25OHD), parathyroid hormone (PTH), type I procollagen amino-terminal peptide (P1NP), collagen carboxy-terminal ( β -CTX) serum ferritin (SF). Then, multiple linear regression was used adjust confounding factors. Using restrictive cubic splines explore nonlinear relationship. Bootstrap method, investigate whether SF effect biomakers. Finally, analyze differences BMD two. Results Compared repeat have lower 25OHD, -CTX levels, while P1NP PTH levels are high, with differences. The analysis results show that level partial factor biomakers, ratio 21.8%. There no significant difference Conclusion Long-term frequently does not affect mass even elderly at high under existing collection standards anticoagulant use China. However, as self-regulation way, it increase osteogenic activity body.

Language: Английский

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The Interplay of Plant-Based Antioxidants, Inflammation, and Clinical Outcomes in Asthma: A Systematic Review

Respiratory Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 107918 - 107918

Published: Dec. 1, 2024

Language: Английский

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Sodium cholate-coated Olea europaea polyphenol nanoliposomes: Preparation, stability, release, and bioactivity

Food Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 142580 - 142580

Published: Dec. 1, 2024

Language: Английский

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