Gut microbiota in hepatocellular carcinoma immunotherapy: immune microenvironment remodeling and gut microbiota modification

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 1, 2025

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, with limited treatment options at advanced stages. The gut microbiota, diverse community microorganisms residing in the gastrointestinal tract, plays pivotal role regulating immune responses through gut-liver axis. Emerging evidence underscores its impact on HCC progression and efficacy immunotherapy. This review explores intricate interactions between microbiota system HCC, focus key cells pathways involved tumor immunity. Additionally, it highlights strategies for modulating – such as fecal transplantation, dietary interventions, probiotics potential approaches to enhancing immunotherapy outcomes. A deeper understanding these mechanisms could pave way novel therapeutic aimed improving patient prognosis.

Language: Английский

Gut microbiome, a potential modulator of neuroepigenome

The Journal of Nutritional Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109961 - 109961

Published: May 1, 2025

Language: Английский

In Silico Analysis of Probiotic Bacteria Changes Across COVID-19 Severity Stages

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2353 - 2353

Published: Nov. 18, 2024

The gut microbiota plays a crucial role in modulating the immune response during COVID-19, with several studies reporting significant alterations specific bacterial genera, including

Language: Английский