Prunin: An Emerging Anticancer Flavonoid

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2678 - 2678

Published: March 16, 2025

Despite the substantial advances in cancer therapies, developing safe and effective treatment methodologies is critical. Natural (plant-derived compounds), such as flavonoids, might be crucial a methodology without toxicity toward healthy tissues. Prunin flavonoid with potential to used biomedical applications. has yet undergo thorough scientific research, its precise molecular mechanisms of action remain largely unexplored. This review summarizes therapeutic prunin for first time, focusing on underlying an anticancer compound. gained significant attention due antioxidant, anti-inflammatory, effects. aims unlock how functions at level exert effects, primarily modulating key cellular pathways. Furthermore, we have discussed prunin’s adjunctive therapy conventional treatments, highlighting ability strengthen responses while decreasing drug resistance. Moreover, discussion probes into innovative delivery methods, particularly nanoformulations, that address bioavailability, solubility, stability limitations optimize application. By providing comprehensive analysis properties, this stimulate further exploration using agent, thereby progressing development targeted, selective, safe, methods.

Language: Английский

FAAH Modulators from Natural Sources: A Collection of New Potential Drugs

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 551 - 551

Published: April 5, 2025

The endocannabinoid system (ECS) plays a crucial role in maintaining homeostasis by regulating immune response, energy metabolism, cognitive functions, and neuronal activity. It consists of endocannabinoids (eCBs), cannabinoid receptors (CBRs), enzymes involved eCB biosynthesis degradation. Increasing evidence highlights the involvement ECS under several pathological conditions, making it promising therapeutic target. Recent research efforts have focused on modulating endogenous levels, particularly through inhibition fatty acid amide hydrolase (FAAH), main catabolic enzyme major anandamide. Natural substances, including plant extracts purified compounds, can inhibit FAAH represent area pharmacological research. inhibitors are attractive due to their potentially lower toxicity compared synthetic them safer candidates for applications. Phytocannabinoids, flavonoids, flavolignans been shown efficiently FAAH. structural diversity bioactivity these natural substances provide valuable alternative inhibitors, may open new avenues developing innovative tools.

Language: Английский