Targeting senescent cells to reshape the tumor microenvironment and improve anticancer efficacy

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 101, P. 58 - 73

Published: May 27, 2024

Cancer is daunting pathology with remarkable breadth and scope, spanning genetics, epigenetics, proteomics, metalobomics cell biology. Cellular senescence represents a stress-induced essentially irreversible fate associated aging various age-related diseases, including malignancies. Senescent cells are characterized of morphologic alterations metabolic reprogramming, develop highly active secretome termed as the senescence-associated secretory phenotype (SASP). Since first discovery, has been understood an important barrier to tumor progression, its induction in pre-neoplastic limits carcinogenesis. Paradoxically, senescent arising microenvironment (TME) contribute augmented therapeutic resistance. In this article, we define typical forms commonly observed within TME how functionally remodel their surrounding niche, affect immune responses promote cancer evolution. Furthermore, highlight recently emerging pipelines senotherapies particularly senolytics, which can selectively deplete from affected organs vivo impede progression by restoring securing anticancer efficacies. Together, co-targeting normal but counterparts holds potential achieve increased benefits restrained disease relapse future clinical oncology.

Language: Английский

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Senescent cells: a therapeutic target in correction of aging

Восстановительные биотехнологии, профилактическая, цифровая и предиктивная медицина., Journal Year: 2024, Volume and Issue: 1(3), P. 53 - 53

Published: Jan. 1, 2024

Language: Английский

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B cell senescence promotes age‐related changes in oral microbiota

Aging Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 9, 2024

In recent years, there has been increasing attention towards understanding the relationship between age-related alterations in oral microbiota and age-associated diseases, with reports emphasizing significance of maintaining a balanced for host health. However, precise mechanisms underlying changes remain elusive. We recently reported that cellular senescence ileal germinal center (GC) B cells, triggered by persistent presence commensal bacteria, results diminished IgA production aging subsequent gut microbiota. Consequently, we hypothesize similar phenomenon may occur cavity, potentially contributing to Examination p16-luc mice, wherein expression senescent cell marker p16

Language: Английский

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A morphological post mortem profile in minor salivary glands changes in females

Journal of Molecular Histology, Journal Year: 2024, Volume and Issue: 56(1)

Published: Dec. 6, 2024

Language: Английский

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