Changes in Liver Metabolome Induced by Pterostilbene and Resveratrol in a Rat Model of Liver Steatosis DOI Creative Commons
Alfredo Fernández‐Quintela, Emily P. Laveriano‐Santos, Tania Portolés

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

ABSTRACT To gain more light on the effects of resveratrol and pterostilbene in hepatic metabolic modifications an vivo model diet‐induced steatosis, to explore their relationships with gut microbiota by untargeted metabolomics metagenomics. Rats were divided into five groups receiving either a standard diet or high‐fat high‐fructose (HFHF) supplemented not (15 30 mg/kg body weight/day; PT15 PT30 groups, respectively) (30 RSV30 group). Supplementation stilbenes reduced steatosis induced HFHF diet. After study, 27 differentially expressed metabolites showed variable importance projection scores > 1 could be considered as potential biomarkers. Therefore, based pathway enrichment analysis, “riboflavin metabolism” “nicotinate nicotinamide revealed significant enrichment. Further, riboflavin positive correlations Eubacterium Faecalibacterium , negative Lactobacillus Oscillospira genera. Nicotinamide mononucleotide was only positively correlated Ralstonia genus. The approach that actions prevention liver are mediated specific mechanisms action. Particularly, pterostilbene, but resveratrol, is suggested significantly enrich nicotinate pathways.

Language: Английский

Changes in Liver Metabolome Induced by Pterostilbene and Resveratrol in a Rat Model of Liver Steatosis DOI Creative Commons
Alfredo Fernández‐Quintela, Emily P. Laveriano‐Santos, Tania Portolés

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

ABSTRACT To gain more light on the effects of resveratrol and pterostilbene in hepatic metabolic modifications an vivo model diet‐induced steatosis, to explore their relationships with gut microbiota by untargeted metabolomics metagenomics. Rats were divided into five groups receiving either a standard diet or high‐fat high‐fructose (HFHF) supplemented not (15 30 mg/kg body weight/day; PT15 PT30 groups, respectively) (30 RSV30 group). Supplementation stilbenes reduced steatosis induced HFHF diet. After study, 27 differentially expressed metabolites showed variable importance projection scores > 1 could be considered as potential biomarkers. Therefore, based pathway enrichment analysis, “riboflavin metabolism” “nicotinate nicotinamide revealed significant enrichment. Further, riboflavin positive correlations Eubacterium Faecalibacterium , negative Lactobacillus Oscillospira genera. Nicotinamide mononucleotide was only positively correlated Ralstonia genus. The approach that actions prevention liver are mediated specific mechanisms action. Particularly, pterostilbene, but resveratrol, is suggested significantly enrich nicotinate pathways.

Language: Английский

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