Hepatoprotective Effects of Citri reticulatae Pericarpium and Chaenomelese speciosa (Sweet) Nakai Extracts in Alcohol-Related Liver Injury: Modulation of Oxidative Stress, Lipid Metabolism, and Gut Microbiota DOI Creative Commons

Shuangshuang Ma,

Lingtao Kang,

Zhipeng Gao

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 343 - 343

Published: March 14, 2025

Chronic and excessive alcohol consumption induces alcohol-related liver injury (ALI), characterized by oxidative stress (OS), disrupted lipid metabolism, gut microbiota dysbiosis. Given the lack of effective pharmacological treatments, flavonoid-rich fruits have attracted growing attention as potential intervention strategies. This study investigated independent combined effects extracts from Citri reticulatae pericarpium (CRPE) Chaenomeles speciosa (Sweet) Nakai (CSPE), previously shown to possess hepatoprotective properties, in a mouse model ethanol-induced chronic ALI. The flavonoid composition CRPE CSPE was using LC-MS/MS, their mechanisms action were further elucidated through transcriptomic analysis. results showed that CSPE, whether administered individually or combination, effectively alleviated alcohol-induced hepatic histological damage inflammatory responses. Furthermore, both significantly reduced OS improved metabolism. Notably, CRPE, combination regulated microbiota, increased abundances beneficial bacteria such Lactobacillus Bifidobacterium, along with elevated levels short-chain fatty acids (SCFAs). These findings highlight combinations multiple fruit exhibit significant alleviating ALI modulating providing valuable insights for development functional foods.

Language: Английский

Hepatoprotective Effects of Citri reticulatae Pericarpium and Chaenomelese speciosa (Sweet) Nakai Extracts in Alcohol-Related Liver Injury: Modulation of Oxidative Stress, Lipid Metabolism, and Gut Microbiota DOI Creative Commons

Shuangshuang Ma,

Lingtao Kang,

Zhipeng Gao

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 343 - 343

Published: March 14, 2025

Chronic and excessive alcohol consumption induces alcohol-related liver injury (ALI), characterized by oxidative stress (OS), disrupted lipid metabolism, gut microbiota dysbiosis. Given the lack of effective pharmacological treatments, flavonoid-rich fruits have attracted growing attention as potential intervention strategies. This study investigated independent combined effects extracts from Citri reticulatae pericarpium (CRPE) Chaenomeles speciosa (Sweet) Nakai (CSPE), previously shown to possess hepatoprotective properties, in a mouse model ethanol-induced chronic ALI. The flavonoid composition CRPE CSPE was using LC-MS/MS, their mechanisms action were further elucidated through transcriptomic analysis. results showed that CSPE, whether administered individually or combination, effectively alleviated alcohol-induced hepatic histological damage inflammatory responses. Furthermore, both significantly reduced OS improved metabolism. Notably, CRPE, combination regulated microbiota, increased abundances beneficial bacteria such Lactobacillus Bifidobacterium, along with elevated levels short-chain fatty acids (SCFAs). These findings highlight combinations multiple fruit exhibit significant alleviating ALI modulating providing valuable insights for development functional foods.

Language: Английский

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