The Mouth as a Site of SARS-CoV-2 Infection DOI Creative Commons
Natalie Atyeo, Paola Pérez, Bruno Fernandes Matuck

et al.

Current Oral Health Reports, Journal Year: 2024, Volume and Issue: 11(2), P. 167 - 176

Published: Feb. 21, 2024

Abstract Purpose of Review During the height coronavirus pandemic, oral cavity was recognized as a critically important site for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The purpose this review is to analyze literature surrounding SARS-CoV-2 entry, replication, and transmission resulting impact on host tissues in cavity. Recent Findings detection viral genetic material saliva allows widespread surveillance testing emphasizes importance through shed saliva. As cohort patients who have recovered from infection grows, several questions remain about long-term impacts tissues, including whether may serve persistent reservoir. Therefore, thorough understanding life cycle diverse warranted. We conclude with broad outlook effects how these relate post-acute sequelae experienced by patients. Summary can enter replicate be spread between individuals via Several manifestations been reported, lingering are an area ongoing investigation.

Language: Английский

4D-DIA Proteomics Uncovers New Insights into Host Salivary Response Following SARS-CoV-2 Omicron Infection DOI Creative Commons
Iasmim Lopes de Lima, Thaís Regiani Cataldi, Carlos Brites

et al.

Journal of Proteome Research, Journal Year: 2025, Volume and Issue: 24(2), P. 499 - 514

Published: Jan. 13, 2025

Since late 2021, Omicron variants have dominated the epidemiological scenario as most successful severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sublineages, driving new and breakthrough infections globally over past two years. In this study, we investigated for first time host salivary response of COVID-19 patients infected with (BA.1, BA.2, BA.4/5) by using an untargeted four-dimensional data-independent acquisition (4D-DIA)-based proteomics approach. We identified 137 proteins whose abundance levels differed between positive negative groups. Salivary signatures were mainly enriched in ribosomal proteins, linked to mRNAviral translation, protein synthesis processing, immune innate, antiapoptotic signaling. The higher 14-3-3 (YWHAG, YWHAQ, YWHAE, SFN) saliva, reported here, may be associated increased infectivity improved viral replicative fitness. also seven (ACTN1, H2AC2, GSN, NDKA, CD109, GGH, PCYOX) that yielded comprehension into infection performed outstandingly screening a hospital setting. This panel presented enhanced anti-COVID-19 anti-inflammatory signature, providing insights disease severity, supported comparisons other proteome data sets. signature provided valuable host's SARS-CoV-2 infection, shedding light on pathophysiology COVID-19, particularly cases mild disease. It underscores potential clinical applications saliva settings. Data are available via ProteomeXchange identifier PXD054133.

Language: Английский

Citations

0
Natural and induced immune responses in oral cavity and saliva DOI Creative Commons

Michele Matsuoka,

Salim Abraham Soria,

Julien Rodrigues Pires

et al.

BMC Immunology, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 18, 2025

Language: Английский

Citations

0
Impact of social distancing from the COVID-19 pandemic on the immuno-inflammatory response of older adults DOI Creative Commons

Giulia Beletato Nery,

Carlos Ariel Rodrigues de Araújo,

Giovanna Beatriz da Silva

et al.

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 26, 2024

Abstract Background Older adults, as the population considered at increased risk for severe COVID-19, were most impacted by social isolation. Thus, this study aimed to assess salivary immune/inflammatory response of older adults before and during COVID-19 pandemic. Methods A cohort 11 (mean age 66.8 ± 6.1) was followed three different time points: (S1) after 6 (S2) 20 months (S3) beginning pandemic in Brazil. Unstimulated saliva samples obtained levels antibodies (secretory IgA, IgG IgM) ELISA cytokines (IL-2, IL-5, IL-6, IL-8 IL-10, TSLP, IFN-γ, TNF-α) multiplex analysis. Significant differences evaluated using Kruskal–Wallis test with Dunn's post-test. Results None volunteer presented periodontal disease or caries. All volunteers received least two doses vaccines S2 S3. tendency increase SIgA IgM S3 observed compared values found S1 S2. Significantly decreased IL-2 IL-5 ( p < 0.001) points. Lower IFN-γ 0.01). significant decrease IFN-γ/IL-10 ratio When assessing Th1/Th2 ratios, a IFN-γ/TSLP when S1. In addition, TNF-α/IL-5 comparison similar way, an TNF-α/IL-6 (Fig. 5E) Conclusions Overall, provides valuable insights into impact COVID-19-induced isolation on responses upper airway mucosa, particularly those present oral cavity, adults. It demonstrates that controlled shift Th1 Th2 immune responses, both infection post-vaccination, can create favorable conditions combat viral infections without exacerbating worsening pathology.

Language: Английский

Citations

1
Convergence of inflammatory response: Salivary cytokine dynamics in coronavirus disease 2019 and periodontal disease DOI Creative Commons
Shipra Gupta, Ritin Mohindra,

Manisha Ramola

et al.

Journal of Indian Society of Periodontology, Journal Year: 2024, Volume and Issue: 28(1), P. 113 - 121

Published: Jan. 1, 2024

Abstract: Background: Periodontal disease is associated with immune dysregulation, and cytokines released can add on to the coronavirus 2019 (COVID-19)-associated cytokine storm, further worsening related adverse outcomes. Specific studies investigating levels in COVID-19 patients periodontal are lacking. Examining correlation between these conditions could aid categorizing risk categories, determining referrals, strengthening oral hygiene protocols. The current study sought evaluate saliva of COVID-19-positive without disease. Materials Methods: Twenty-six were subjected examination, collection, assessment through bead-based multiplex assay, using fluorescence-encoded beads flow cytometry (BD FACS LSRFortessa). Eleven assessed (interleukin [IL] 2, 4, 6, 10, 17A, interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-α), chemokine ligand 2 (CCL2/monocyte chemoattractant protein-1), C-X-C motif (CXCL) 8/IL 8, CXCL 9/monokine-induced gamma interferon [MIG]), 10 (chemokine IFN-gamma inducible protein kDa). recruited subjects also compared graphically salivary reported literature for health, COVID-19, alone. Results: Out 26 patients, 17 had Levels all raised both diseases when values alone, or However, there was no statistical difference among IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-gamma, TNF-α, CCL2, 10. MIG found be higher periodontally healthy, ( P = 0.01). Conclusions: might contribute COVID-19-induced potentially amplifying its impact.

Language: Английский

Citations

1
Novel Perspective on the Plasticity of Taste Perception: Is Food- and Exercise-Induced Inflammation Associated with Sweet Taste Sensitivity and Preference? DOI Creative Commons
Isabella Kimmeswenger, Barbara Lieder

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(27), P. 15122 - 15127

Published: June 28, 2024

Obesity-related inflammation has been linked to decreased taste sensitivity and changes in the transcriptome of apparatus. Increased levels pro-inflammatory cytokines can also be found food-associated individuals who consume high amounts long-chain saturated fatty acids sucrose independent body composition or exercise intensively. Previous research suggests a link between food choices. However, interplay food- exercise-induced low-grade inflammation, perception, choices remains unaddressed. Understanding this relationship could provide an unnoticed explanation for interindividual differences perception that influences dietary habits.

Language: Английский

Citations

1
The Mouth as a Site of SARS-CoV-2 Infection DOI Creative Commons
Natalie Atyeo, Paola Pérez, Bruno Fernandes Matuck

et al.

Current Oral Health Reports, Journal Year: 2024, Volume and Issue: 11(2), P. 167 - 176

Published: Feb. 21, 2024

Abstract Purpose of Review During the height coronavirus pandemic, oral cavity was recognized as a critically important site for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The purpose this review is to analyze literature surrounding SARS-CoV-2 entry, replication, and transmission resulting impact on host tissues in cavity. Recent Findings detection viral genetic material saliva allows widespread surveillance testing emphasizes importance through shed saliva. As cohort patients who have recovered from infection grows, several questions remain about long-term impacts tissues, including whether may serve persistent reservoir. Therefore, thorough understanding life cycle diverse warranted. We conclude with broad outlook effects how these relate post-acute sequelae experienced by patients. Summary can enter replicate be spread between individuals via Several manifestations been reported, lingering are an area ongoing investigation.

Language: Английский

Citations

0